scholarly journals Single-atom replacement as a general approach towards visible-light/near-infrared heavy-atom-free photosensitizers for photodynamic therapy

2020 ◽  
Vol 11 (26) ◽  
pp. 6701-6708 ◽  
Author(s):  
Juan Tang ◽  
Lushun Wang ◽  
Axel Loredo ◽  
Carson Cole ◽  
Han Xiao
Keyword(s):  
Photodynamic Therapy ◽  
Oxygen Atom ◽  
Visible Light ◽  
Near Infrared ◽  
Heavy Atom ◽  
Single Atom ◽  
General Strategy ◽  
Nir Light ◽  
Fluorescent Molecules

Thio-based photosensitizer: a general strategy for preparing visible/NIR light absorbing heavy-atom-free photosensitizers was developed by performing a simple sulfur-for-oxygen atom substitution within existing fluorescent molecules.

Biodegradable Nano-photosensitizer with Photoactivatable Singlet Oxygen Generation for Synergistic Phototherapy

2021 ◽  
Author(s):  
Jiaxin Shen ◽  
Dandan Chen ◽  
Ye Liu ◽  
Guoyang Gao ◽  
Zhihe Liu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Cancer Therapy ◽  
Singlet Oxygen ◽  
Near Infrared ◽  
Promising Method ◽  
Normal Cells ◽  
Oxygen Generation ◽  
Singlet Oxygen Generation ◽  
Nir Light

Photodynamic therapy (PDT) is a promising method for cancer therapy and also may initiate unexpected damages to normal cells and tissues. Herein, we developed a near-infrared (NIR) light-activatable nanophotosensitizer, which...

Heavy atom substituted near-infrared BODIPY nanoparticles for photodynamic therapy

2020 ◽  
Vol 178 ◽  
pp. 108348 ◽  
Author(s):  
Yuandong Zhang ◽  
Zhiyu Yang ◽  
Xiaohua Zheng ◽  
Lu Yang ◽  
Nan Song ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Near Infrared ◽  
Heavy Atom

Ultralow-intensity near infrared light synchronously activated collaborative chemo/photothermal/photodynamic therapy

2020 ◽  
Vol 8 (2) ◽  
pp. 607-618 ◽  
Author(s):  
Renlu Han ◽  
Keqi Tang ◽  
Yafei Hou ◽  
Jiancheng Yu ◽  
Chenlu Wang ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Near Infrared ◽  
Infrared Light ◽  
Near Infrared Light ◽  
Nir Light

An ultralow-intensity 808 nm NIR light with 0.25 W cm−2 synchronously activated collaborative Chemo/Photothermal/Photodynamic therapy system was developed.

scholarly journals Near-infrared and visible light dual-mode organic photodetectors

2020 ◽  
Vol 6 (5) ◽  
pp. eaaw8065 ◽  
Author(s):  
Zhaojue Lan ◽  
Yanlian Lei ◽  
Wing Kin Edward Chan ◽  
Shuming Chen ◽  
Dan Luo ◽  
...  
Keyword(s):  
Visible Light ◽  
Reverse Bias ◽  
Near Infrared ◽  
Forward Bias ◽  
Charge Injection ◽  
Light Response ◽  
Dual Mode ◽  
Nir Light ◽  
Light Absorber ◽  
Absorbing Layer

We report a dual-mode organic photodetector (OPD) that has a trilayer visible light absorber/optical spacer/near-infrared (NIR) light absorber configuration. In the presence of NIR light, photocurrent is produced in the NIR light–absorbing layer due to the trap-assisted charge injection at the organic/cathode interface at a reverse bias. In the presence of visible light, photocurrent is produced in the visible light–absorbing layer, enabled by the trap-assisted charge injection at the anode/organic interface at a forward bias. A high responsivity of >10 A/W is obtained in both short and long wavelengths. The dual-mode OPD exhibits an NIR light response operated at a reverse bias and a visible light response operated at a forward bias, with a high specific detectivity of ~1013 Jones in both NIR and visible light ranges. A bias-switchable spectral response OPD offers an attractive option for applications in environmental pollution detection, bioimaging process, wellness, and security monitoring in two distinct bands.

scholarly journals SHG-enhanced NIR-excited in vitro photodynamic therapy using composite nanoparticles of barium titanate and rose Bengal

RSC Advances ◽  
2019 ◽  
Vol 9 (14) ◽  
pp. 8056-8064 ◽  
Author(s):  
Xianhe Sun ◽  
Zhang Ji ◽  
Sailing He
Keyword(s):  
Photodynamic Therapy ◽  
Barium Titanate ◽  
Second Harmonic Generation ◽  
Harmonic Generation ◽  
Rose Bengal ◽  
Near Infrared ◽  
Second Harmonic ◽  
Composite Nanoparticles ◽  
Nir Light

Composite nanoparticles of barium titanate and rose Bengal are used to achieve second harmonic generation (SHG) enhanced photodynamic therapy excited by near infrared (NIR) light.

scholarly journals Higher pulse frequency of near-infrared laser irradiation increases penetration depth for novel biomedical applications

PLoS ONE ◽  
2021 ◽  
Vol 16 (1) ◽  
pp. e0245350
Author(s):  
Ayan Barbora ◽  
Oryan Bohar ◽  
Ariel Alexander Sivan ◽  
Eyal Magory ◽  
Ariel Nause ◽  
...  
Keyword(s):  
Visible Light ◽  
High Frequency ◽  
Near Infrared ◽  
Continuous Wave ◽  
Low Frequency ◽  
Pulse Frequency ◽  
Nir Light ◽  
Cw Laser ◽  
Chicken Tissue ◽  
Penetration Depths

