Preparation of Magnetite Nanoparticles Coated with an Amphiphilic Block Copolymer: A Potential Drug Carrier with a Core-Shell-Corona Structure for Hydrophobic Drug Delivery

2006 ◽  
Vol 27 (24) ◽  
pp. 2107-2112 ◽  
Author(s):  
Yunpeng Bai ◽  
Bao Teng ◽  
Shizhen Chen ◽  
Yu Chang ◽  
Zhaolong Li
Keyword(s):  
Drug Delivery ◽  
Block Copolymer ◽  
Magnetite Nanoparticles ◽  
Drug Carrier ◽  
Amphiphilic Block Copolymer ◽  
Core Shell ◽  
Potential Drug ◽  
Hydrophobic Drug ◽  
Corona Structure

A new drug carrier: Magnetite nanoparticles coated with amphiphilic block copolymer

2009 ◽  
Vol 54 (7) ◽  
pp. 1190-1196 ◽  
Author(s):  
Yu Chang ◽  
YunPeng Bai ◽  
Bao Teng ◽  
ZhaoLong Li
Keyword(s):  
Block Copolymer ◽  
Magnetite Nanoparticles ◽  
Drug Carrier ◽  
Amphiphilic Block Copolymer ◽  
New Drug

Hydrogen Sulfide-Activatable Prodrug-Backboned Block Copolymer Micelles for Delivery of Chemotherapeutics

2021 ◽  
Author(s):  
Jiajia Xiang ◽  
Peiwen Xing ◽  
Liu Xin ◽  
Peihong Shen ◽  
Shiqun Shao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Hydrogen Sulfide ◽  
Block Copolymer ◽  
Anticancer Drug ◽  
Amphiphilic Block Copolymer ◽  
Core Shell ◽  
Anticancer Drug Delivery ◽  
Block Copolymer Micelles ◽  
Stable Core ◽  
Copolymer Micelles

Amphiphilic block copolymer prodrugs, which can self-assemble into stable core-shell micelles, have been widely used for anticancer drug delivery. However, a major challenge remains to design drug-conjugating linkers stable in...

scholarly journals Mesoscale Simulations of pH-Responsive Amphiphilic Polymeric Micelles for Oral Drug Delivery

Pharmaceutics ◽  
2019 ◽  
Vol 11 (12) ◽  
pp. 620 ◽  
Author(s):  
Zhimin Wu ◽  
Manzhen Duan ◽  
Di Xiong ◽  
Can Yang Zhang
Keyword(s):  
Drug Delivery ◽  
Block Copolymer ◽  
Self Assembly ◽  
Polymeric Micelles ◽  
Drug Carrier ◽  
Drug Distribution ◽  
Amphiphilic Block Copolymer ◽  
Oral Drug ◽  
Structure Property ◽  
Ph Responsive

It is of great significance to study the structure property and self-assembly of amphiphilic block copolymer in order to effectively and efficiently design and prepare drug delivery systems. In this work, dissipative particle dynamics (DPD) simulation method was used to investigate the structure property and self-assembly ability of pH-responsive amphiphilic block copolymer poly(methyl methacrylate-co-methacrylic acid)-b-poly(aminoethyl methacrylate) (poly(MMA-co-MAA)-b-PAEMA). The effects of different block ratios (hydrophilic PAEMA segment and pH-sensitive PMAA segment) in copolymer on self-assembly and drug loading capacity including drug distribution were extensively investigated. The increase of hydrophilic PAEMA facilitated the formation of a typical core-shell structure as well as a hydrophobic PMAA segment. Furthermore, the optimal drug-carrier ratio was confirmed by an analysis of the drug distribution during the self-assembly process of block copolymer and model drug Ibuprofen (IBU). In addition, the drug distribution and nanostructure of IBU-loaded polymeric micelles (PMs) self-assembled from precise block copolymer (PMMA-b-PMAA-b-PAEMA) and block copolymer (poly(MMA-co-MAA)-b-PAEMA) with random pH-responsive/hydrophobic structure were evaluated, showing that almost all drug molecules were encapsulated into a core for a random copolymer compared to the analogue. The nanostructures of IBU-loaded PMs at different pH values were evaluated. The results displayed that the nanostructure was stable at pH < pKa and anomalous at pH > pKa which indicated drug release, suggesting that the PMs could be used in oral drug delivery. These findings proved that the amphiphilic block copolymer P(MMA30-co-MAA33)-b-PAEMA38 with random structure and pH-sensitivity might be a potential drug carrier. Moreover, DPD simulation shows potential to study the structure property of PMs self-assembled from amphiphilic block copolymer.

