Microwave-assisted rapid synthesis of sugar-based pyrazole derivatives with anticancer activity in water

RSC Advances ◽  
2016 ◽  
Vol 6 (71) ◽  
pp. 66803-66806 ◽  
Author(s):  
Kui Du ◽  
Chengcai Xia ◽  
Mengyi Wei ◽  
Xinzhi Chen ◽  
Pengfei Zhang
Keyword(s):  
Microwave Irradiation ◽  
Anticancer Activity ◽  
Pyrazole Derivatives ◽  
Rapid Synthesis ◽  
Green Method ◽  
Microwave Assisted

A rapid, efficient and green method has been developed for the synthesis of some novel sugar-based pyrazole derivatives in eco-friendly water under microwave irradiation in good yields.

scholarly journals A facile microwave-assisted protocol for rapid synthesis of N-acetylneuraminic acid congeners

2014 ◽  
Vol 38 (2) ◽  
pp. 507-510 ◽  
Author(s):  
Jonel P. Saludes ◽  
Dhananjaya Sahoo ◽  
I. Abrrey Monreal
Keyword(s):  
Microwave Irradiation ◽  
Rapid Synthesis ◽  
Acetylneuraminic Acid ◽  
Microwave Assisted

Microwave irradiation offers expedient access to important Neu5ac derivatives at rates that are 1- to 2-orders of magnitude faster than conventional techniques.

Microwave-assisted, palladium-catalyzed carbonylative cyclization — Rapid synthesis of 2-quinolones from unprotected 2-iodoanilines and terminal alkynes

2010 ◽  
Vol 88 (4) ◽  
pp. 331-337 ◽  
Author(s):  
Jia-Rong Chen ◽  
Jie Liao ◽  
Wen-Jing Xiao
Keyword(s):  
Carbon Monoxide ◽  
Microwave Irradiation ◽  
Molybdenum Hexacarbonyl ◽  
Terminal Alkynes ◽  
Solid Carbon ◽  
Rapid Synthesis ◽  
Microwave Assisted ◽  
Palladium Catalyzed ◽  
Quinolone Derivatives

Palladium-catalyzed cyclocarbonylations of 2-iodoanilines with various terminal alkynes have been carried out by the use of commercially available molybdenum hexacarbonyl as a convenient and solid carbon monoxide source. The reactions were conducted at 160 °C for 30 min under microwave irradiation and in the presence of Et3N in THF, affording the corresponding 2-quinolone derivatives in good regioselectivities and yields.

Microwave Assisted Synthesis of Isoquercitrin Using Enzymatic Hydrolysis of Rutin

2014 ◽  
Vol 1033-1034 ◽  
pp. 311-314 ◽  
Author(s):  
Jun Wang ◽  
Guo Xia Sun ◽  
An Gong ◽  
Xiang Yang Wu
Keyword(s):  
Reaction Time ◽  
Enzymatic Hydrolysis ◽  
Microwave Irradiation ◽  
Microwave Assisted Synthesis ◽  
Rapid Synthesis ◽  
Reaction Efficiency ◽  
Microwave Assisted ◽  
Hydrolysis Of

A novel and rapid synthesis of isoquercitrin using enzymatic hydrolysis of rutin under microwave irradiation was investigated. In the [Bmim][BF4]-buffer (pH 9.0) system under microwave irradiation, rutin conversion, isoquercitrin yield and quercetin yield were 89.18%, 84.74% and 2.79%, respectively, in conditions of 5 min and 30 °C. The preparation cost of isoquercitrin was significantly reduced by decreasing reaction time (from 10 h to 5 min) and increasing reaction efficiency (by 120 times).

scholarly journals Microwave-Assisted Synthesis of 3,5-Dibenzyl-4-amino-1,2,4-triazole and its Diazo Ligand, Metal Complexes Along with Anticancer Activity

2010 ◽  
Vol 7 (4) ◽  
pp. 1571-1577 ◽  
Author(s):  
Anjali Jha ◽  
Y. L. N. Murthy ◽  
G. Durga ◽  
T. T. Sundari
Keyword(s):  
Microwave Irradiation ◽  
Metal Complexes ◽  
Anticancer Activity ◽  
Cell Lines ◽  
Conventional Method ◽  
Ruthenium Complexes ◽  
Microwave Assisted Synthesis ◽  
Microwave Irradiation Method ◽  
Anticancer Activities ◽  
Microwave Assisted

