Quantum-chemically-calculated mechanistically interpretable molecular descriptors for drug-action mechanism study – a case study of anthracycline anticancer antibiotics

RSC Advances ◽  
2016 ◽  
Vol 6 (78) ◽  
pp. 74426-74435 ◽  
Author(s):  
Siu-Kwong Pang
Keyword(s):  
Drug Development ◽  
Anticancer Activity ◽  
Molecular Descriptors ◽  
Drug Action ◽  
Mechanism Study ◽  
Action Mechanism ◽  
Action Mechanisms ◽  
Anticancer Antibiotics

Identification of drug-action mechanisms and understanding of chemical substituents affecting the anticancer activity of drugs are important for drug development.

scholarly journals Illuminating drug action by network integration of disease genes: a case study of myocardial infarction

2016 ◽  
Vol 12 (5) ◽  
pp. 1653-1666 ◽  
Author(s):  
Rui-Sheng Wang ◽  
Joseph Loscalzo
Keyword(s):  
Myocardial Infarction ◽  
Cardiovascular Effects ◽  
Drug Action ◽  
Mechanisms Of Action ◽  
Disease Genes ◽  
Network Integration

Illuminating the mechanisms of action of drugs used for myocardial infarction (MI) and the cardiovascular effects of non-MI drugs.

Evolution of Digital Technologies and Use of Virtual Assistants in Drug Development

2019 ◽  
pp. 1-20
Author(s):  
Manu Venugopal
Keyword(s):  
Drug Development ◽  
Digital Health ◽  
Critical Role ◽  
Life Sciences ◽  
Digital Technologies ◽  
Development Phase ◽  
Health Technologies ◽  
Daunting Task ◽  
The World

The drug development phase is one of the most time-consuming and expensive stages in the lifecycle of a drug. Marred by patent expirations, price regulations, complexities in disease conditions, life sciences companies are facing a daunting task to bring new molecular entities into the market. Digital health technologies are playing a critical role in addressing some of the challenges faced during drug development. In this chapter, the author talks about the challenges and key trends in the world of drug development, use of new digital health technologies, and the future of drug development. As an example, the author dives into a specific case study on the use of virtual assistants in clinical trials and the benefits of its usage on patients, healthcare professionals, and life sciences companies.

scholarly journals d-Amino Acid Position Influences the Anticancer Activity of Galaxamide Analogs: An Apoptotic Mechanism Study

2017 ◽  
Vol 18 (3) ◽  
pp. 544 ◽  
Author(s):  
Defa Bai ◽  
Siming Yu ◽  
Shenghui Zhong ◽  
Bingxin Zhao ◽  
Shaoling Qiu ◽  
...  
Keyword(s):  
Amino Acid ◽  
Anticancer Activity ◽  
Amino Acid Position ◽  
Mechanism Study ◽  
Apoptotic Mechanism
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