A new trick (hydroxyl radical generation) of an old vitamin (B2) for near-infrared-triggered photodynamic therapy

RSC Advances ◽  
2016 ◽  
Vol 6 (104) ◽  
pp. 102647-102656 ◽  
Author(s):  
Fang Xu ◽  
Jin Li ◽  
Ting-ting Zhu ◽  
Sheng-Song Yu ◽  
Chong Zuo ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Hydroxyl Radical ◽  
Near Infrared ◽  
Vitamin B ◽  
Vitamin B2 ◽  
Nir Light ◽  
Radical Generation

A new NIR-light-triggered PDT method has been developed using an old vitamin (vitamin B2) integrated with the upconversion nanotechnology.

Biodegradable Nano-photosensitizer with Photoactivatable Singlet Oxygen Generation for Synergistic Phototherapy

2021 ◽  
Author(s):  
Jiaxin Shen ◽  
Dandan Chen ◽  
Ye Liu ◽  
Guoyang Gao ◽  
Zhihe Liu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Therapy ◽  
Singlet Oxygen ◽  
Near Infrared ◽  
Promising Method ◽  
Normal Cells ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation ◽  
Nir Light

Photodynamic therapy (PDT) is a promising method for cancer therapy and also may initiate unexpected damages to normal cells and tissues. Herein, we developed a near-infrared (NIR) light-activatable nanophotosensitizer, which...

Ultralow-intensity near infrared light synchronously activated collaborative chemo/photothermal/photodynamic therapy

2020 ◽  
Vol 8 (2) ◽  
pp. 607-618 ◽  
Author(s):  
Renlu Han ◽  
Keqi Tang ◽  
Yafei Hou ◽  
Jiancheng Yu ◽  
Chenlu Wang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Near Infrared ◽  
Infrared Light ◽  
Near Infrared Light ◽  
Nir Light

An ultralow-intensity 808 nm NIR light with 0.25 W cm−2 synchronously activated collaborative Chemo/Photothermal/Photodynamic therapy system was developed.

scholarly journals Single-atom replacement as a general approach towards visible-light/near-infrared heavy-atom-free photosensitizers for photodynamic therapy

2020 ◽  
Vol 11 (26) ◽  
pp. 6701-6708 ◽  
Author(s):  
Juan Tang ◽  
Lushun Wang ◽  
Axel Loredo ◽  
Carson Cole ◽  
Han Xiao
Keyword(s):  
Photodynamic Therapy ◽  
Oxygen Atom ◽  
Visible Light ◽  
Near Infrared ◽  
Heavy Atom ◽  
Single Atom ◽  
General Strategy ◽  
Nir Light ◽  
Fluorescent Molecules

Thio-based photosensitizer: a general strategy for preparing visible/NIR light absorbing heavy-atom-free photosensitizers was developed by performing a simple sulfur-for-oxygen atom substitution within existing fluorescent molecules.

scholarly journals SHG-enhanced NIR-excited in vitro photodynamic therapy using composite nanoparticles of barium titanate and rose Bengal

RSC Advances ◽  
2019 ◽  
Vol 9 (14) ◽  
pp. 8056-8064 ◽  
Author(s):  
Xianhe Sun ◽  
Zhang Ji ◽  
Sailing He
Keyword(s):  
Photodynamic Therapy ◽  
Barium Titanate ◽  
Second Harmonic Generation ◽  
Harmonic Generation ◽  
Rose Bengal ◽  
Near Infrared ◽  
Second Harmonic ◽  
Composite Nanoparticles ◽  
Nir Light

Composite nanoparticles of barium titanate and rose Bengal are used to achieve second harmonic generation (SHG) enhanced photodynamic therapy excited by near infrared (NIR) light.

An upconversion nanoplatform with extracellular pH-driven tumor-targeting ability for improved photodynamic therapy

Nanoscale ◽  
2018 ◽  
Vol 10 (9) ◽  
pp. 4432-4441 ◽  
Author(s):  
Fujin Ai ◽  
Na Wang ◽  
Xiaoman Zhang ◽  
Tianying Sun ◽  
Qi Zhu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Tumor Targeting ◽  
Near Infrared ◽  
Extracellular Ph ◽  
Upconversion Nanoparticles ◽  
Nir Light ◽  
Targeting Ability

Upconversion nanoparticles (UCNPs) are widely utilized for photodynamic therapy (PDT) due to their specific upconverting luminescence that utilizes near infrared (NIR) light to excite photosensitizers (PSs) for PDT.

