Energy Transfer Facilitated Near Infrared Fluorescence Imaging and Photodynamic Therapy of Tumor

2021 ◽  
Author(s):  
Yanjing Wang ◽  
Xiujuan Sun ◽  
Yun Chang ◽  
Haiyuan Zhang
Keyword(s):  
Photodynamic Therapy ◽  
Energy Transfer ◽  
Fluorescence Imaging ◽  
Near Infrared ◽  
Tumor Treatment ◽  
Near Infrared Fluorescence ◽  
Nir Light ◽  
Near Infrared Fluorescence Imaging

Near infrared (NIR) light activated fluorescence imaging and photodynamic therapy hold great potential for tumor treatment in deep tissues. Development of effective theranostic nanosystems to integrate both functions is becoming...

Dual functionalized natural biomass carbon dots from lychee exocarp for cancer cell targetable near-infrared fluorescence imaging and photodynamic therapy

Nanoscale ◽  
2018 ◽  
Vol 10 (38) ◽  
pp. 18124-18130 ◽  
Author(s):  
Mingyue Xue ◽  
Jingjin Zhao ◽  
Zhihua Zhan ◽  
Shulin Zhao ◽  
Chuanqing Lan ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Fluorescence Imaging ◽  
Cancer Cell ◽  
Carbon Dots ◽  
Near Infrared ◽  
Biomass Carbon ◽  
Near Infrared Fluorescence ◽  
Near Infrared Fluorescence Imaging

Dual functionalized natural biomass carbon dots from lychee exocarp were fabricated for cancer cell targetable near-infrared fluorescence imaging and photodynamic therapy.

scholarly journals Near-infrared fluorescence imaging and photodynamic therapy with indocyanine green lactosomes has antineoplastic effects for gallbladder cancer

Oncotarget ◽  
2019 ◽  
Vol 10 (54) ◽  
pp. 5622-5631
Author(s):  
Hidehiko Hishikawa ◽  
Masaki Kaibori ◽  
Takumi Tsuda ◽  
Kosuke Matsui ◽  
Tadayoshi Okumura ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Indocyanine Green ◽  
Gallbladder Cancer ◽  
Fluorescence Imaging ◽  
Near Infrared ◽  
Near Infrared Fluorescence ◽  
Near Infrared Fluorescence Imaging

Cytosolic NQO1 Enzyme-Activated Near-Infrared Fluorescence Imaging and Photodynamic Therapy with Polymeric Vesicles

ACS Nano ◽  
2020 ◽  
Vol 14 (2) ◽  
pp. 1919-1935 ◽  
Author(s):  
Chenzhi Yao ◽  
Yamin Li ◽  
Zhixiong Wang ◽  
Chengzhou Song ◽  
Xianglong Hu ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Fluorescence Imaging ◽  
Near Infrared ◽  
Near Infrared Fluorescence ◽  
Polymeric Vesicles ◽  
Near Infrared Fluorescence Imaging

scholarly journals Fucoidan-Based Theranostic Nanogel for Enhancing Imaging and Photodynamic Therapy of Cancer

2020 ◽  
Vol 12 (1) ◽  
Author(s):  
Mi Hyeon Cho ◽  
Yan Li ◽  
Pui-Chi Lo ◽  
Hyeri Lee ◽  
Yongdoo Choi
Keyword(s):  
Endothelial Cells ◽  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Fluorescence Imaging ◽  
Near Infrared ◽  
Near Infrared Fluorescence ◽  
Oxygen Generation ◽  
Photodynamic Therapy Of Cancer ◽  
Near Infrared Fluorescence Imaging

Abstract In this study, a fucoidan-based theranostic nanogel (CFN-gel) consisting of a fucoidan backbone, redox-responsive cleavable linker and photosensitizer is developed to achieve activatable near-infrared fluorescence imaging of tumor sites and an enhanced photodynamic therapy (PDT) to induce the complete death of cancer cells. A CFN-gel has nanomolar affinity for P-selectin, which is overexpressed on the surface of tumor neovascular endothelial cells as well as many other cancer cells. Therefore, a CFN-gel can enhance tumor accumulation through P-selectin targeting and the enhanced permeation and retention effect. Moreover, a CFN-gel is non-fluorescent and non-phototoxic upon its systemic administration due to the aggregation-induced self-quenching in its fluorescence and singlet oxygen generation. After internalization into cancer cells and tumor neovascular endothelial cells, its photoactivity is recovered in response to the intracellular redox potential, thereby enabling selective near-infrared fluorescence imaging and an enhanced PDT of tumors. Since a CFN-gel also shows nanomolar affinity for the vascular endothelial growth factor, it also provides a significant anti-tumor effect in the absence of light treatment in vivo. Our study indicates that a fucoidan-based theranostic nanogel is a new theranostic material for imaging and treating cancer with high efficacy and specificity.

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