Multifunctional poly(glycolic acid-co-propylene fumarate) electrospun fibers reinforced with graphene oxide and hydroxyapatite nanorods

2017 ◽  
Vol 5 (22) ◽  
pp. 4084-4096 ◽  
Author(s):  
Ana M. Díez-Pascual ◽  
Angel L. Díez-Vicente
Keyword(s):  
Tissue Engineering ◽  
Graphene Oxide ◽  
Soft Tissue ◽  
Bactericidal Activity ◽  
Glycolic Acid ◽  
Electrospun Fibers ◽  
Hybrid Nanocomposite ◽  
High Stiffness ◽  
Nanocomposite Fibers ◽  
Soft Tissue Engineering

Biocompatible and biodegradable PGA-co-PPF/HA/GO hybrid nanocomposite fibers with high stiffness and good bactericidal activity have been developed for soft tissue engineering.

scholarly journals Design of graphene oxide/gelatin electrospun nanocomposite fibers for tissue engineering applications

RSC Advances ◽  
2016 ◽  
Vol 6 (110) ◽  
pp. 109150-109156 ◽  
Author(s):  
Sakthivel Nagarajan ◽  
Céline Pochat-Bohatier ◽  
Catherine Teyssier ◽  
Sébastien Balme ◽  
Philippe Miele ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Tissue Engineering ◽  
Graphene Oxide ◽  
Cell Viability ◽  
Significant Influence ◽  
Cell Attachment ◽  
Electrospun Fibers ◽  
Engineering Applications ◽  
Nanocomposite Fibers

2D graphene oxide (GO) is used to enhance the mechanical properties of gelatin electrospun fibers. The GO does not show any significant influence on cell viability and cell attachment even though the expression of osteoblast gene is affected.

scholarly journals In vitroevaluation of poly (lactic-co-glycolic acid)/polyisoprene fibers for soft tissue engineering

2016 ◽  
Vol 105 (8) ◽  
pp. 2581-2591 ◽  
Author(s):  
Douglas R. Marques ◽  
Luís A. L. dos Santos ◽  
Marie A. O'Brien ◽  
Sarah H. Cartmell ◽  
Julie E. Gough
Keyword(s):  
Tissue Engineering ◽  
Soft Tissue ◽  
Glycolic Acid ◽  
Soft Tissue Engineering

Biodegradable polyurethane/graphene oxide scaffolds for soft tissue engineering: in vivo behavior assessment

2019 ◽  
Vol 69 (17) ◽  
pp. 1101-1111 ◽  
Author(s):  
Aleksandra Ivanoska-Dacikj ◽  
Gordana Bogoeva-Gaceva ◽  
Andres Krumme ◽  
Elvira Tarasova ◽  
Chiara Scalera ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Graphene Oxide ◽  
Soft Tissue ◽  
Behavior Assessment ◽  
Biodegradable Polyurethane ◽  
Soft Tissue Engineering

scholarly journals Enzyme-Crosslinked Electrospun Fibrous Gelatin Hydrogel for Potential Soft Tissue Engineering

Polymers ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 1977
Author(s):  
Kexin Nie ◽  
Shanshan Han ◽  
Jianmin Yang ◽  
Qingqing Sun ◽  
Xiaofeng Wang ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Soft Tissue ◽  
Tissue Regeneration ◽  
Water Solution ◽  
Cellular Adhesion ◽  
Fibrous Structure ◽  
Electrospun Fibers ◽  
Hydrogel Scaffolds ◽  
Cell Functions ◽  
Soft Tissue Engineering

Soft tissue engineering has been seeking ways to mimic the natural extracellular microenvironment that allows cells to migrate and proliferate to regenerate new tissue. Therefore, the reconstruction of soft tissue requires a scaffold possessing the extracellular matrix (ECM)-mimicking fibrous structure and elastic property, which affect the cell functions and tissue regeneration. Herein, an effective method for fabricating nanofibrous hydrogel for soft tissue engineering is demonstrated using gelatin–hydroxyphenylpropionic acid (Gel–HPA) by electrospinning and enzymatic crosslinking. Gel–HPA fibrous hydrogel was prepared by crosslinking the electrospun fibers in ethanol-water solution with an optimized concentration of horseradish peroxidase (HRP) and H2O2. The prepared fibrous hydrogel held the soft and elastic mechanical property of hydrogels and the three-dimensional (3D) fibrous structure of electrospun fibers. It was proven that the hydrogel scaffolds were biocompatible, improving the cellular adhesion, spreading, and proliferation. Moreover, the fibrous hydrogel showed rapid biodegradability and promoted angiogenesis in vivo. Overall, this study represents a novel biomimetic approach to generate Gel–HPA fibrous hydrogel scaffolds which have excellent potential in soft tissue regeneration applications.

scholarly journals Electrospun PCL/PGS Composite Fibers Incorporating Bioactive Glass Particles for Soft Tissue Engineering Applications

Nanomaterials ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. 978 ◽  
Author(s):  
Marina Luginina ◽  
Katharina Schuhladen ◽  
Roberto Orrú ◽  
Giacomo Cao ◽  
Aldo R. Boccaccini ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Soft Tissue ◽  
Bioactive Glass ◽  
Fiber Diameter ◽  
Diameter Distribution ◽  
Electrospun Fibers ◽  
Average Fiber Diameter ◽  
Composite Fibers ◽  
Engineering Applications ◽  
Soft Tissue Engineering

Poly(glycerol-sebacate) (PGS) and poly(epsilon caprolactone) (PCL) have been widely investigated for biomedical applications in combination with the electrospinning process. Among others, one advantage of this blend is its suitability to be processed with benign solvents for electrospinning. In this work, the suitability of PGS/PCL polymers for the fabrication of composite fibers incorporating bioactive glass (BG) particles was investigated. Composite electrospun fibers containing silicate or borosilicate glass particles (13-93 and 13-93BS, respectively) were obtained and characterized. Neat PCL and PCL composite electrospun fibers were used as control to investigate the possible effect of the presence of PGS and the influence of the bioactive glass particles. In fact, with the addition of PGS an increase in the average fiber diameter was observed, while in all the composite fibers, the presence of BG particles induced an increase in the fiber diameter distribution, without changing significantly the average fiber diameter. Results confirmed that the blended fibers are hydrophilic, while the addition of BG particles does not affect fiber wettability. Degradation test and acellular bioactivity test highlight the release of the BG particles from all composite fibers, relevant for all applications related to therapeutic ion release, i.e., wound healing. Because of weak interface between the incorporated BG particles and the polymeric fibers, mechanical properties were not improved in the composite fibers. Promising results were obtained from preliminary biological tests for potential use of the developed mats for soft tissue engineering applications.

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