Facile preparation of hyaluronic acid-modified Fe3O4@Mn3O4 nanocomposites for targeted T1/T2 dual-mode MR imaging of cancer cells

RSC Advances ◽  
2016 ◽  
Vol 6 (42) ◽  
pp. 35295-35304 ◽  
Author(s):  
Jingchao Li ◽  
Yong Hu ◽  
Wenjie Sun ◽  
Yu Luo ◽  
Xiangyang Shi ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Mr Imaging ◽  
Cancer Cells ◽  
Dual Mode ◽  
Facile Preparation

HA-Modified Fe3O4@Mn3O4 nanocomposites with both r2 and r1 relaxivities can be prepared for T1/T2 dual-mode MR imaging of cancer cells.

Facile preparation of hyaluronic acid and transferrin co-modified Fe3O4nanoparticles with inherent biocompatibility for dual-targeting magnetic resonance imaging of tumors in vivo

2015 ◽  
Vol 44 (46) ◽  
pp. 19836-19843 ◽  
Author(s):  
Jinbin Pan ◽  
Shao-Kai Sun ◽  
Yaqiong Wang ◽  
Yan-Yan Fu ◽  
Xuejun Zhang ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Hyaluronic Acid ◽  
Magnetic Resonance ◽  
Mr Imaging ◽  
Resonance Imaging ◽  
Dual Targeting ◽  
Facile Preparation

A biocompatible and sensitive dual-targeting Fe3O4nanoprobe co-modified with biosafe hyaluronic acid and transferrin was developed for tumor-targeted MR imaging.

scholarly journals A nanoselenium-coating biomimetic cytomembrane nanoplatform for mitochondrial targeted chemotherapy- and chemodynamic therapy through manganese and doxorubicin codelivery

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Jianmin Xiao ◽  
Miao Yan ◽  
Ke Zhou ◽  
Hui Chen ◽  
Zhaowei Xu ◽  
...  
Keyword(s):  
Cell Membrane ◽  
Cancer Cells ◽  
High Yield ◽  
Ros Generation ◽  
Superoxide Dismutase 1 ◽  
Nuclear Targeting ◽  
Dual Mode ◽  
Red Cell Membrane ◽  
Cancer Cell Death ◽  
Drug Nanocarriers

Abstract The cell membrane is widely considered as a promising delivery nanocarrier due to its excellent properties. In this study, self-assembled Pseudomonas geniculate cell membranes were prepared with high yield as drug nanocarriers, and named BMMPs. BMMPs showed excellent biosafety, and could be more efficiently internalized by cancer cells than traditional red cell membrane nanocarriers, indicating that BMMPs could deliver more drug into cancer cells. Subsequently, the BMMPs were coated with nanoselenium (Se), and subsequently loaded with Mn2+ ions and doxorubicin (DOX) to fabricate a functional nanoplatform (BMMP-Mn2+/Se/DOX). Notably, in this nanoplatform, Se nanoparticles activated superoxide dismutase-1 (SOD-1) expression and subsequently up-regulated downstream H2O2 levels. Next, the released Mn2+ ions catalyzed H2O2 to highly toxic hydroxyl radicals (·OH), inducing mitochondrial damage. In addition, the BMMP-Mn2+/Se nanoplatform inhibited glutathione peroxidase 4 (GPX4) expression and further accelerated intracellular reactive oxygen species (ROS) generation. Notably, the BMMP-Mn2+/Se/DOX nanoplatform exhibited increased effectiveness in inducing cancer cell death through mitochondrial and nuclear targeting dual-mode therapeutic pathways and showed negligible toxicity to normal organs. Therefore, this nanoplatform may represent a promising drug delivery system for achieving a safe, effective, and accurate cancer therapeutic plan.

scholarly journals Macrophage-Laden Gold Nanoflowers Embedded with Ultrasmall Iron Oxide Nanoparticles for Enhanced Dual-Mode CT/MR Imaging of Tumors

