Photosensitizer-conjugated polymeric nanoparticles for redox-responsive fluorescence imaging and photodynamic therapy

2013 ◽  
Vol 1 (4) ◽  
pp. 429-431 ◽  
Author(s):  
Hyunjin Kim ◽  
Saehun Mun ◽  
Yongdoo Choi
Keyword(s):  
Photodynamic Therapy ◽  
Fluorescence Imaging ◽  
Polymeric Nanoparticles ◽  
Redox Responsive

A redox-responsive mesoporous silica based nanoplatform for in vitro tumor-specific fluorescence imaging and enhanced photodynamic therapy

2018 ◽  
Vol 6 (1) ◽  
pp. 96-100 ◽  
Author(s):  
Fan Yuan ◽  
Jiang-Lan Li ◽  
Han Cheng ◽  
Xuan Zeng ◽  
Xian-Zheng Zhang
Keyword(s):  
Photodynamic Therapy ◽  
Tumor Microenvironment ◽  
Mesoporous Silica ◽  
Fluorescence Imaging ◽  
Silica Nanoparticle ◽  
Mesoporous Silica Nanoparticle ◽  
Specific Fluorescence ◽  
Redox Responsive ◽  
Multifunctional Peptides

A mesoporous silica nanoparticle-based redox-responsive platform modified with multifunctional peptides was successfully developed for in vitro tumor microenvironment-enhanced photodynamic therapy.

A redox-responsive theranostic agent for target-specific fluorescence imaging and photodynamic therapy of EGFR-overexpressing triple-negative breast cancers

2016 ◽  
Vol 4 (42) ◽  
pp. 6787-6790 ◽  
Author(s):  
Jisu Kim ◽  
Youngjae Won ◽  
Sung-Ho Goh ◽  
Yongdoo Choi
Keyword(s):  
Photodynamic Therapy ◽  
Fluorescence Imaging ◽  
Target Cell ◽  
Triple Negative ◽  
Breast Cancers ◽  
Specific Fluorescence ◽  
Theranostic Agent ◽  
Redox Responsive

A redox-responsive specific theranostic agent for target-cell-specific activatable fluorescence imaging and photodynamic therapy of triple-negative breast cancers.

Ultrasensitive redox-responsive porphyrin-based polymeric nanoparticles for enhanced photodynamic therapy

2019 ◽  
Vol 110 ◽  
pp. 344-354 ◽  
Author(s):  
Yudong Xue ◽  
Jia Tian ◽  
Lei Xu ◽  
Zhiyong Liu ◽  
Yongjia Shen ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Polymeric Nanoparticles ◽  
Redox Responsive

Ubiquinone-BODIPY nanoparticles for tumor redox-responsive fluorescence imaging and photodynamic activity

2021 ◽  
Author(s):  
Byunghee Hwang ◽  
Tae-Il Kim ◽  
Hyunjin Kim ◽  
Sungjin Jeon ◽  
Yongdoo Choi ◽  
...  
Keyword(s):  
Fluorescence Imaging ◽  
Selective Activation ◽  
Turn On ◽  
Intracellular Environment ◽  
Redox Responsive ◽  
Photodynamic Activity

A ubiquinone-BODIPY photosensitizer self-assembles into nanoparticles (PS-Q-NPs) and undergoes selective activation within the highly reductive intracellular environment of tumors, resulting in “turn-on” fluorescence and photosensitizing activities.

Near‐Infrared‐II Nanomaterials for Fluorescence Imaging and Photodynamic Therapy

2021 ◽  
pp. 2002177
Author(s):  
Hongxin Lin ◽  
Zexi Lin ◽  
Konghua Zheng ◽  
Chenlu Wang ◽  
Lisheng Lin ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Fluorescence Imaging ◽  
Near Infrared

Lysosomal targeted NIR photosensitizer for photodynamic therapy and two-photon fluorescent imaging

2021 ◽  
Author(s):  
Ruiyuan Liu ◽  
Yuping Zhou ◽  
Di Zhang ◽  
Genghan He ◽  
Chuang Liu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Fluorescence Imaging ◽  
Near Infrared ◽  
Fluorescent Imaging ◽  
High Fidelity ◽  
Design And Synthesis ◽  
Two Photon ◽  
Two Photon Fluorescence ◽  
Photon Fluorescence

