scholarly journals Laccase-catalyzed green synthesis and cytotoxic activity of novel pyrimidobenzothiazoles and catechol thioethers

RSC Advances ◽  
2017 ◽  
Vol 7 (28) ◽  
pp. 17427-17441 ◽  
Author(s):  
H. T. Abdel-Mohsen ◽  
J. Conrad ◽  
K. Harms ◽  
D. Nohr ◽  
U. Beifuss
Keyword(s):  
Green Synthesis ◽  
Cytotoxic Activity ◽  
Cell Line ◽  
Hepg2 Cell ◽  
Hepg2 Cell Line ◽  
Line P ◽  
Antiproliferative Activities

Laccase-catalyzed green reaction between catechols and 2-thioxopyrimidin-4-ones delivers novel pyrimidobenzothiazoles and catechol thioethers with antiproliferative activities against HepG2 cell line.

Preparation of stabilized silver nanoparticles and study of their antimicrobial and cytotoxic activity on the human hepatoma HepG2 cell line

2019 ◽  
Vol 14 (5-6) ◽  
pp. 273-279
Author(s):  
M. A. Ananyan ◽  
A. G. Demchenko ◽  
V. S. Sadykova ◽  
A. V. Lyundup ◽  
T. I. Gromovykh ◽  
...  
Keyword(s):  
Silver Nanoparticles ◽  
Cytotoxic Activity ◽  
Cell Line ◽  
Hepg2 Cell ◽  
Human Hepatoma ◽  
Hepg2 Cell Line ◽  
Hepatoma Hepg2

X-ray structure of two Schiff bases: TURN-ON sensing of Fe3+ and Al3+ in the HepG2 cell line

2020 ◽  
Vol 12 (45) ◽  
pp. 5485-5495
Author(s):  
Sunanda Dey ◽  
Suvendu Maity ◽  
Rakesh Purkait ◽  
Kunal Pal ◽  
Prasanta Ghosh ◽  
...  
Keyword(s):  
Single Crystal ◽  
Cell Line ◽  
Schiff Bases ◽  
Hepg2 Cell ◽  
Aqueous Media ◽  
Hepg2 Cell Line ◽  
X Ray ◽  
Turn On ◽  
Line P

Two single-crystal X-ray characterized Schiff bases (HL′ and H2L′′) are prepared to sense Fe3+ and Al3+ ions, respectively, in aqueous media.

scholarly journals Targeting Receptor Tyrosine Kinase VEGFR-2 in Hepatocellular Cancer: Rational Design, Synthesis and Biological Evaluation of 1,2-Disubstituted Benzimidazoles

Molecules ◽  
2020 ◽  
Vol 25 (4) ◽  
pp. 770 ◽  
Author(s):  
Heba T. Abdel-Mohsen ◽  
Mona A. Abdullaziz ◽  
Ahmed M. El Kerdawy ◽  
Fatma A. F. Ragab ◽  
Keith J. Flanagan ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cytotoxic Activity ◽  
Cell Line ◽  
Hepg2 Cell ◽  
Inhibitory Activity ◽  
Rational Design ◽  
Hydrophobic Interactions ◽  
Biological Evaluation ◽  
Benzimidazole Derivatives ◽  
Hepg2 Cell Line

In this study, a novel series of 1,2-disubstituted benzo[d]imidazoles was rationally designed as VEGFR-2 inhibitors targeting hepatocellular carcinoma. Our design strategy is two-fold; it aimed first at studying the effect of replacing the 5-methylfuryl moiety of the well-known antiangiogenic 2-furylbenzimidazoles with an isopropyl moiety on the VEGFR-2 inhibitory activity and the cytotoxic activity. Our second objective was to further optimize the structures of the benzimidazole derivatives through elongation of the side chains at their one-position for the design of more potent type II-like VEGFR-2 inhibitors. The designed 1,2-disubstituted benzimidazoles demonstrated potent cytotoxic activity against the HepG2 cell line, reaching IC50 = 1.98 μM in comparison to sorafenib (IC50 = 10.99 μM). In addition, the synthesized compounds revealed promising VEGFR-2 inhibitory activity in the HepG2 cell line, e.g., compounds 17a and 6 showed 82% and 80% inhibition, respectively, in comparison to sorafenib (% inhibition = 92%). Studying the effect of 17a on the HepG2 cell cycle demonstrated that 17a arrested the cell cycle at the G2/M phase and induced a dose-dependent apoptotic effect. Molecular docking studies of the synthesized 1,2-disubstituted benzimidazoles in the VEGFR-2 active site displayed their ability to accomplish the essential hydrogen bonding and hydrophobic interactions for optimum inhibitory activity.

scholarly journals Assessment of Toxicity of Selenium Nanoparticle Varnish Using HepG2 Cell Lines: In vitro Study

2020 ◽  
pp. 33-39
Author(s):  
M. Indumathy ◽  
S. S. Raj ◽  
I. Meignana Arumugham ◽  
R. Pradeep Kumar
Keyword(s):  
Antimicrobial Agent ◽  
Cytotoxic Activity ◽  
Cell Line ◽  
Hepg2 Cell ◽  
In Vitro Study ◽  
Essential Trace Element ◽  
Hepg2 Cell Line ◽  
Selenium Nanoparticle ◽  
Hepg2 Cell Lines

Selenium, an essential trace element, plays an important role in mammalian biology. Selenium nanoparticles (SeNPs) have gained significant importance because of its bioavailability, least toxicity, its interaction with proteins and its biocompatibility. The objective of the present study is to assess the cytotoxicity of SeNPs by testing on HepG2 cell line. The cytotoxicity of nanoparticles on HepG2 cell line was studied by MTT assay. Cytotoxicity was determined using Graph pad prim5 software. The SeNPs showed cytotoxic activity against HepG2 cell line with 77%, 63% and 33.7% of cell viability at 2μg/ ml, 4μg/ml and 30μg/ml concentration respectively. Biogenic SeNPs exhibited cytotoxic activity against the HepG2 cell line and hence warrants further research regarding its biosafety and potential oral antimicrobial agent.

scholarly journals Metformin attenuates hypoxia‑induced resistance to cisplatin in the HepG2 cell line

2018 ◽  
Author(s):  
Hiromasa Fujita ◽  
Katsumi Hirose ◽  
Mariko Sato ◽  
Ichitaro Fujioka ◽  
Tamaki Fujita ◽  
...  
Keyword(s):  
Cell Line ◽  
Hepg2 Cell ◽  
Induced Resistance ◽  
Hepg2 Cell Line
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