New dimeric carbazole–benzimidazole mixed ligands for the stabilization of human telomeric G-quadruplex DNA and as telomerase inhibitors. A remarkable influence of the spacer

2015 ◽  
Vol 13 (30) ◽  
pp. 8335-8348 ◽  
Author(s):  
Basudeb Maji ◽  
Krishan Kumar ◽  
K. Muniyappa ◽  
Santanu Bhattacharya
Keyword(s):  
Dna Binding ◽  
Inhibition Activity ◽  
Telomerase Inhibition ◽  
Quadruplex Dna ◽  
Telomerase Inhibitors ◽  
Mixed Ligands ◽  
G Quadruplex

G-quadruplex DNA binding dimeric ligands and their telomerase inhibition activity are reported.

scholarly journals SYNTHESIS, CHARACTERIZATION, DNA BINDING AND ANTIBACTERIAL ACTIVITY OF RUTHENIUM(III) COMPLEX CONTAINING MIXED LIGANDS

2015 ◽  
Vol 2 (1) ◽  
pp. 24-28
Author(s):  
Sampath K ◽  
Jayabalakrishnan C
Keyword(s):  
Antibacterial Activity ◽  
Dna Binding ◽  
Structural Features ◽  
Inhibition Activity ◽  
Spectral Techniques ◽  
Mixed Ligands ◽  
Physico Chemical ◽  
Pharmacological Significance ◽  
Growth Inhibition Activity ◽  
Significant Growth Inhibition

Ruthenium(III) complex, [RuBr2(AsPh3)2L] (where L = (E)-2-(2-chlorobenzylidene)-Nmethylhydrazinecarbothioamide) have been synthesized. Structural features of the complex were determined by various physico-chemical and spectral techniques. DNA binding of the complex was investigated by absorption spectroscopy which indicated that the complex bind to DNA via intercalation and this complex ind strongly than ligand. The complex has shown significant growth inhibition activity against a panel of bacteria which indicating the pharmacological significance of the ruthenium(III) complex.

Photophysical, G-quadruplex DNA binding and cytotoxic properties of terpyridine complexes with a naphthalimide ligand

RSC Advances ◽  
2016 ◽  
Vol 6 (43) ◽  
pp. 36923-36931 ◽  
Author(s):  
Zhize Ou ◽  
Yimeng Qian ◽  
Yunyan Gao ◽  
Yunqing Wang ◽  
Guoqiang Yang ◽  
...  
Keyword(s):  
Dna Binding ◽  
A549 Cells ◽  
Nih3t3 Cells ◽  
Quadruplex Dna ◽  
G Quadruplex ◽  
Nuclear Location

The complex3inhibits A549 cells selectively over non-cancerous NIH3T3 cells, which may correlate with its selective G-quadruplex binding and nuclear location.

One-step synthesis of methylene-bridged bis-carbazole and evaluation of its antitumor activity and G-quadruplex DNA binding property

2019 ◽  
Vol 90 ◽  
pp. 103074
Author(s):  
Gang Li ◽  
Haodong Tang ◽  
Chuanfeng Liu ◽  
Xiaoyu Liao ◽  
Sicong Li ◽  
...  
Keyword(s):  
Dna Binding ◽  
Antitumor Activity ◽  
Binding Property ◽  
Quadruplex Dna ◽  
G Quadruplex ◽  
Dna Binding Property ◽  
One Step

Aggregation and G-quadruplex DNA-binding study of 6a,12a-diazadibenzo-[ a , g ]fluorenylium derivative

2004 ◽  
Vol 14 (14) ◽  
pp. 3627-3630 ◽  
Author(s):  
Bernard Juskowiak ◽  
Elzbieta Galezowska ◽  
Natalia Koczorowska ◽  
Tadeusz W Hermann
Keyword(s):  
Dna Binding ◽  
Binding Study ◽  
Quadruplex Dna ◽  
G Quadruplex

Perylene Diimide G-Quadruplex DNA Binding Selectivity is Mediated by Ligand Aggregation

2002 ◽  
Vol 12 (3) ◽  
pp. 447-450 ◽  
Author(s):  
Sean M. Kerwin ◽  
Grace Chen ◽  
Jonathan T. Kern ◽  
Pei Wang Thomas
Keyword(s):  
Dna Binding ◽  
Perylene Diimide ◽  
Binding Selectivity ◽  
Quadruplex Dna ◽  
G Quadruplex
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