Gold nanoparticles coated with a polydopamine layer and dextran brush surface for diagnosis and highly efficient photothermal therapy of tumors

RSC Advances ◽  
2016 ◽  
Vol 6 (39) ◽  
pp. 33083-33091 ◽  
Author(s):  
Chunyang Li ◽  
Zhijia Liu ◽  
Ping Yao
Keyword(s):  
Gold Nanoparticles ◽  
Laser Irradiation ◽  
Photothermal Therapy ◽  
Ct Imaging ◽  
Highly Efficient ◽  
Nir Laser

The nanoparticles improved tumor CT imaging and cured tumors after injection of the nanoparticles followed by NIR laser irradiation.

Concurrent photothermal therapy and photodynamic therapy for cutaneous squamous cell carcinoma by gold nanoclusters under a single NIR laser irradiation

2019 ◽  
Vol 7 (44) ◽  
pp. 6924-6933 ◽  
Author(s):  
Pei Liu ◽  
Weitao Yang ◽  
Lei Shi ◽  
Haiyan Zhang ◽  
Yan Xu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Photodynamic Therapy ◽  
Cell Carcinoma ◽  
Laser Irradiation ◽  
Squamous Cell ◽  
Photothermal Therapy ◽  
Gold Nanoclusters ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Single Drug ◽  
Nir Laser

The concurrent photothermal and photodynamic therapy of cutaneous squamous cell carcinoma by a single drug of Au25(Capt)18 nanoclusters is demonstrated, together with a preliminary immune response study conducted under a single NIR laser irradiation.

Preparation and in vitro evaluation of doxorubicin loaded alendronate modified hollow gold nanoparticles for bone-targeted chemo-photothermal therapy

2020 ◽  
Vol 10 (11) ◽  
pp. 1950-1959
Author(s):  
Lei Yang ◽  
Yumin Hu ◽  
Yuanfen Liu ◽  
Yanyan Liu ◽  
Si Miao ◽  
...  
Keyword(s):  
Gold Nanoparticles ◽  
Laser Irradiation ◽  
Photothermal Therapy ◽  
Bone Tumors ◽  
Drug Loading ◽  
Photothermal Effect ◽  
Osteosarcoma Cells ◽  
Hollow Gold Nanoparticles ◽  
Human Osteosarcoma Cells

The treatment of malignant bone tumors (including primary bone tumors and metastatic bone tumors) has always been a clinical challenge. The purpose of this study is to design a bone-targeted nano-carrier with photothermal effect to achieve chemo-photothermal therapy (CPT), which allows the minimal use of photothermal agents and chemical drugs to target bone tumors. Alendronate modified hollow gold nanoparticles (HGNPs- ALN) were synthesized using mercapto polyethylene glycol carboxyl (SH-PEG2000-COOH) as the connecting arm, fourier transform infrared spectroscopy (FTIR) and transmission electron microscopy (TEM) data show that HGNPs-ALN with a particle size of about 80 nm has been successfully synthesized. The hydroxyapatite affinity experiment in vitro indicated that HGNPs-ALN exhibited a high affinity to bone. In addition, the temperature of HGNPs-ALN under near-infrared laser irradiation can rise to 53 °C, which can achieve effective photothermal therapy for bone tumors. Bone-targeted hollow gold nanoparticles (DOX@HGNPs-ALN) loaded with doxorubicin hydrochloride (DOX) were synthesized by one-pot method. By comparing the stability and drug loading of HGNPs-ALN, it was concluded that the optimal mass ratio of HGNPs-ALN (calculated by the amount of gold) to DOX was about 1:2. HGNPs-ALN and DOX@HGNPs-ALN both have good photothermal stability and photothermal transformation properties, and confirmed the safety of HGNPs on human osteosarcoma cells. MTT experiments showed that DOX@HGNPs-ALN had the strongest killing effect on MG-63 osteosarcoma cells under laser irradiation (the killing rate is about 65%). According to these results, it can be considered that DOX@HGNPs-ALN has the potential of CPT synergistic targeting therapy for bone tumors.