Synthesis of 3,5-dibenzyl-4-amino-1,2,4-triazole was accomplished via a conventional method as well as microwave irradiation method, followed by diazotization and coupling with 2,4-pentanedione. The dinucleating ligand was isolated and complexed with Ni(II), Cu(II) and Ru(III) chlorides. These complexes were screened on Jurkat, Raji & PBMC cell lines for anticancer activity. Ruthenium complexes showed potential anticancer activities.

scholarly journals Microwave-assisted rapid synthesis of a polyether from a plant oil derived monomer and its optimization by Box–Behnken design

RSC Advances ◽  
2017 ◽  
Vol 7 (45) ◽  
pp. 27946-27959 ◽  
Author(s):  
Reza Ahmadi ◽  
Aman Ullah
Keyword(s):  
Microwave Irradiation ◽  
Conventional Method ◽  
Plant Oil ◽  
Rapid Synthesis ◽  
Box Behnken Design ◽  
Microwave Assisted ◽  
New Strategy

In this study, a new strategy for making biopolyethers from plant oil derived monomer (α-olefin) was developed using microwave irradiation, conditions were optimized and compared with a conventional method.

scholarly journals Microwave-assisted multi-component synthesis of 3’-indolyl substituted pyrano[2,3-c]pyrazoles and their antimicrobial activity

2012 ◽  
Vol 77 (8) ◽  
pp. 983-991 ◽  
Author(s):  
Harshad Kathrotiya ◽  
Ranjan Patel ◽  
Manish Patel
Keyword(s):  
Antimicrobial Activity ◽  
Reaction Time ◽  
Microwave Irradiation ◽  
High Yield ◽  
Pyrazole Derivatives ◽  
Human Pathogens ◽  
Broth Microdilution ◽  
E Coli ◽  
Microwave Assisted ◽  
Derivatives Of

A series of pyrano[2,3-c]pyrazole derivatives of indole has been synthesized by multi-component reaction using conventional and microwave irradiation approach. Particularly valuable features of this method include high yield, broad substrate scope, shorter reaction time and straightforward procedure. Antimicrobial screening against eight human pathogens, namely B. subtilis, C. tetani, S. pneumoniae, S. typhi, V. cholerae, E. coli, A. fumigatus and C. albicans by employing broth microdilution MIC method as recommended by NCCLS.

Microwave-Assisted Synthesis of Chiral Oxime Ethers

2019 ◽  
Vol 16 (6) ◽  
pp. 495-500
Author(s):  
Asma Mehrez ◽  
Dalila Mtat ◽  
Ridha Touati
Keyword(s):  
Reaction Time ◽  
Microwave Irradiation ◽  
Sodium Hydride ◽  
Second Step ◽  
Chiral Amines ◽  
Microwave Assisted Synthesis ◽  
Ethyl Bromoacetate ◽  
Rapid Synthesis ◽  
New Class ◽  
Microwave Assisted

An efficient and rapid synthesis of a new class of chiral oxime ethers has been achieved via two-step reaction in which the first step is the reaction of oximes 1a-f with ethyl bromoacetate in the presence of sodium hydride to give oxime ethers 2a-f which are subsequently, in the second step, reacted with different commercially available chiral amines under microwave irradiation conditions to give compounds 3a-l in good to excellent yields. Through this method, we have observed a decrease in reaction time and excellent yields than the previously described conventional method.

Microwave-assisted dry-gel conversion-a new sustainable route for the rapid synthesis of metal–organic frameworks with solvent re-use

2018 ◽  
Vol 47 (29) ◽  
pp. 9850-9860 ◽  
Author(s):  
Niels Tannert ◽  
Serkan Gökpinar ◽  
Emrah Hastürk ◽  
Sandra Nießing ◽  
Christoph Janiak
Keyword(s):  
Microwave Irradiation ◽  
Metal Organic Frameworks ◽  
Rapid Synthesis ◽  
Fast Heating ◽  
Dry Gel Conversion ◽  
Microwave Assisted ◽  
Metal Organic

Microwave-assisted dry-gel conversion (MW-DGC) combines the advantages of concentrated reactants in DGC with fast heating by microwave irradiation.

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