Graphene Oxide Based Nanocarrier Combined with a pH-Sensitive Tracer: A Vehicle for Concurrent pH Sensing and pH-Responsive Oligonucleotide Delivery

2015 ◽  
Vol 7 (21) ◽  
pp. 11467-11475 ◽  
Author(s):  
Chia-Jung Hsieh ◽  
Yu-Cheng Chen ◽  
Pei-Ying Hsieh ◽  
Shi-Rong Liu ◽  
Shu-Pao Wu ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Ph Sensitive ◽  
Ph Sensing ◽  
Ph Responsive ◽  
Oligonucleotide Delivery

scholarly journals Stabilization and Release of Palm Tocotrienol Emulsion Fabricated Using pH-Sensitive Calcium Carbonate

Foods ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 358
Author(s):  
Phui Yee Tan ◽  
Beng Ti Tey ◽  
Eng Seng Chan ◽  
Oi Ming Lai ◽  
Hon Weng Chang ◽  
...  
Keyword(s):  
Calcium Carbonate ◽  
Droplet Size ◽  
Entrapment Efficiency ◽  
Ph Sensitive ◽  
Emulsion System ◽  
Ph Responsive ◽  
Small Droplet ◽  
Homogenization Time ◽  
Oil In Water ◽  
Ph Range

Calcium carbonate (CaCO3) has been utilized as a pH-responsive component in various products. In this present work, palm tocotrienols-rich fraction (TRF) was successfully entrapped in a self-assembled oil-in-water (O/W) emulsion system by using CaCO3 as the stabilizer. The emulsion droplet size, viscosity and tocotrienols entrapment efficiency (EE) were strongly affected by varying the processing (homogenization speed and time) and formulation (CaCO3 and TRF concentrations) parameters. Our findings indicated that the combination of 5000 rpm homogenization speed, 15 min homogenization time, 0.75% CaCO3 concentration and 2% TRF concentration resulted in a high EE of tocotrienols (92.59–99.16%) and small droplet size (18.83 ± 1.36 µm). The resulting emulsion system readily released the entrapped tocotrienols across the pH range tested (pH 1–9); with relatively the highest release observed at pH 3. The current study presents a potential pH-sensitive emulsion system for the entrapment and delivery of palm tocotrienols.

Construction of a pH-sensitive self-assembly in aqueous solutions based on a dansyl-modified β-cyclodextrin

Soft Matter ◽  
2021 ◽  
Author(s):  
Bing Jiang ◽  
Yu Liu ◽  
Linlin Zhao ◽  
Li Zhao ◽  
Ce Wang ◽  
...  
Keyword(s):  
Aqueous Solutions ◽  
Self Assembly ◽  
Ph Sensitive ◽  
Ph Responsive ◽  
Ph Range

Here we present a pH-responsive self-assembly based on a β-cyclodextrin (β-CD) derivative bearing a dansyl terminus (βCD-C6-Dns). Vesicular structures were formed over the entire studied pH range (8.5-0.7); however, the...

pH-Sensitive graphene oxide/sodium alginate/polyacrylamide nanocomposite semi-IPN hydrogel with improved mechanical strength

RSC Advances ◽  
2015 ◽  
Vol 5 (108) ◽  
pp. 89083-89091 ◽  
Author(s):  
Huijuan Zhang ◽  
Xianjuan Pang ◽  
Yuan Qi
Keyword(s):  
Graphene Oxide ◽  
Mechanical Strength ◽  
Sodium Alginate ◽  
Ph Sensitive ◽  
Swelling Behavior ◽  
Ph Dependent

A pH-sensitive and mechanically strong graphene oxide/sodium alginate/polyacrylamide nanocomposite semi-IPN hydrogel was designed and prepared. The composite semi-IPN hydrogel showed superior mechanical strength and pH-dependent swelling behavior.

