Photophysical, G-quadruplex DNA binding and cytotoxic properties of terpyridine complexes with a naphthalimide ligand

RSC Advances ◽  
2016 ◽  
Vol 6 (43) ◽  
pp. 36923-36931 ◽  
Author(s):  
Zhize Ou ◽  
Yimeng Qian ◽  
Yunyan Gao ◽  
Yunqing Wang ◽  
Guoqiang Yang ◽  
...  
Keyword(s):  
Dna Binding ◽  
A549 Cells ◽  
Nih3t3 Cells ◽  
Quadruplex Dna ◽  
G Quadruplex ◽  
Nuclear Location

The complex3inhibits A549 cells selectively over non-cancerous NIH3T3 cells, which may correlate with its selective G-quadruplex binding and nuclear location.

New dimeric carbazole–benzimidazole mixed ligands for the stabilization of human telomeric G-quadruplex DNA and as telomerase inhibitors. A remarkable influence of the spacer

2015 ◽  
Vol 13 (30) ◽  
pp. 8335-8348 ◽  
Author(s):  
Basudeb Maji ◽  
Krishan Kumar ◽  
K. Muniyappa ◽  
Santanu Bhattacharya
Keyword(s):  
Dna Binding ◽  
Inhibition Activity ◽  
Telomerase Inhibition ◽  
Quadruplex Dna ◽  
Telomerase Inhibitors ◽  
Mixed Ligands ◽  
G Quadruplex

G-quadruplex DNA binding dimeric ligands and their telomerase inhibition activity are reported.

One-step synthesis of methylene-bridged bis-carbazole and evaluation of its antitumor activity and G-quadruplex DNA binding property

2019 ◽  
Vol 90 ◽  
pp. 103074
Author(s):  
Gang Li ◽  
Haodong Tang ◽  
Chuanfeng Liu ◽  
Xiaoyu Liao ◽  
Sicong Li ◽  
...  
Keyword(s):  
Dna Binding ◽  
Antitumor Activity ◽  
Binding Property ◽  
Quadruplex Dna ◽  
G Quadruplex ◽  
Dna Binding Property ◽  
One Step

Aggregation and G-quadruplex DNA-binding study of 6a,12a-diazadibenzo-[ a , g ]fluorenylium derivative

2004 ◽  
Vol 14 (14) ◽  
pp. 3627-3630 ◽  
Author(s):  
Bernard Juskowiak ◽  
Elzbieta Galezowska ◽  
Natalia Koczorowska ◽  
Tadeusz W Hermann
Keyword(s):  
Dna Binding ◽  
Binding Study ◽  
Quadruplex Dna ◽  
G Quadruplex

Perylene Diimide G-Quadruplex DNA Binding Selectivity is Mediated by Ligand Aggregation

2002 ◽  
Vol 12 (3) ◽  
pp. 447-450 ◽  
Author(s):  
Sean M. Kerwin ◽  
Grace Chen ◽  
Jonathan T. Kern ◽  
Pei Wang Thomas
Keyword(s):  
Dna Binding ◽  
Perylene Diimide ◽  
Binding Selectivity ◽  
Quadruplex Dna ◽  
G Quadruplex

The biological activity of G-quadruplex DNA binding papaverine-derived ligand in breast cancer cells

2008 ◽  
Vol 27 (4) ◽  
pp. 289-296 ◽  
Author(s):  
Blazej Rubis ◽  
Mariusz Kaczmarek ◽  
Natalia Szymanowska ◽  
Elzbieta Galezowska ◽  
Andrzej Czyrski ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Biological Activity ◽  
Dna Binding ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Quadruplex Dna ◽  
G Quadruplex

Cyclic ferrocenylnaphthalene diimide derivative as a new class of G-quadruplex DNA binding ligand

2017 ◽  
Vol 27 (2) ◽  
pp. 329-335 ◽  
Author(s):  
Md. Monirul Islam ◽  
Shinobu Sato ◽  
Shingo Shinozaki ◽  
Shigeori Takenaka
Keyword(s):  
Dna Binding ◽  
Quadruplex Dna ◽  
New Class ◽  
G Quadruplex

scholarly journals Exploring the Interaction of Curaxin CBL0137 with G-Quadruplex DNA Oligomers

2021 ◽  
Vol 22 (12) ◽  
pp. 6476
Author(s):  
Sabrina Dallavalle ◽  
Luce M. Mattio ◽  
Roberto Artali ◽  
Loana Musso ◽  
Anna Aviñó ◽  
...  
Keyword(s):  
Dna Binding ◽  
31P Nmr ◽  
Antitumor Activities ◽  
Binding Properties ◽  
Dna Oligomers ◽  
Quadruplex Dna ◽  
Dna Targeting ◽  
G Quadruplex ◽  
Dna Binding Properties ◽  
Insight Into

Curaxins and especially the second-generation derivative curaxin CBL0137 have important antitumor activities in multiple cancers such as glioblastoma, melanoma and others. Although most of the authors suggest that their mechanism of action comes from the activation of p53 and inactivation of NF-kB by targeting FACT, there is evidence supporting the involvement of DNA binding in their antitumor activity. In this work, the DNA binding properties of curaxin CBL0137 with model quadruplex DNA oligomers were studied by 1H NMR, CD, fluorescence and molecular modeling. We provided molecular details of the interaction of curaxin with two G-quadruplex structures, the single repeat of human telomere d(TTAGGGT)4 and the c-myc promoter Pu22 sequence. We also performed 1H and 31P NMR experiments were also performed in order to investigate the interaction with duplex DNA models. Our data support the hypothesis that the interaction of curaxin with G-quadruplex may provide a novel insight into the DNA-binding properties of CBL0137, and it will be helpful for the design of novel selective DNA-targeting curaxin analogues.

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