scholarly journals A facile microwave-assisted protocol for rapid synthesis of N-acetylneuraminic acid congeners

2014 ◽  
Vol 38 (2) ◽  
pp. 507-510 ◽  
Author(s):  
Jonel P. Saludes ◽  
Dhananjaya Sahoo ◽  
I. Abrrey Monreal
Keyword(s):  
Microwave Irradiation ◽  
Rapid Synthesis ◽  
Acetylneuraminic Acid ◽  
Microwave Assisted

Microwave irradiation offers expedient access to important Neu5ac derivatives at rates that are 1- to 2-orders of magnitude faster than conventional techniques.

Microwave-assisted, palladium-catalyzed carbonylative cyclization — Rapid synthesis of 2-quinolones from unprotected 2-iodoanilines and terminal alkynes

2010 ◽  
Vol 88 (4) ◽  
pp. 331-337 ◽  
Author(s):  
Jia-Rong Chen ◽  
Jie Liao ◽  
Wen-Jing Xiao
Keyword(s):  
Carbon Monoxide ◽  
Microwave Irradiation ◽  
Molybdenum Hexacarbonyl ◽  
Terminal Alkynes ◽  
Solid Carbon ◽  
Rapid Synthesis ◽  
Microwave Assisted ◽  
Palladium Catalyzed ◽  
Quinolone Derivatives

Palladium-catalyzed cyclocarbonylations of 2-iodoanilines with various terminal alkynes have been carried out by the use of commercially available molybdenum hexacarbonyl as a convenient and solid carbon monoxide source. The reactions were conducted at 160 °C for 30 min under microwave irradiation and in the presence of Et3N in THF, affording the corresponding 2-quinolone derivatives in good regioselectivities and yields.

Microwave Assisted Synthesis of Isoquercitrin Using Enzymatic Hydrolysis of Rutin

2014 ◽  
Vol 1033-1034 ◽  
pp. 311-314 ◽  
Author(s):  
Jun Wang ◽  
Guo Xia Sun ◽  
An Gong ◽  
Xiang Yang Wu
Keyword(s):  
Reaction Time ◽  
Enzymatic Hydrolysis ◽  
Microwave Irradiation ◽  
Microwave Assisted Synthesis ◽  
Rapid Synthesis ◽  
Reaction Efficiency ◽  
Microwave Assisted ◽  
Hydrolysis Of

A novel and rapid synthesis of isoquercitrin using enzymatic hydrolysis of rutin under microwave irradiation was investigated. In the [Bmim][BF4]-buffer (pH 9.0) system under microwave irradiation, rutin conversion, isoquercitrin yield and quercetin yield were 89.18%, 84.74% and 2.79%, respectively, in conditions of 5 min and 30 °C. The preparation cost of isoquercitrin was significantly reduced by decreasing reaction time (from 10 h to 5 min) and increasing reaction efficiency (by 120 times).

scholarly journals Microwave-assisted rapid synthesis of a polyether from a plant oil derived monomer and its optimization by Box–Behnken design

RSC Advances ◽  
2017 ◽  
Vol 7 (45) ◽  
pp. 27946-27959 ◽  
Author(s):  
Reza Ahmadi ◽  
Aman Ullah
Keyword(s):  
Microwave Irradiation ◽  
Conventional Method ◽  
Plant Oil ◽  
Rapid Synthesis ◽  
Box Behnken Design ◽  
Microwave Assisted ◽  
New Strategy

In this study, a new strategy for making biopolyethers from plant oil derived monomer (α-olefin) was developed using microwave irradiation, conditions were optimized and compared with a conventional method.

Microwave-assisted rapid synthesis of sugar-based pyrazole derivatives with anticancer activity in water

RSC Advances ◽  
2016 ◽  
Vol 6 (71) ◽  
pp. 66803-66806 ◽  
Author(s):  
Kui Du ◽  
Chengcai Xia ◽  
Mengyi Wei ◽  
Xinzhi Chen ◽  
Pengfei Zhang
Keyword(s):  
Microwave Irradiation ◽  
Anticancer Activity ◽  
Pyrazole Derivatives ◽  
Rapid Synthesis ◽  
Green Method ◽  
Microwave Assisted

A rapid, efficient and green method has been developed for the synthesis of some novel sugar-based pyrazole derivatives in eco-friendly water under microwave irradiation in good yields.