scholarly journals Mitochondrial Targeting and pH-Responsive Nanogels for Co-Delivery of Lonidamine and Paclitaxel to Conquer Drug Resistance

2021 ◽  
Vol 9 ◽  
Author(s):  
Enping Chen ◽  
Ting Wang ◽  
Junmei Zhang ◽  
Xiang Zhou ◽  
Yafan Niu ◽  
...  
Keyword(s):  
Drug Loading ◽  
Ph Sensitive ◽  
Combination Regimen ◽  
Drug Efflux ◽  
Drug Resistant ◽  
Oxygen Species ◽  
Chemotherapeutic Drug ◽  
Mitochondrial Targeting ◽  
Ph Responsive ◽  
Mcf 7

Multidrug resistance (MDR) is one of the leading causes of the failure of cancer chemotherapy and mainly attributed to the overexpression of drug efflux transporters in cancer cells, which is dependent on adenosine triphosphate (ATP). To overcome this phenomenon, herein, a mitochondrial-directed pH-sensitive polyvinyl alcohol (PVA) nanogel incorporating the hexokinase inhibitor lonidamine (LND) and the chemotherapeutic drug paclitaxel (PTX) was developed to restore the activity of PTX and synergistically treat drug-resistant tumors. The introduction of 2-dimethylaminoethanethiol (DMA) moiety into the nanogels not only promoted the drug loading capacity but also enabled the lysosomal escape of the nanogels. The subsequent mitochondrial targeting facilitated the accumulation and acid-triggered payload release in the mitochondria. The released LND can destroy the mitochondria by exhausting the mitochondrial membrane potential (MMP), generating reactive oxygen species (ROS) and restraining the energy supply, resulting in apoptosis and susceptibility of the MCF-7/MDR cells to PTX. Hence, the nanogel-enabled combination regimen of LND and PTX showed a boosted anti-tumor efficacy in MCF-7/MDR cells. These mitochondrial-directed pH-sensitive PVA nanogels incorporating both PTX and LND represent a new nanoplatform for MDR reversal and enhanced therapeutic efficacy.

pH-responsive, DNA-directed reversible assembly of graphene oxide

2011 ◽  
Vol 7 (9) ◽  
pp. 2681 ◽  
Author(s):  
Konggang Qu ◽  
Jinsong Ren ◽  
Xiaogang Qu
Keyword(s):  
Graphene Oxide ◽  
Ph Responsive

scholarly journals Carboxymethyl cellulose-grafted graphene oxide for efficient antitumor drug delivery

2018 ◽  
Vol 7 (4) ◽  
pp. 291-301 ◽  
Author(s):  
Zepeng Jiao ◽  
Bin Zhang ◽  
Chunya Li ◽  
Weicong Kuang ◽  
Jingxian Zhang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Drug Delivery System ◽  
Delivery System ◽  
Carboxymethyl Cellulose ◽  
Drug Carrier ◽  
Controlled Drug Release ◽  
Ph Sensitive ◽  
Tumor Growth Inhibition

Abstract A drug delivery system based on carboxymethyl cellulose-grafted graphene oxide loaded by methotrexate (MTX/CMC-GO) with pH-sensitive and controlled drug-release properties was developed in this work. CMC was grafted on graphene oxide by ethylenediamine through hydrothermal treatment. CMC serves as a pH-sensitive trigger, while CMC-GO serves as a drug-carrying vehicle due to the curved layer and large plain surface. Different amounts of drugs could be loaded into CMC-GO nanocarriers by control of the original amount of drug/carrier ratios. Additionally, low cytotoxicity against NIH-3T3 cells and low in vivo toxicity was observed. In vivo tumor growth inhibition assays showed that MTX/CMC-GO demonstrated superior antitumor activity than free MTX against HT-29 cells. Moreover, prolonged survival time of mice was observed after MTX/CMC-GO administration. The MTX/CMC-GO drug delivery system has a great potential in colon cancer therapy.

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