Tuning of hydrogen peroxide-responsive polymeric micelles of biodegradable triblock polycarbonates as a potential drug delivery platform with ratiometric fluorescence signaling

2015 ◽  
Vol 6 (47) ◽  
pp. 8132-8143 ◽  
Author(s):  
Ying-Hua Fu ◽  
Chun-Yen Chen ◽  
Chao-Tsen Chen
Keyword(s):  
Drug Delivery ◽  
Hydrogen Peroxide ◽  
Polymeric Micelles ◽  
Potential Drug ◽  
Ratiometric Fluorescence ◽  
Delivery Platform ◽  
Fluorescence Signaling

Two micelles of amphiphilic triblock polycarbonates with different H2O2-reactive core-forming blocks manifest disparate H2O2-induced disaggregation behaviors of micelles.

scholarly journals Oseltamivir-conjugated polymeric micelles prepared by RAFT living radical polymerization as a new active tumor targeting drug delivery platform

2016 ◽  
Vol 4 (3) ◽  
pp. 511-521 ◽  
Author(s):  
Vitaliy Kapishon ◽  
Stephanie Allison ◽  
Ralph A. Whitney ◽  
Michael F. Cunningham ◽  
Myron R. Szewczuk ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Cells ◽  
Radical Polymerization ◽  
Tumor Targeting ◽  
Polymeric Micelles ◽  
Living Radical Polymerization ◽  
Delivery Platform

Synthetic steps and subsequent preparation of oseltamivir-conjugated micelles capable of targeting and triggering receptor-induced endocytosis in cancer cells.

Ultrasmall polymersomes of poly-α,β-(N-2-hydroxyethyl l-aspartamide)-graft-poly(l-lactic acid) copolymers as a potential drug carrier

RSC Advances ◽  
2016 ◽  
Vol 6 (89) ◽  
pp. 86361-86372 ◽  
Author(s):  
Hyun Jin Lee ◽  
Seung-Hae Kwon ◽  
Kwang-Suk Jang
Keyword(s):  
Drug Delivery ◽  
Lactic Acid ◽  
Size Distribution ◽  
Thermodynamic Stability ◽  
Drug Carrier ◽  
Potential Drug ◽  
Narrow Size Distribution ◽  
High Thermodynamic Stability ◽  
Delivery Platform

Ultrasmall polymersomes are suggested as a drug delivery platform based on their suitable size, narrow size distribution, uniform morphology, and high thermodynamic stability.

Multivesicular liposomes as a potential drug delivery platform for cancer therapy: A systematic review

2021 ◽  
Vol 66 ◽  
pp. 102842
Author(s):  
Seyed Baubak Mostafavi Naeini ◽  
Simin Dadashzadeh ◽  
Azadeh Haeri ◽  
Mohammad A. Mahjoub ◽  
Jaber Javidi ◽  
...  
Keyword(s):  
Systematic Review ◽  
Drug Delivery ◽  
Cancer Therapy ◽  
Potential Drug ◽  
Delivery Platform

Hydrogel-clay Nanocomposites as Carriers for Controlled Release

2020 ◽  
Vol 27 (6) ◽  
pp. 919-954 ◽  
Author(s):  
Raluca Ianchis ◽  
Claudia Mihaela Ninciuleanu ◽  
Ioana Catalina Gifu ◽  
Elvira Alexandrescu ◽  
Cristina Lavinia Nistor ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Hybrid Materials ◽  
Pharmaceutical Formulations ◽  
Tree Of Life ◽  
Present Review ◽  
Clay Nanocomposites ◽  
Delivery Platform ◽  
Complex Hybrid

The present review aims to summarize the research efforts undertaken in the last few years in the development and testing of hydrogel-clay nanocomposites proposed as carriers for controlled release of diverse drugs. Their advantages, disadvantages and different compositions of polymers/biopolymers with diverse types of clays, as well as their interactions are discussed. Illustrative examples of studies regarding hydrogel-clay nanocomposites are detailed in order to underline the progressive researches on hydrogel-clay-drug pharmaceutical formulations able to respond to a series of demands for the most diverse applications. Brief descriptions of the different techniques used for the characterization of the obtained complex hybrid materials such as: swelling, TGA, DSC, FTIR, XRD, mechanical, SEM, TEM and biology tests, are also included. Enlightened by the presented data, we can suppose that hydrogel-clay nanocomposites will still be a challenging subject of global assiduous researches. We can dare to dream to an efficient drug delivery platform for the treatment of multiple affection concomitantly, these being undoubtedly like ”a tree of life” bearing different kinds of fruits and leaves proper for human healing.

Recent Nanocarrier Approaches for Targeted Drug Delivery in Cancer Therapy

2020 ◽  
Vol 13 ◽  
Author(s):  
Rohit Bhatia ◽  
Amit Sharma ◽  
Raj Kumar Narang ◽  
Ravindra K. Rawal
Keyword(s):  
Drug Delivery ◽  
Polymeric Micelles ◽  
Mesoporous Silica Nanoparticles ◽  
Treatment Strategies ◽  
Human Beings ◽  
The Past ◽  
Organ Systems ◽  
Metal Organic ◽  
Continuous Progress ◽  
Chemotherapeutic Treatment

: Cancer is one of the most serious health concerns in 21st century whose prevalence is beyond boundaries and can affect any organ of human beings. The conventional chemotherapeutic treatment strategies lack specificity to tumours and are associated with toxic effects on immune system and other organ systems. In the past decades, there has been a continuous progress in the development of smart nanocarrier systems for target specific delivery of drugs against variety of tumours including intracellular gene-specific targeting. These nanocarriers are able to recognize the tumour cells and deliver the therapeutic agent in fixed proportions causing no or very less harm to healthy cells. Nanosystems have modified physicochemical properties, improved bioavailability and long retention in blood which enhances their potency. A huge number of nanocarrier based formulations have been developed and are in clinical trials. Nanocarrier systems include polymeric micelles, liposomes, dendrimers, carbon nanotubes, gold nanoparticles, etc. Recent advancements in nanocarrier systems include mesoporous silica nanoparticles (MSNs), metal organic frame works and quantum dots. In the present review, various nanocarrier based drug delivery systems along with their applications in the management of cancer have been described with special emphasis on MSNs.

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