Pharmaceutics ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 995
Author(s):  
Yucheng Peng ◽  
Xiaomeng Wang ◽  
Yue Wang ◽  
Yue Gao ◽  
Rui Guo ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Mr Imaging ◽  
Iron Oxide Nanoparticles ◽  
Colloidal Stability ◽  
Pamam Dendrimer ◽  
Great Promise ◽  
Oxide Nanoparticles ◽  
Dual Mode ◽  
Gold Nanoflowers ◽  
Average Size

The design of multimodal imaging nanoplatforms with improved tumor accumulation represents a major trend in the current development of precision nanomedicine. To this end, we report herein the preparation of macrophage (MA)-laden gold nanoflowers (NFs) embedded with ultrasmall iron oxide nanoparticles (USIO NPs) for enhanced dual-mode computed tomography (CT) and magnetic resonance (MR) imaging of tumors. In this work, generation 5 poly(amidoamine) (G5 PAMAM) dendrimer-stabilized gold (Au) NPs were conjugated with sodium citrate-stabilized USIO NPs to form hybrid seed particles for the subsequent growth of Au nanoflowers (NFs). Afterwards, the remaining terminal amines of dendrimers were acetylated to form the dendrimer-stabilized Fe3O4/Au NFs (for short, Fe3O4/Au DSNFs). The acquired Fe3O4/Au DSNFs possess an average size around 90 nm, display a high r1 relaxivity (1.22 mM−1 s−1), and exhibit good colloidal stability and cytocompatibility. The created hybrid DSNFs can be loaded within MAs without producing any toxicity to the cells. Through the mediation of MAs with a tumor homing and immune evasion property, the Fe3O4/Au DSNFs can be delivered to tumors more efficiently than those without MAs after intravenous injection, thus significantly improving the MR/CT imaging performance of tumors. The developed MA-mediated delivery system may hold great promise for enhanced tumor delivery of other contrast agents or nanomedicines for precision cancer nanomedicine applications.

scholarly journals Comparison Direct Synthesis of Hyaluronic Acid-Based Carbon Nanodots as Dual Active Targeting and Imaging of HeLa Cancer Cells

ACS Omega ◽  
2021 ◽  
Author(s):  
Yu-Yu Aung ◽  
Aswandi Wibrianto ◽  
Jefry S. Sianturi ◽  
Desita K. Ulfa ◽  
Satya. C. W. Sakti ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Cancer Cells ◽  
Direct Synthesis ◽  
Active Targeting ◽  
Carbon Nanodots

An in vitro hyaluronic acid hydrogel based platform to model dormancy in brain metastatic breast cancer cells

2020 ◽  
Vol 107 ◽  
pp. 65-77 ◽  
Author(s):  
Akshay A. Narkhede ◽  
James H. Crenshaw ◽  
David K. Crossman ◽  
Lalita A. Shevde ◽  
Shreyas S. Rao
Keyword(s):  
Breast Cancer ◽  
Hyaluronic Acid ◽  
Metastatic Breast Cancer ◽  
Cancer Cells ◽  
Breast Cancer Cells ◽  
Metastatic Breast ◽  
Hyaluronic Acid Hydrogel

Two-Photon Fluorescence and MR Bio-imaging of Endogenous H2O2 in Tumor Microenvironment by a Dual-Mode Nanoprobe

2021 ◽  
Author(s):  
Hongmei Zhong ◽  
Shengrong Yu ◽  
Bingqian Li ◽  
Kangdi He ◽  
Dian Li ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Tumor Microenvironment ◽  
Mr Imaging ◽  
High Selectivity ◽  
Carbon Quantum Dots ◽  
Dual Mode ◽  
Two Photon ◽  
Bio Imaging ◽  
Two Photon Fluorescence ◽  
Photon Fluorescence

Dual-mode bio-imaging nanoprobe TP-CQDs@MnO2, based two-photon carbon quantum dots and MnO2, has been developed for two-photon fluorescence and MR imaging of endogenous H2O2 in tumor microenvironment, which achieved high selectivity,...

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