scholarly journals Metformin attenuates hypoxia‑induced resistance to cisplatin in the HepG2 cell line

2018 ◽  
Author(s):  
Hiromasa Fujita ◽  
Katsumi Hirose ◽  
Mariko Sato ◽  
Ichitaro Fujioka ◽  
Tamaki Fujita ◽  
...  
Keyword(s):  
Cell Line ◽  
Hepg2 Cell ◽  
Induced Resistance ◽  
Hepg2 Cell Line

Preliminary screening of some traditional Zulu medicinal plants for antineoplastic activities versus the HepG2 cell line

2000 ◽  
Vol 14 (7) ◽  
pp. 534-537 ◽  
Author(s):  
A. R. Opoku ◽  
M. Geheeb-Keller ◽  
J. Lin ◽  
S. E. Terblanche ◽  
A. Hutchings ◽  
...  
Keyword(s):  
Medicinal Plants ◽  
Cell Line ◽  
Hepg2 Cell ◽  
Hepg2 Cell Line ◽  
Preliminary Screening

scholarly journals Isolation and identification of heterogenic subpopulation from the HepG2 cell line by Rhodamine123 extrusion assay

2008 ◽  
Vol 16 (9) ◽  
pp. 941
Author(s):  
Nian-Song Qian ◽  
Ren Li ◽  
Heng-Chao Yu ◽  
Yun-Xin Cao ◽  
Fu-Qin Zhang ◽  
...  
Keyword(s):  
Cell Line ◽  
Hepg2 Cell ◽  
Hepg2 Cell Line ◽  
Isolation And Identification

scholarly journals Atomic force microscopy correlates antimetastatic potentials of HepG2 cell line with its redox/energy status: effects of curcumin and Khaya senegalensis

2017 ◽  
Vol 15 (3) ◽  
pp. 214-230 ◽  
Author(s):  
Jeremiah Olorunjuwon Olugbami ◽  
Robert Damoiseaux ◽  
Bryan France ◽  
Michael A. Gbadegesin ◽  
Adam Z. Stieg ◽  
...  
Keyword(s):  
Atomic Force Microscopy ◽  
Cell Line ◽  
Hepg2 Cell ◽  
Hepg2 Cell Line ◽  
Energy Status ◽  
Force Microscopy ◽  
Atomic Force ◽  
Khaya Senegalensis

Effects of imidacloprid on viability and increase of reactive oxygen and nitrogen species in HepG2 cell line

2021 ◽  
pp. 1-33
Author(s):  
Anilda Rufino de Jesus Santos Guimarães ◽  
Paulo Francisco Veiga Bizerra ◽  
Camila Araújo Miranda ◽  
Fábio Erminio Mingatto
Keyword(s):  
Cell Line ◽  
Hepg2 Cell ◽  
Reactive Oxygen ◽  
Nitrogen Species ◽  
Hepg2 Cell Line

Toxicity and metabolism of deoxynivalenol in human hepatoma (HepG2) cell line

2018 ◽  
Vol 295 ◽  
pp. S146-S147
Author(s):  
L. Radko ◽  
A. Tkaczyk ◽  
P. Jedziniak ◽  
S. Stypuła-Trębas ◽  
A. Posyniak
Keyword(s):  
Cell Line ◽  
Hepg2 Cell ◽  
Human Hepatoma ◽  
Hepg2 Cell Line ◽  
Hepatoma Hepg2

scholarly journals Synthesis and Antiplasmodial Evaluation of 4-Carboxamido- and 4-Alkoxy-2-Trichloromethyl Quinazolines

Molecules ◽  
2020 ◽  
Vol 25 (17) ◽  
pp. 3929
Author(s):  
Dyhia Amrane ◽  
Armand Gellis ◽  
Sébastien Hutter ◽  
Marion Prieri ◽  
Pierre Verhaeghe ◽  
...  
Keyword(s):  
Cell Line ◽  
Hepg2 Cell ◽  
Alkoxy Group ◽  
Hepg2 Cell Line ◽  
Ccl3 Group ◽  
Falciparum Strain ◽  
Structure Activity ◽  
Trichloromethyl Group ◽  
Sar Study

From three previously identified antiplasmodial hit compounds (A–C) and inactive series (D), all based on a 2-trichloromethylquinazoline scaffold, we conducted a structure-activity relationship (SAR) study at position four of the quinazoline ring by synthesizing 42 novel derivatives bearing either a carboxamido- or an alkoxy-group, to identify antiplasmodial compounds and to enrich the knowledge about the 2-trichloromethylquinazoline antiplasmodial pharmacophore. All compounds were evaluated in vitro for their cytotoxicity towards the HepG2 cell line and their activity against the multiresistant K1 P. falciparum strain, using doxorubicin, chloroquine and doxycycline as reference drugs. Four hit-compounds (EC50 K1 P. falciparum ≤ 2 µM and SI ≥ 20) were identified among 4-carboxamido derivatives (2, 9, 16, and 24) and two among 4-alkoxy derivatives (41 and 44). Regarding the two most potent molecules (16 and 41), five derivatives without a 2-CCl3 group were prepared, evaluated, and appeared totally inactive (EC50 > 50 µM), showing that the 2-trichloromethyl group was mandatory for the antiplasmodial activity.

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