Loading and release of fluorescent oligoarginine peptides into/from pH-responsive anionic supramolecular nanoparticles

2016 ◽  
Vol 4 (22) ◽  
pp. 4025-4032 ◽  
Author(s):  
Laura Graña-Suárez ◽  
Willem Verboom ◽  
Tessa Buckle ◽  
Mark Rood ◽  
Fijs W. B. van Leeuwen ◽  
...  
Keyword(s):  
Ph Sensitive ◽  
Ph Responsive ◽  
Supramolecular Nanoparticles ◽  
Uptake And Release

The uptake and release of fluorescent oligoarginines was studied into/from a pH-sensitive system based on negatively charged fluorescent supramolecular nanoparticles.

scholarly journals Stabilization and Release of Palm Tocotrienol Emulsion Fabricated Using pH-Sensitive Calcium Carbonate

Foods ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 358
Author(s):  
Phui Yee Tan ◽  
Beng Ti Tey ◽  
Eng Seng Chan ◽  
Oi Ming Lai ◽  
Hon Weng Chang ◽  
...  
Keyword(s):  
Calcium Carbonate ◽  
Droplet Size ◽  
Entrapment Efficiency ◽  
Ph Sensitive ◽  
Emulsion System ◽  
Ph Responsive ◽  
Small Droplet ◽  
Homogenization Time ◽  
Oil In Water ◽  
Ph Range

Calcium carbonate (CaCO3) has been utilized as a pH-responsive component in various products. In this present work, palm tocotrienols-rich fraction (TRF) was successfully entrapped in a self-assembled oil-in-water (O/W) emulsion system by using CaCO3 as the stabilizer. The emulsion droplet size, viscosity and tocotrienols entrapment efficiency (EE) were strongly affected by varying the processing (homogenization speed and time) and formulation (CaCO3 and TRF concentrations) parameters. Our findings indicated that the combination of 5000 rpm homogenization speed, 15 min homogenization time, 0.75% CaCO3 concentration and 2% TRF concentration resulted in a high EE of tocotrienols (92.59–99.16%) and small droplet size (18.83 ± 1.36 µm). The resulting emulsion system readily released the entrapped tocotrienols across the pH range tested (pH 1–9); with relatively the highest release observed at pH 3. The current study presents a potential pH-sensitive emulsion system for the entrapment and delivery of palm tocotrienols.

Construction of a pH-sensitive self-assembly in aqueous solutions based on a dansyl-modified β-cyclodextrin

Soft Matter ◽  
2021 ◽  
Author(s):  
Bing Jiang ◽  
Yu Liu ◽  
Linlin Zhao ◽  
Li Zhao ◽  
Ce Wang ◽  
...  
Keyword(s):  
Aqueous Solutions ◽  
Self Assembly ◽  
Ph Sensitive ◽  
Ph Responsive ◽  
Ph Range

Here we present a pH-responsive self-assembly based on a β-cyclodextrin (β-CD) derivative bearing a dansyl terminus (βCD-C6-Dns). Vesicular structures were formed over the entire studied pH range (8.5-0.7); however, the...

scholarly journals Mitochondrial Targeting and pH-Responsive Nanogels for Co-Delivery of Lonidamine and Paclitaxel to Conquer Drug Resistance

2021 ◽  
Vol 9 ◽  
Author(s):  
Enping Chen ◽  
Ting Wang ◽  
Junmei Zhang ◽  
Xiang Zhou ◽  
Yafan Niu ◽  
...  
Keyword(s):  
Drug Loading ◽  
Ph Sensitive ◽  
Combination Regimen ◽  
Drug Efflux ◽  
Drug Resistant ◽  
Oxygen Species ◽  
Chemotherapeutic Drug ◽  
Mitochondrial Targeting ◽  
Ph Responsive ◽  
Mcf 7

Multidrug resistance (MDR) is one of the leading causes of the failure of cancer chemotherapy and mainly attributed to the overexpression of drug efflux transporters in cancer cells, which is dependent on adenosine triphosphate (ATP). To overcome this phenomenon, herein, a mitochondrial-directed pH-sensitive polyvinyl alcohol (PVA) nanogel incorporating the hexokinase inhibitor lonidamine (LND) and the chemotherapeutic drug paclitaxel (PTX) was developed to restore the activity of PTX and synergistically treat drug-resistant tumors. The introduction of 2-dimethylaminoethanethiol (DMA) moiety into the nanogels not only promoted the drug loading capacity but also enabled the lysosomal escape of the nanogels. The subsequent mitochondrial targeting facilitated the accumulation and acid-triggered payload release in the mitochondria. The released LND can destroy the mitochondria by exhausting the mitochondrial membrane potential (MMP), generating reactive oxygen species (ROS) and restraining the energy supply, resulting in apoptosis and susceptibility of the MCF-7/MDR cells to PTX. Hence, the nanogel-enabled combination regimen of LND and PTX showed a boosted anti-tumor efficacy in MCF-7/MDR cells. These mitochondrial-directed pH-sensitive PVA nanogels incorporating both PTX and LND represent a new nanoplatform for MDR reversal and enhanced therapeutic efficacy.

scholarly journals One-pot synthesis of biodegradable polydopamine-doped mesoporous silica nanocomposites (PMSNs) as pH-sensitive targeting drug nanocarriers for synergistic chemo-photothermal therapy

RSC Advances ◽  
2018 ◽  
Vol 8 (65) ◽  
pp. 37433-37440 ◽  
Author(s):  
Huicong Zhang ◽  
Xuandong Wang ◽  
Peiyuan Wang ◽  
Rong Liu ◽  
Xuemei Hou ◽  
...  
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Photothermal Therapy ◽  
Ph Sensitive ◽  
Ph Responsive ◽  
One Pot ◽  
Silica Nanocomposites ◽  
One Pot Synthesis ◽  
Drug Nanocarriers

Polydopamine-doped mesoporous silica nanocomposites (PMSNs) were controllably synthesized by a one-pot approach. They were demonstrated to be good biodegradability, pH-responsive drug release and targeting synergistic chemo-photothermal therapy.