Design and synthesis of near-infrared (NIR) emissive fluorophore for imaging of organelle and photodynamic therapy has received enormous attention. Hence, NIR emissive fluorophore of high-fidelity lysosome targeting, two-photon fluorescence imaging,...

scholarly journals Site-Specific Dual-Labeling of a VHH with a Chelator and a Photosensitizer for Nuclear Imaging and Targeted Photodynamic Therapy of EGFR-Positive Tumors

Cancers ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 428
Author(s):  
Emma Renard ◽  
Estel Collado Camps ◽  
Coline Canovas ◽  
Annemarie Kip ◽  
Martin Gotthardt ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Fluorescence Imaging ◽  
Ex Vivo ◽  
Growth Factor Receptor ◽  
Nuclear Imaging ◽  
A431 Cells ◽  
Site Specific ◽  
Variable Domains ◽  
Diagnostic Probe

Variable domains of heavy chain only antibodies (VHHs) are valuable agents for application in tumor theranostics upon conjugation to both a diagnostic probe and a therapeutic compound. Here, we optimized site-specific conjugation of the chelator DTPA and the photosensitizer IRDye700DX to anti-epidermal growth factor receptor (EGFR) VHH 7D12, for applications in nuclear imaging and photodynamic therapy. 7D12 was site-specifically equipped with bimodal probe DTPA-tetrazine-IRDye700DX using the dichlorotetrazine conjugation platform. Binding, internalization and light-induced toxicity of DTPA-IRDye700DX-7D12 were determined using EGFR-overexpressing A431 cells. Finally, ex vivo biodistribution of DTPA-IRDye700DX-7D12 in A431 tumor-bearing mice was performed, and tumor homing was visualized with SPECT and fluorescence imaging. DTPA-IRDye700DX-7D12 was retrieved with a protein recovery of 43%, and a degree of labeling of 0.56. Spectral properties of the IRDye700DX were retained upon conjugation. 111In-labeled DTPA-IRDye700DX-7D12 bound specifically to A431 cells, and they were effectively killed upon illumination. DTPA-IRDye700DX-7D12 homed to A431 xenografts in vivo, and this could be visualized with both SPECT and fluorescence imaging. In conclusion, the dichlorotetrazine platform offers a feasible method for site-specific dual-labeling of VHH 7D12, retaining binding affinity and therapeutic efficacy. The flexibility of the described approach makes it easy to vary the nature of the probes for other combinations of diagnostic and therapeutic compounds.

Biocompatible fluorenylphthalocyanines for one and two-photon photodynamic therapy and fluorescence imaging

2021 ◽  
pp. 109840
Author(s):  
Seifallah Abid ◽  
Christophe Nguyen ◽  
Morgane Daurat ◽  
Denis Durand ◽  
Bassem Jamoussi ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Fluorescence Imaging ◽  
Two Photon

Current phthalocyanines delivery systems in photodynamic therapy: an updated review

2021 ◽  
Vol 28 ◽  
Author(s):  
Mariana Miretti ◽  
Cesar German Prucca ◽  
Tomas Cristian Tempesti ◽  
Maria Teresa Baumgartner
Keyword(s):  
Photodynamic Therapy ◽  
Polymeric Micelles ◽  
Polymeric Nanoparticles ◽  
Aqueous Media ◽  
Delivery Systems ◽  
Current Status ◽  
Oxygen Species ◽  
Cancer Treatments ◽  
Therapy Efficacy ◽  
Cellular Components

: Photodynamic therapy has emerged as an effective therapeutic alternative to treat oncological, cardiovascular, dermatological, infectious, and ophthalmic diseases. Photodynamic therapy combines the action of a photosensitizer with light in the presence of oxygen to generate reactive oxygen species capable of reacting with cellular components resulting in injury and, consequently, inducing cellular death. Phthalocyanines are considered good photosensitizers, although most of them are lipophilic, difficulting their administration for clinical use. A strategy to overcome the lack of solubility of phthalocyanines in aqueous media is to incorporate them into different delivery systems. The present review aimed to summarize the current status of the main drug delivery systems used for Zn and Al phthalocyanines and their effect in photodynamic therapy, reported in the last five years. Liposomes, polymeric micelles, polymeric nanoparticles, and gold-nanoparticles constituted some of the most used carriers and were discussed in this review. The latest studies reported strongly suggests that the application of nanotechnologies as delivery systems allow an increase in photodynamic therapy efficacy and reduce side-effects associated with the phthalocyanine administration, which represents a promise for cancer treatments.

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