Vitamin B2-Initiated Hydroxyl Radical Generation under Visible Light in the Presence of Dissolved Iron

2015 ◽  
Vol 3 (8) ◽  
pp. 1756-1763 ◽  
Author(s):  
Fang Xu ◽  
Xiang-Ning Song ◽  
Guo-Ping Sheng ◽  
Hong-Wei Luo ◽  
Wen-Wei Li ◽  
...  
Keyword(s):  
Visible Light ◽  
Hydroxyl Radical ◽  
Vitamin B2 ◽  
Dissolved Iron ◽  
Radical Generation

scholarly journals Near Infrared Fluorescent Nanostructure Design for Organic/Inorganic Hybrid System

Biomedicines ◽  
2021 ◽  
Vol 9 (11) ◽  
pp. 1583
Author(s):  
Kyohei Okubo ◽  
Masakazu Umezawa ◽  
Kohei Soga
Keyword(s):  
Photodynamic Therapy ◽  
Near Infrared ◽  
Vibrational Energy ◽  
Organic Dyes ◽  
Inorganic Nanoparticles ◽  
Hybrid Nanostructures ◽  
Inorganic Hybrid ◽  
Luminescence Centers ◽  
Nir Light

Near infrared (NIR) light offers high transparency in biological tissue. Recent advances in NIR fluorophores including organic dyes and lanthanide-doped inorganic nanoparticles have realized the effective use of the NIR optical window for in vivo bioimaging and photodynamic therapy. The narrow energy level intervals used for electronic transition that involves NIR light, however, give rise to a need for guidelines for reducing heat emission in luminescence systems, especially in the development of organic/inorganic hybrid structures. This review presents an approach for employing the polarity and vibrational energy of ions and molecules that surround the luminescence centers for the development of such hybrid nanostructures. Multiphonon relaxation theory, formulated for dealing with heat release in ionic solids, is applied to describe the vibrational energy in organic or molecular systems, referred to as phonon in this review, and we conclude that surrounding the luminescence centers either with ions with low vibrational energy or molecules with small chemical polarity is the key to bright luminescence. NIR photoexcited phosphors and nanostructures in organic/inorganic mixed systems, designed based on the guidelines, for photodynamic therapy are reviewed.

scholarly journals Self-assembled CeVO4/Au heterojunction nanocrystals for photothermal/photoacoustic bimodal imaging-guided phototherapy

RSC Advances ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. 2581-2588 ◽  
Author(s):  
Junrong Wang ◽  
Yubo Hu ◽  
Junyang Chen ◽  
Cong Ye
Keyword(s):  
Photodynamic Therapy ◽  
Near Infrared ◽  
Anticancer Agent ◽  
Nir Light ◽  
Bimodal Imaging ◽  
Self Assembled

CeVO4/Au NCs can be used as an effective photothermal/photoacoustic bimodal imaging-guided theranostic anticancer agent for near-infrared (NIR) light-mediated photothermal/photodynamic therapy.

Energy Transfer Facilitated Near Infrared Fluorescence Imaging and Photodynamic Therapy of Tumor

2021 ◽  
Author(s):  
Yanjing Wang ◽  
Xiujuan Sun ◽  
Yun Chang ◽  
Haiyuan Zhang
Keyword(s):  
Photodynamic Therapy ◽  
Energy Transfer ◽  
Fluorescence Imaging ◽  
Near Infrared ◽  
Tumor Treatment ◽  
Near Infrared Fluorescence ◽  
Nir Light ◽  
Near Infrared Fluorescence Imaging

Near infrared (NIR) light activated fluorescence imaging and photodynamic therapy hold great potential for tumor treatment in deep tissues. Development of effective theranostic nanosystems to integrate both functions is becoming...

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