Microwave-Assisted Synthesis of Chiral Oxime Ethers

2019 ◽  
Vol 16 (6) ◽  
pp. 495-500
Author(s):  
Asma Mehrez ◽  
Dalila Mtat ◽  
Ridha Touati
Keyword(s):  
Reaction Time ◽  
Microwave Irradiation ◽  
Sodium Hydride ◽  
Second Step ◽  
Chiral Amines ◽  
Microwave Assisted Synthesis ◽  
Ethyl Bromoacetate ◽  
Rapid Synthesis ◽  
New Class ◽  
Microwave Assisted

An efficient and rapid synthesis of a new class of chiral oxime ethers has been achieved via two-step reaction in which the first step is the reaction of oximes 1a-f with ethyl bromoacetate in the presence of sodium hydride to give oxime ethers 2a-f which are subsequently, in the second step, reacted with different commercially available chiral amines under microwave irradiation conditions to give compounds 3a-l in good to excellent yields. Through this method, we have observed a decrease in reaction time and excellent yields than the previously described conventional method.

Microwave-assisted dry-gel conversion-a new sustainable route for the rapid synthesis of metal–organic frameworks with solvent re-use

2018 ◽  
Vol 47 (29) ◽  
pp. 9850-9860 ◽  
Author(s):  
Niels Tannert ◽  
Serkan Gökpinar ◽  
Emrah Hastürk ◽  
Sandra Nießing ◽  
Christoph Janiak
Keyword(s):  
Microwave Irradiation ◽  
Metal Organic Frameworks ◽  
Rapid Synthesis ◽  
Fast Heating ◽  
Dry Gel Conversion ◽  
Microwave Assisted ◽  
Metal Organic

Microwave-assisted dry-gel conversion (MW-DGC) combines the advantages of concentrated reactants in DGC with fast heating by microwave irradiation.

Rapid Synthesis of Mesoporous Nickel Phosphates under Microwave Assisted Hydrothermal Condition

2012 ◽  
Vol 27 (5) ◽  
pp. 501-506
Author(s):  
Xu-Ying LI ◽  
Juan TAN ◽  
Jian-Hua YANG ◽  
Jing LIU ◽  
Fei YANG
Keyword(s):  
Hydrothermal Condition ◽  
Rapid Synthesis ◽  
Microwave Assisted ◽  
Nickel Phosphates

Regioselective Synthesis of Potent 4,5,6,7-Tetrahydroindazole Derivatives via Microwave-assisted Vilsmeier-Haack Reaction and their Antioxidant Activity Evaluation

2019 ◽  
Vol 16 (3) ◽  
pp. 194-201 ◽  
Author(s):  
Renu Bala ◽  
Vandana Devi ◽  
Pratibha Singh ◽  
Navjot Kaur ◽  
Pawandeep Kaur ◽  
...  
Keyword(s):  
Antioxidant Activity ◽  
Microwave Irradiation ◽  
Biological Activities ◽  
Reaction Times ◽  
Conventional Heating ◽  
High Chemical ◽  
Microwave Assisted ◽  
Work Up ◽  
Active Methylene ◽  
By Products

Background: Tetrahydroindazole, a member of the fused-pyrazole system, is a least studied class of heterocyclic compounds owing to its scarcity in nature. However, a large number of synthetically prepared tetrahydroindazoles are known to show a variety of biological activities such as interleukin- 2 inducible T-Cell kinase inhibitors, AMPA receptor positive allosteric modulators, antitumor, antituberculosis, anti-inflammatory and antimicrobial activities. Vilsmeier-Haack reaction is one of the most important chemical reactions used for formylation of electron rich arenes. Even though Vilsmeier- Haack reaction was studied on a wide variety of hydrazones derived from active methylene compounds, literature lacks the examples of the use of 4-substituted cyclohexanones as a substrate for the synthesis of 4,5,6,7-tetrahydroindazoles. The study of the reaction of Vilsmeier-Haack reagent with hydrazones derived from cyclic keto compounds having active methylene has been considered the interested topic of investigation. In the present study, ethyl cyclohexanone-4-carboxylate was treated with one equivalent of various hydrazines for two hours and the resulted hydrazones were further treated with an OPC-VH reagent (Vilsmeier-Haack reagent isolated from phthaloyl dichloride and N,Ndimethylformamide) afforded 4,5,6,7-tetrahydroindazoles in excellent yields. The synthesized compounds 4a-f and 5a-f were screened for their antioxidant activities using the DPPH radical scavenging assay. The target compounds were synthesized regioselectively using 4+1 approach in excellent yields. A number of experiments using both conventional heating as well as microwave irradiation methods were tried and on comparison, microwave irradiation method was found excellent in terms of easy work up, high chemical yields, shortened reaction times, clean and, no by-products formation. Some of the synthesized compounds showed significant antioxidant activity. The microwave assisted synthesis of 4,5,6,7-tetrahydroindazoles from ethyl cyclohexanone-4-carboxylate has been reported under mild conditions in excellent yield. Easy work up, high chemical yield, shortened reaction times, clean and no by-products formation are the major advantages of this protocol. These advantages may make this method useful for chemists who are interested in developing novel 4,5,6,7-tetrahydroindazole based drugs.

Sign in / Sign up

Export Citation Format

Share Document