Functionalized O-carboxymethyl-chitosan/polyethylenimine based novel dual pH-responsive nanocarriers for controlled co-delivery of DOX and genes

2015 ◽  
Vol 6 (17) ◽  
pp. 3324-3335 ◽  
Author(s):  
Mingfang Wang ◽  
Tingxian Liu ◽  
Leiqiang Han ◽  
Wenwen Gao ◽  
Shaomei Yang ◽  
...  
Keyword(s):  
Carboxymethyl Chitosan ◽  
Ph Sensitive ◽  
Ph Responsive ◽  
Outermost Layer

Dual pH-sensitive CDPD sequentially dissociates the outermost layer, CPN, and shows pH-triggered programmable release of DOX and genes.

scholarly journals Novel monomers in radical ring-opening polymerisation for biodegradable and pH responsive nanoparticles

2019 ◽  
Vol 10 (39) ◽  
pp. 5285-5288 ◽  
Author(s):  
Jenny Folini ◽  
Chao-Hung Huang ◽  
James C. Anderson ◽  
Wolfgang P. Meier ◽  
Jens Gaitzsch
Keyword(s):  
Ring Opening ◽  
Ph Sensitive ◽  
Ph Responsive ◽  
Radical Ring ◽  
Cyclic Ketene Acetals ◽  
Ketene Acetals

We report the first amine-bearing cyclic ketene acetals (CKAs) for radical ring-opening polymerisation (RROP). The resulting polyesters and their corresponding nanoparticles were biodegradable and showed the desired pH sensitive behaviour.

scholarly journals ENZYMATICALLY SYNTHESIZED pH-RESPONSIVE IPN FOR IN-SITU RELEASE OF PANTOPRAZOLE SODIUM

2019 ◽  
pp. 98-103
Author(s):  
Saruchi Sharma ◽  
VANEET KUMAR
Keyword(s):  
Drug Release ◽  
Polymer Network ◽  
Lateral Diffusion ◽  
Ph Sensitive ◽  
Interpenetrating Polymer Network ◽  
Release Behavior ◽  
Ph Responsive ◽  
Gum Tragacanth ◽  
Swelling Capacity

Objective: This study involves the synthesis of Gum tragacanth (gt) based interpenetrating polymer network (ipn) and its utilization for sustained release of anti-ulcerative drug i.e. pantoprazole sodium. Methods: IPN was synthesized from Gum tragacanth, polyacrylic acid (gt-cl-paa) hydrogel. gt-cl-paa was kept in distilled water. Further, acryamide (aam) and methylmethacrylate (mma) was added and then kept for overnight. Later on, lipase and glutaraldehyde were added. Homopolymers and the unreacted monomers were removed using acetone. Synthesized IPN was dried at 50 °C for further study. Synthesized ipn was swelled in water and the drug was added to it. The drug was entrapped in the pores of the synthesized ipn and then drug release behavior was studied using uv-vis spectrophotometer. Results: Gt, paa and mma based crosslinked IPN were synthesized using lipase-glutaraldehyde as initiator-crosslinker system. The synthesized IPN was pH sensitive and possessed the desired swelling capacity required for the controlled and systematic liberation of pantoprazole sodium at 37 °C. The kinetic of drug release was studied and found that lateral diffusion (DL) of drug was higher as compared to the initial diffusion (DI). The prepared IPN can be used as prospective carrier for prolonged drug delivery. Conclusion: A novel pH sensitive and colon targeted IPN was synthesized. It acts as an effective device for the controlled release of drug pantoprazole sodium.

Zwitterionic supramolecular nanoparticles: self-assembly and responsive properties

Nanoscale ◽  
2015 ◽  
Vol 7 (17) ◽  
pp. 7915-7919 ◽  
Author(s):  
Carmen Stoffelen ◽  
Jurriaan Huskens
Keyword(s):  
Self Assembly ◽  
Ph Responsive ◽  
Supramolecular Nanoparticles

Zwitterionic supramolecular nanoparticles (ZSNPs) show photo- and pH-responsive properties and are stable in high-BSA solutions.

Graphene Oxide Based Nanocarrier Combined with a pH-Sensitive Tracer: A Vehicle for Concurrent pH Sensing and pH-Responsive Oligonucleotide Delivery

2015 ◽  
Vol 7 (21) ◽  
pp. 11467-11475 ◽  
Author(s):  
Chia-Jung Hsieh ◽  
Yu-Cheng Chen ◽  
Pei-Ying Hsieh ◽  
Shi-Rong Liu ◽  
Shu-Pao Wu ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Ph Sensitive ◽  
Ph Sensing ◽  
Ph Responsive ◽  
Oligonucleotide Delivery

Glutathione functionalized mesoporous organosilica conjugate for drug delivery

RSC Advances ◽  
2016 ◽  
Vol 6 (61) ◽  
pp. 56287-56293 ◽  
Author(s):  
Lin-Lin Hu ◽  
Dan-Dan Zhang ◽  
Yang Zhang ◽  
Yang Shu ◽  
Xu-Wei Chen ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Polyacrylic Acid ◽  
Ph Sensitive ◽  
Ph Responsive ◽  
Mesoporous Organosilica

We developed a novel pH-responsive drug delivery system based on permeation-enhancing glutathione (GSH) and pH sensitive polyacrylic acid (PAA) grafted mesoporous organosilica nanocarriers (MONs).

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