Background The clinical efficiency of laser treatments is limited by the low penetration of visible light used in certain procedures like photodynamic therapy (PDT). Second Harmonic Generation (SHG) PDT is an innovative technique to overcome this limitation that enables the use of Near Infrared (NIR) light instead of visible light. NIR frequency bands present an optical window for deeper penetration into biological tissue. In this research, we compare the penetration depths of 405 and 808 nm continuous wave (CW) lasers and 808 nm pulsed wave (PW) laser in two different modes (high and low frequency). Methods Increasing thicknesses of beef and chicken tissue samples were irradiated under CW and PW lasers to determine penetration depths. Results The 808 nm CW laser penetrates 2.3 and 2.4 times deeper than the 405 nm CW laser in beef and chicken samples, respectively. 808 nm PW (pulse frequency—500 Hz) penetrates deeper than CW laser at the same wavelength. Further, increasing the pulse frequency achieves higher penetration depths. High frequency 808 nm PW (pulse frequency—71.4 MHz) penetrates 7.4- and 6.0-times deeper than 405 nm CW laser in chicken and beef, respectively. Conclusions The results demonstrate the higher penetration depths of high frequency PW laser compared to low frequency PW laser, CW laser of the same wavelength and CW laser with half the wavelength. The results indicate that integrating SHG in the PDT process along with pulsed NIR light may allow the treatment of 6–7 times bigger tumours than conventional PDT using blue light.

An upconversion nanoplatform with extracellular pH-driven tumor-targeting ability for improved photodynamic therapy

Nanoscale ◽  
2018 ◽  
Vol 10 (9) ◽  
pp. 4432-4441 ◽  
Author(s):  
Fujin Ai ◽  
Na Wang ◽  
Xiaoman Zhang ◽  
Tianying Sun ◽  
Qi Zhu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Tumor Targeting ◽  
Near Infrared ◽  
Extracellular Ph ◽  
Upconversion Nanoparticles ◽  
Nir Light ◽  
Targeting Ability

Upconversion nanoparticles (UCNPs) are widely utilized for photodynamic therapy (PDT) due to their specific upconverting luminescence that utilizes near infrared (NIR) light to excite photosensitizers (PSs) for PDT.

A new trick (hydroxyl radical generation) of an old vitamin (B2) for near-infrared-triggered photodynamic therapy

RSC Advances ◽  
2016 ◽  
Vol 6 (104) ◽  
pp. 102647-102656 ◽  
Author(s):  
Fang Xu ◽  
Jin Li ◽  
Ting-ting Zhu ◽  
Sheng-Song Yu ◽  
Chong Zuo ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Hydroxyl Radical ◽  
Near Infrared ◽  
Vitamin B ◽  
Vitamin B2 ◽  
Nir Light ◽  
Radical Generation

A new NIR-light-triggered PDT method has been developed using an old vitamin (vitamin B2) integrated with the upconversion nanotechnology.

Synthesis of CuS nanoplate-containing PDMS film with excellent near-infrared shielding properties

RSC Advances ◽  
2016 ◽  
Vol 6 (23) ◽  
pp. 18881-18890 ◽  
Author(s):  
Wenjun Zhong ◽  
Nuo Yu ◽  
Lisha Zhang ◽  
Zixiao Liu ◽  
Zhaojie Wang ◽  
...  
Keyword(s):  
Visible Light ◽  
Composite Film ◽  
Near Infrared ◽  
Pdms Film ◽  
Nir Light ◽  
Shielding Properties

CuS nanoplates have been developed as a near-infrared (NIR) shielding agent, and the corresponding flexible CuS/PDMS composite film can transmit visible light (400–780 nm) but efficiently block NIR light (780–2500 nm).

scholarly journals Near Infrared Fluorescent Nanostructure Design for Organic/Inorganic Hybrid System

Biomedicines ◽  
2021 ◽  
Vol 9 (11) ◽  
pp. 1583
Author(s):  
Kyohei Okubo ◽  
Masakazu Umezawa ◽  
Kohei Soga
Keyword(s):  
Photodynamic Therapy ◽  
Near Infrared ◽  
Vibrational Energy ◽  
Organic Dyes ◽  
Inorganic Nanoparticles ◽  
Hybrid Nanostructures ◽  
Inorganic Hybrid ◽  
Luminescence Centers ◽  
Nir Light

Near infrared (NIR) light offers high transparency in biological tissue. Recent advances in NIR fluorophores including organic dyes and lanthanide-doped inorganic nanoparticles have realized the effective use of the NIR optical window for in vivo bioimaging and photodynamic therapy. The narrow energy level intervals used for electronic transition that involves NIR light, however, give rise to a need for guidelines for reducing heat emission in luminescence systems, especially in the development of organic/inorganic hybrid structures. This review presents an approach for employing the polarity and vibrational energy of ions and molecules that surround the luminescence centers for the development of such hybrid nanostructures. Multiphonon relaxation theory, formulated for dealing with heat release in ionic solids, is applied to describe the vibrational energy in organic or molecular systems, referred to as phonon in this review, and we conclude that surrounding the luminescence centers either with ions with low vibrational energy or molecules with small chemical polarity is the key to bright luminescence. NIR photoexcited phosphors and nanostructures in organic/inorganic mixed systems, designed based on the guidelines, for photodynamic therapy are reviewed.

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