PEG-PLA Block Copolymer as Potential Drug Carrier: Preparation and Characterization

2006 ◽  
Vol 6 (12) ◽  
pp. 1019-1025 ◽  
Author(s):  
Shimon Ben-Shabat ◽  
Neeraj Kumar ◽  
Abraham J. Domb
Keyword(s):  
Block Copolymer ◽  
Drug Carrier ◽  
Potential Drug

PREPARATION AND CHARACTERIZATION OF SURFACE-FUNCTIONALIZATION OF SILICA-COATED MAGNETITE NANOPARTICLES FOR DRUG DELIVERY

NANO ◽  
2014 ◽  
Vol 09 (04) ◽  
pp. 1450042 ◽  
Author(s):  
CONG-WANG ZHANG ◽  
CHANG-CHUN ZENG ◽  
YING XU
Keyword(s):  
Drug Delivery ◽  
Shell Structure ◽  
Drug Carrier ◽  
Point Of View ◽  
Core Shell ◽  
Shell Nanoparticles ◽  
The Core ◽  
Application Potential ◽  
Core Shell Structure ◽  
Core Shell Nanoparticles

Fe 3 O 4– SiO 2 core–shell structure nanoparticles containing magnetic properties were investigated for their potential use in drug delivery. The Fe 3 O 4– SiO 2 core–shell structure nanoparticles were successfully synthesized by a simple and convenient way. The Fe 3 O 4– SiO 2 nanoparticles showed superparamagnetic behavior, indicating a great application potential in separation technologies. From the application point of view, the prepared nanoparticles were found to act as an efficient drug carrier. Specifically, the surface of the core–shell nanoparticles was modified with amino groups by use of silane coupling agent 3-aminopropyltriethoxysilane (APTS). Doxorubicin (DOX) was successfully grafted to the surface of the core–shell nanoparticles after the decoration with the carboxyl acid groups on the surface of amino-modified core–shell structure nanoparticles. Moreover, the nanocomposite showed a good drug delivery performance in the DOX-loading efficiency and drug release experiments, confirming that the materials had a great application potential in drug delivery. It is envisioned that the prepared materials are the ideal agent for application in medical diagnosis and therapy.

Citrate modified β-cyclodextrin functionalized magnetite nanoparticles: a biocompatible platform for hydrophobic drug delivery

RSC Advances ◽  
2015 ◽  
Vol 5 (28) ◽  
pp. 22117-22125 ◽  
Author(s):  
Kunnoth N. Jayaprabha ◽  
Pattayil A. Joy
Keyword(s):  
Drug Delivery ◽  
Magnetite Nanoparticles ◽  
Hydrophobic Drug ◽  
Water Dispersible

Water dispersible, β-cyclodextrin functionalized, magnetite nanoparticles are shown to be suitable for the delivery of the hydrophobic drug curcumin, with possible multifunctional applications.

scholarly journals Bioinspired Core–Shell Nanoparticles for Hydrophobic Drug Delivery

2019 ◽  
Vol 131 (40) ◽  
pp. 14495-14502 ◽  
Author(s):  
Guangze Yang ◽  
Yun Liu ◽  
Haofei Wang ◽  
Russell Wilson ◽  
Yue Hui ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Core Shell ◽  
Hydrophobic Drug ◽  
Shell Nanoparticles ◽  
Core Shell Nanoparticles
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