Development of N,S-doped carbon dots as a novel matrix for the analysis of small molecules by negative ion MALDI-TOF MS

RSC Advances ◽  
2016 ◽  
Vol 6 (82) ◽  
pp. 79043-79049 ◽  
Author(s):  
Yanwei Wang ◽  
Dan Gao ◽  
Yongli Chen ◽  
Guangnan Hu ◽  
Hongxia Liu ◽  
...  
Keyword(s):  
Salt Tolerance ◽  
Small Molecules ◽  
Carbon Dots ◽  
High Sensitivity ◽  
Negative Ion ◽  
Good Reproducibility ◽  
High Salt Tolerance ◽  
Small Molecule Analysis ◽  
Doped Carbon Dots ◽  
Tof Ms

The synthesized N,S-CDs was firstly used as a matrix for small molecule analysis with good reproducibility, high sensitivity and high salt tolerance.

scholarly journals N-(1-Naphthyl) Ethylenediamine Dinitrate: A New Matrix for Negative Ion MALDI-TOF MS Analysis of Small Molecules

2012 ◽  
Vol 23 (9) ◽  
pp. 1454-1460 ◽  
Author(s):  
Rui Chen ◽  
Suming Chen ◽  
Caiqiao Xiong ◽  
Xunlei Ding ◽  
Chih-Che Wu ◽  
...  
Keyword(s):  
Small Molecules ◽  
Negative Ion ◽  
Maldi Tof Ms ◽  
Maldi Tof ◽  
Ms Analysis ◽  
Tof Ms

scholarly journals Detection of Melamine Based on the Fluorescence Changes of Nitrogen-Doped Carbon Dots

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Wenzhi Yin ◽  
Chaoqun Ma ◽  
Tuo Zhu ◽  
Jiao Gu ◽  
Chun Zhu ◽  
...  
Keyword(s):  
Carbon Dots ◽  
Detection Method ◽  
Limit Of Detection ◽  
High Sensitivity ◽  
Mercury Ions ◽  
Measuring Range ◽  
Nitrogen Doped ◽  
One Step ◽  
Doped Carbon Dots ◽  
Nitrogen Doped Carbon

In order to determine the concentration of melamine, nitrogen-doped carbon dots (NCDs) were synthesized in one step as a fluorescent probe. Uric acid and diethylenetriamine were used as carbon source and nitrogen source, respectively. The experimental results showed that the fluorescence of NCDs can be quenched by mercury ions (Hg2+). Due to the strong coordination affinity between the carbon-nitrogen heterocyclic of melamine and Hg2+, part of Hg2+ coordinated with melamine when melamine was mixed with Hg2+. Then, the fluorescence of the added NCDs was quenched by the remaining Hg2+. Therefore, the concentration of melamine could be determined. The results show that the method has high sensitivity in wide measuring range that the linear ranges are 50–400 μg/L and 800–2500 μg/L, and the R2 is 0.997 and 0.988, respectively, with the limit of detection (LOD) of 21.76 μg/L. The NCDs are easy to fabricate, and the detection method is easy to implement. In this study, a new method for melamine detection was established, and the proposed method for melamine detection can provide some insights for food safety detection.

CuFe2O4 magnetic nanocrystal clusters as a matrix for the analysis of small molecules by negative-ion matrix-assisted laser desorption/ionization time-of-flight mass spectrometry

The Analyst ◽  
2015 ◽  
Vol 140 (15) ◽  
pp. 5287-5294 ◽  
Author(s):  
Zian Lin ◽  
Jiangnan Zheng ◽  
Wei Bian ◽  
Zongwei Cai
Keyword(s):  
Small Molecules ◽  
Laser Desorption ◽  
Negative Ion ◽  
Laser Desorption Ionization ◽  
Ionization Time ◽  
Flight Mass Spectrometry ◽  
High Salt Tolerance ◽  
Magnetic Nanocrystal ◽  
Matrix Assisted Laser ◽  
Matrix Assisted Laser Desorption

CuFe2O4 MNCs were proposed as a new matrix for negative ion MALDI-TOF MS, which exhibited interference-free background, high salt tolerance and good reproducibility for analysis of small molecules.

N-doped graphene quantum dots as a novel highly-efficient matrix for the analysis of perfluoroalkyl sulfonates and other small molecules by MALDI-TOF MS

2017 ◽  
Vol 9 (13) ◽  
pp. 2014-2020 ◽  
Author(s):  
Ziyu Rao ◽  
Fanglan Geng ◽  
Yiqi Zhou ◽  
Dong Cao ◽  
Yuehui Kang
Keyword(s):  
Quantum Dots ◽  
Small Molecules ◽  
Small Molecule ◽  
Graphene Quantum Dots ◽  
Maldi Tof Ms ◽  
Maldi Matrix ◽  
Maldi Tof ◽  
Doped Graphene ◽  
Small Molecule Analysis ◽  
Tof Ms

N-doped graphene quantum dots (N-GQDs) were sythesized by a facile method and applied as a MALDI matrix for small-molecule analysis.

