Ultrasmall polymersomes of poly-α,β-(N-2-hydroxyethyl l-aspartamide)-graft-poly(l-lactic acid) copolymers as a potential drug carrier

RSC Advances ◽  
2016 ◽  
Vol 6 (89) ◽  
pp. 86361-86372 ◽  
Author(s):  
Hyun Jin Lee ◽  
Seung-Hae Kwon ◽  
Kwang-Suk Jang
Keyword(s):  
Drug Delivery ◽  
Lactic Acid ◽  
Size Distribution ◽  
Thermodynamic Stability ◽  
Drug Carrier ◽  
Potential Drug ◽  
Narrow Size Distribution ◽  
High Thermodynamic Stability ◽  
Delivery Platform

Ultrasmall polymersomes are suggested as a drug delivery platform based on their suitable size, narrow size distribution, uniform morphology, and high thermodynamic stability.

scholarly journals Stereocomplex Polylactide for Drug Delivery and Biomedical Applications: A Review

Molecules ◽  
2021 ◽  
Vol 26 (10) ◽  
pp. 2846
Author(s):  
Seung Hyuk Im ◽  
Dam Hyeok Im ◽  
Su Jeong Park ◽  
Justin Jihong Chung ◽  
Youngmee Jung ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Lactic Acid ◽  
Self Assembly ◽  
Biomedical Applications ◽  
Drug Carrier ◽  
Micelle Formation ◽  
Weak Stability ◽  
Critical Fields ◽  
Physical Strength ◽  
Anti Cancer

Polylactide (PLA) is among the most common biodegradable polymers, with applications in various fields, such as renewable and biomedical industries. PLA features poly(D-lactic acid) (PDLA) and poly(L-lactic acid) (PLLA) enantiomers, which form stereocomplex crystals through racemic blending. PLA emerged as a promising material owing to its sustainable, eco-friendly, and fully biodegradable properties. Nevertheless, PLA still has a low applicability for drug delivery as a carrier and scaffold. Stereocomplex PLA (sc-PLA) exhibits substantially improved mechanical and physical strength compared to the homopolymer, overcoming these limitations. Recently, numerous studies have reported the use of sc-PLA as a drug carrier through encapsulation of various drugs, proteins, and secondary molecules by various processes including micelle formation, self-assembly, emulsion, and inkjet printing. However, concerns such as low loading capacity, weak stability of hydrophilic contents, and non-sustainable release behavior remain. This review focuses on various strategies to overcome the current challenges of sc-PLA in drug delivery systems and biomedical applications in three critical fields, namely anti-cancer therapy, tissue engineering, and anti-microbial activity. Furthermore, the excellent potential of sc-PLA as a next-generation polymeric material is discussed.

Preparation and Pharmacokinetics of Candesartan Cilexetil with Polymer Materials in Self-Microemulsifying Drug Delivery Systems

2013 ◽  
Vol 661 ◽  
pp. 104-107
Author(s):  
Rong Rong Li ◽  
Zhi Fei Xie ◽  
Ming Xing Liu ◽  
Hong Da Zhu
Keyword(s):  
Drug Delivery ◽  
Size Distribution ◽  
Drug Delivery Systems ◽  
Candesartan Cilexetil ◽  
Delivery Systems ◽  
Polydispersity Index ◽  
Polymer Materials ◽  
Narrow Size Distribution ◽  
Good Agreement

The candesartan cilexetil SMEDDS with PEG-PLA as long-circulating materials were successfully prepared and characterized by appearance, size and size distribution, morphology of emulsion and stability. The emulsion showed a narrow size distribution, well-proportioned in good agreement with polydispersity index of 0.005 and 3.6 nm diameter. The candesartan cilexetil SMEDDS were precipitated for 30 days at 25 °C or 37 °C. Meanwhile, Pharmacokinetics experiments illuminated that the candesartan cilexetil SMEDDS in rats had a larger drug curve concentration (AUC) compared to the tablets in the experiments.

Tuning of hydrogen peroxide-responsive polymeric micelles of biodegradable triblock polycarbonates as a potential drug delivery platform with ratiometric fluorescence signaling

2015 ◽  
Vol 6 (47) ◽  
pp. 8132-8143 ◽  
Author(s):  
Ying-Hua Fu ◽  
Chun-Yen Chen ◽  
Chao-Tsen Chen
Keyword(s):  
Drug Delivery ◽  
Hydrogen Peroxide ◽  
Polymeric Micelles ◽  
Potential Drug ◽  
Ratiometric Fluorescence ◽  
Delivery Platform ◽  
Fluorescence Signaling

Two micelles of amphiphilic triblock polycarbonates with different H2O2-reactive core-forming blocks manifest disparate H2O2-induced disaggregation behaviors of micelles.

scholarly journals Functionalization of Biotinylated Polyethylene Glycol on Live Magnetotactic Bacteria Carriers for Improved Stealth Properties

Biology ◽  
2021 ◽  
Vol 10 (10) ◽  
pp. 993
Author(s):  
Richa Chaturvedi ◽  
Yumin Kang ◽  
Yunji Eom ◽  
Sri Ramulu Torati ◽  
CheolGi Kim
Keyword(s):  
Magnetic Field ◽  
Drug Delivery ◽  
Polyethylene Glycol ◽  
Drug Carrier ◽  
Magnetotactic Bacteria ◽  
Biological Applications ◽  
Potential Drug ◽  
Time Saving ◽  
Area Of Interest ◽  
Cell Association

The early removal of drug delivery agents before reaching the affected target remains an area of interest to researchers. Several magnetotactic bacteria (MTB) have been used as self-propelled drug delivery agents, and they can also be controlled by an external magnetic field. By attaching the PEG–biotin polymer, the bacteria are turned into a stealth material that can escape from the phagocytosis process and reach the area of interest with the drug load. In the study, we developed a potential drug carrier by attaching the PEG–biotin to the MTB-through-NHS crosslinker to form a MTB/PEG–biotin complex. The attachment stability, efficacy, and bacterial viability upon attachment of the PEG–biotin polymer were investigated. Biological applications were carried out using a cytotoxicity assay of THP-1 cells, and the results indicate that the MTB/PEG–biotin complex is less harmful to cell viability compared to MTB alone. Along with cytotoxicity, an assay for cell association was also evaluated to assess the complex as a potential stealth material. The development of these complexes focuses on an easy, time-saving, and stable technique of polymer attachment with the bacteria, without damaging the cell’s surface, so as to make it a strong and reliable delivery agent.

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