G-Quadruplex DNA-binding quaternary alkaloids from Tylophora atrofolliculata

RSC Advances ◽  
2016 ◽  
Vol 6 (115) ◽  
pp. 114135-114142 ◽  
Author(s):  
Cheng-Yu Chen ◽  
Li-Ping Bai ◽  
Zhuo-Feng Ke ◽  
Yan Liu ◽  
Jing-Rong Wang ◽  
...  
Keyword(s):  
Dna Binding ◽  
Binding Capacity ◽  
Telomeric Dna ◽  
Quadruplex Dna ◽  
G Quadruplex

Quaternary alkaloids from T. atrofolliculata with human telomeric DNA G-quadruplex binding capacity.

scholarly journals PhenQE8, a Novel Ligand of the Human Telomeric Quadruplex

2021 ◽  
Vol 22 (2) ◽  
pp. 749
Author(s):  
Patricia B. Gratal ◽  
Julia G. Quero ◽  
Adrián Pérez-Redondo ◽  
Zoila Gándara ◽  
Lourdes Gude
Keyword(s):  
Equilibrium Dialysis ◽  
Resonance Energy Transfer ◽  
Resonance Energy ◽  
The Novel ◽  
X Ray Diffraction ◽  
Telomeric Dna ◽  
Healthy Human ◽  
Quadruplex Dna ◽  
Step Procedure ◽  
G Quadruplex

A novel quadruplex ligand based on 1,10-phenanthroline and incorporating two guanyl hydrazone functionalities, PhenQE8, is reported herein. Synthetic access was gained in a two-step procedure with an overall yield of 61%. X-ray diffraction studies revealed that PhenQE8 can adopt an extended conformation that may be optimal to favor recognition of quadruplex DNA. DNA interactions with polymorphic G-quadruplex telomeric structures were studied by different techniques, such as Fluorescence resonance energy transfer (FRET) DNA melting assays, circular dichroism and equilibrium dialysis. Our results reveal that the novel ligand PhenQE8 can efficiently recognize the hybrid quadruplex structures of the human telomeric DNA, with high binding affinity and quadruplex/duplex selectivity. Moreover, the compound shows significant cytotoxic activity against a selected panel of cultured tumor cells (PC-3, HeLa and MCF-7), whereas its cytotoxicity is considerably lower in healthy human cells (HFF-1 and RPWE-1).

Photophysical, G-quadruplex DNA binding and cytotoxic properties of terpyridine complexes with a naphthalimide ligand

RSC Advances ◽  
2016 ◽  
Vol 6 (43) ◽  
pp. 36923-36931 ◽  
Author(s):  
Zhize Ou ◽  
Yimeng Qian ◽  
Yunyan Gao ◽  
Yunqing Wang ◽  
Guoqiang Yang ◽  
...  
Keyword(s):  
Dna Binding ◽  
A549 Cells ◽  
Nih3t3 Cells ◽  
Quadruplex Dna ◽  
G Quadruplex ◽  
Nuclear Location

The complex3inhibits A549 cells selectively over non-cancerous NIH3T3 cells, which may correlate with its selective G-quadruplex binding and nuclear location.

New dimeric carbazole–benzimidazole mixed ligands for the stabilization of human telomeric G-quadruplex DNA and as telomerase inhibitors. A remarkable influence of the spacer

2015 ◽  
Vol 13 (30) ◽  
pp. 8335-8348 ◽  
Author(s):  
Basudeb Maji ◽  
Krishan Kumar ◽  
K. Muniyappa ◽  
Santanu Bhattacharya
Keyword(s):  
Dna Binding ◽  
Inhibition Activity ◽  
Telomerase Inhibition ◽  
Quadruplex Dna ◽  
Telomerase Inhibitors ◽  
Mixed Ligands ◽  
G Quadruplex

G-quadruplex DNA binding dimeric ligands and their telomerase inhibition activity are reported.

One-step synthesis of methylene-bridged bis-carbazole and evaluation of its antitumor activity and G-quadruplex DNA binding property

2019 ◽  
Vol 90 ◽  
pp. 103074
Author(s):  
Gang Li ◽  
Haodong Tang ◽  
Chuanfeng Liu ◽  
Xiaoyu Liao ◽  
Sicong Li ◽  
...  
Keyword(s):  
Dna Binding ◽  
Antitumor Activity ◽  
Binding Property ◽  
Quadruplex Dna ◽  
G Quadruplex ◽  
Dna Binding Property ◽  
One Step

Aggregation and G-quadruplex DNA-binding study of 6a,12a-diazadibenzo-[ a , g ]fluorenylium derivative

2004 ◽  
Vol 14 (14) ◽  
pp. 3627-3630 ◽  
Author(s):  
Bernard Juskowiak ◽  
Elzbieta Galezowska ◽  
Natalia Koczorowska ◽  
Tadeusz W Hermann
Keyword(s):  
Dna Binding ◽  
Binding Study ◽  
Quadruplex Dna ◽  
G Quadruplex

Perylene Diimide G-Quadruplex DNA Binding Selectivity is Mediated by Ligand Aggregation

2002 ◽  
Vol 12 (3) ◽  
pp. 447-450 ◽  
Author(s):  
Sean M. Kerwin ◽  
Grace Chen ◽  
Jonathan T. Kern ◽  
Pei Wang Thomas
Keyword(s):  
Dna Binding ◽  
Perylene Diimide ◽  
Binding Selectivity ◽  
Quadruplex Dna ◽  
G Quadruplex

The biological activity of G-quadruplex DNA binding papaverine-derived ligand in breast cancer cells

2008 ◽  
Vol 27 (4) ◽  
pp. 289-296 ◽  
Author(s):  
Blazej Rubis ◽  
Mariusz Kaczmarek ◽  
Natalia Szymanowska ◽  
Elzbieta Galezowska ◽  
Andrzej Czyrski ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Biological Activity ◽  
Dna Binding ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Quadruplex Dna ◽  
G Quadruplex

Cyclic ferrocenylnaphthalene diimide derivative as a new class of G-quadruplex DNA binding ligand

2017 ◽  
Vol 27 (2) ◽  
pp. 329-335 ◽  
Author(s):  
Md. Monirul Islam ◽  
Shinobu Sato ◽  
Shingo Shinozaki ◽  
Shigeori Takenaka
Keyword(s):  
Dna Binding ◽  
Quadruplex Dna ◽  
New Class ◽  
G Quadruplex
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