DBDA as a Novel Matrix for the Analyses of Small Molecules and Quantification of Fatty Acids by Negative Ion MALDI-TOF MS

2018 ◽  
Vol 29 (4) ◽  
pp. 704-710 ◽  
Author(s):  
Ling Ling ◽  
Ying Li ◽  
Sheng Wang ◽  
Liming Guo ◽  
Chunsheng Xiao ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Small Molecules ◽  
Negative Ion ◽  
Maldi Tof Ms ◽  
Maldi Tof ◽  
Tof Ms

A Novel Method of Synthesis of Fluorescent Carbon Dots for Supersensitive and Selective Detection of Cancer Markers

2018 ◽  
Vol 18 (12) ◽  
pp. 8085-8093
Author(s):  
Jianrong Qi ◽  
Meixin Hu ◽  
Hongxia Li ◽  
Ruan Jing ◽  
Guangxia Shen
Keyword(s):  
Carbon Dots ◽  
Large Scale ◽  
High Efficiency ◽  
Reaction Medium ◽  
High Sensitivity ◽  
Heating Time ◽  
Serum Samples ◽  
Cancer Markers ◽  
N Doping ◽  
Doped Carbon Dots

Due to the dual role as an electron acceptor and an electron donor in solution, carbon dots (Cdots) have broad applications in environmental analysis, biological detection, and biosensors. Herein, we report a facile-green strategy for a large-scale synthesis of fluorescent N, P-doped carbon dots (N, P-Cdots) with an absolute quantum yield of 66.08% by a simple one-step thermal decomposition. Glucose was selected as a carbon precursor and tryptophan (Trp) as an N-doping and passivation reagent. Organic polar solvents with a high boiling point, i.e., ethylene glycol and glycerol, were used as the reaction medium, and phosphoric acid was employed as a P source and oxidation accelerator. It is shown that the emission wavelength of the N, P-Cdots can be tuned by adjusting the reaction conditions, such as mass ratio, heating time, temperature, and medium, without further passivation. Finally, advantage was taken of the superior fluorescent characteristics of N, P-Cdots to detect selectively and with high sensitivity a cancer marker, carcinoembryonic antigen (CEA), based on the fluorescent quenching mechanism. Additionally, CEA was also detected in human serum samples with high efficiency and RSD, further confirming that the proposed method has a good consistency and stability for supersensitive fluorimetric detection of cancer markers.

scholarly journals Aptamer Turn-On SERS/RRS/Fluorescence Tri-mode Platform for Ultra-trace Urea Determination Using Fe/N-Doped Carbon Dots

2021 ◽  
Vol 9 ◽  
Author(s):  
Chongning Li ◽  
Jiao Li ◽  
Aihui Liang ◽  
Guiqing Wen ◽  
Zhiliang Jiang
Keyword(s):  
Carbon Dots ◽  
Rayleigh Scattering ◽  
High Sensitivity ◽  
Resonance Rayleigh Scattering ◽  
Indicator Reaction ◽  
Turn On ◽  
Surface Enhanced Raman ◽  
Ultra Trace ◽  
Doped Carbon Dots

Sensitive and selective methods for the determination of urea in samples such as dairy products are important for quality control and health applications. Using ammonium ferric citrate as a precursor, Fe/N-codoped carbon dots (CDFeN) were prepared by a hydrothermal procedure and characterized in detail. CDFeN strongly catalyzes the oxidation of 3,3′,5,5′-tetramethylbenzidine (TMB) by H2O2 to turn on an indicator molecular reaction, forming an oxidized tetramethylbenzidine (TMBox) probe with surface-enhanced Raman scattering, resonance Rayleigh scattering, and fluorescence (SERS, RRS, and FL) signals at 1,598 cm−1, 370 nm, and 405 nm, respectively. The urea aptamer (Apt) can turn off the indicator reaction to reduce the tri-signals, and the addition of urea turns on the indicator reaction to linearly enhance the SERS/RRS/FL intensity. Thus, a novel Apt turn-on tri-mode method was developed for the assay determination of ultra-trace urea with high sensitivity, good selectivity, and accuracy. Trace adenosine triphosphate and estradiol can also be determined by the Apt-CDFeN catalytic analytical platform.

N-doped carbon dots with high sensitivity and selectivity for hypochlorous acid detection and its application in water

2015 ◽  
Vol 7 (12) ◽  
pp. 5311-5317 ◽  
Author(s):  
Dongmei Wang ◽  
Hui Xu ◽  
Baozhan Zheng ◽  
Yang Li ◽  
Maoping Liu ◽  
...  
Keyword(s):  
Carbon Dots ◽  
Hypochlorous Acid ◽  
High Sensitivity ◽  
Sensitivity And Selectivity ◽  
Doped Carbon Dots

The as-prepared N-doped CDs were applied as a HOCl sensor with high sensitivity and selectivity.

N-Doped Graphene: An Alternative Carbon-Based Matrix for Highly Efficient Detection of Small Molecules by Negative Ion MALDI-TOF MS

2014 ◽  
Vol 86 (18) ◽  
pp. 9122-9130 ◽  
Author(s):  
Qianhao Min ◽  
Xiaoxia Zhang ◽  
Xueqin Chen ◽  
Siyuan Li ◽  
Jun-Jie Zhu
Keyword(s):  
Small Molecules ◽  
Negative Ion ◽  
Maldi Tof Ms ◽  
Highly Efficient ◽  
Maldi Tof ◽  
Efficient Detection ◽  
Doped Graphene ◽  
Tof Ms ◽  
Carbon Based
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