scholarly journals Effects of macrophage polarization on gold nanoparticle-assisted plasmonic photothermal therapy

RSC Advances ◽  
2021 ◽  
Vol 11 (40) ◽  
pp. 25047-25056
Author(s):  
Hala R. Ali ◽  
Salah A. Selim ◽  
Daniel Aili
Keyword(s):  
Gold Nanoparticles ◽  
Laser Irradiation ◽  
Gold Nanoparticle ◽  
Photothermal Therapy ◽  
Macrophage Polarization ◽  
Preferential Uptake ◽  
M2 Phenotype ◽  
Plasmonic Photothermal Therapy

A preferential uptake of gold nanoparticles by macrophages with a protumoral M2 phenotype result in efficient killing upon laser irradiation while keeping M1 phenotypes relatively undamaged.

Multifunctional Bismuth Nanoparticles as Theranostic Agent for PA/CT Imaging and NIR Laser-Driven Photothermal Therapy

2018 ◽  
Vol 1 (2) ◽  
pp. 820-830 ◽  
Author(s):  
Chunyu Yang ◽  
Chongshen Guo ◽  
Wei Guo ◽  
Xiaole Zhao ◽  
Shaoqin Liu ◽  
...  
Keyword(s):  
Photothermal Therapy ◽  
Ct Imaging ◽  
Bismuth Nanoparticles ◽  
Theranostic Agent ◽  
Nir Laser

AgBiS2-TPP nanocomposite for mitochondrial targeting photodynamic therapy, photothermal therapy and bio-imaging under 808 nm NIR laser irradiation

2019 ◽  
Vol 7 (11) ◽  
pp. 4769-4781 ◽  
Author(s):  
Mingdi Sun ◽  
Dan Yang ◽  
Chen Wang ◽  
Huiting Bi ◽  
Yuan Zhou ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Laser Irradiation ◽  
Photothermal Therapy ◽  
Mitochondrial Targeting ◽  
Nir Light ◽  
Bio Imaging ◽  
First Time ◽  
Nir Laser

AgBiS2 nanodots as an NIR light-excited photosensitizer produce a PDT effect, which is reported for the first time.

scholarly journals Escherichia coli adhesin protein-conjugated thermal responsive hybrid nanoparticles for photothermal and immunotherapy against cancer and its metastasis

2021 ◽  
Vol 9 (7) ◽  
pp. e002666
Author(s):  
Juyoung Hwang ◽  
Wei Zhang ◽  
Hae-Bin Park ◽  
Dhananjay Yadav ◽  
Yong Hyun Jeon ◽  
...  
Keyword(s):  
Laser Irradiation ◽  
Photothermal Therapy ◽  
Near Infrared ◽  
High Efficiency ◽  
Hybrid Nanoparticles ◽  
Therapeutic Effects ◽  
Primary Tumors ◽  
Hybrid Nanoparticle ◽  
Nir Laser

BackgroundAdvanced cancer therapy is targeted at primary tumors and also recurrent or metastatic cancers. Combinational cancer treatment has recently shown high efficiency against recurrent and metastatic cancers. In this study, we synthesized a thermal responsive hybrid nanoparticle (TRH) containing FimH, an immune stimulatory recombinant protein, for the induction of a combination of photothermal therapy (PTT) and immunotherapy against cancer and its metastasis.MethodsThe hybrid nanoparticle was incorporated with a near-infrared (NIR) absorbent, indocyanine green, and decorated with FimH on its surface to form F-TRH. F-TRH was evaluated for its anticancer and antimetastatic effects against CT-26 carcinoma in mice by combining PTT and immunotherapy.ResultsNIR laser irradiation elicited an elevation of temperature in F-TRH, which induced apoptosis in CT-26 carcinoma cells in vitro. In addition, F-TRH and NIR laser irradiation promoted photothermal-mediated therapeutic effects against CT-26 and 4T1 tumors in mice. The release of FimH from F-TRH in response to elevated temperature and apoptotic bodies of cancer cells via PTT elicited dendritic cell-mediated cancer antigen-specific T-cell responses, which subsequently inhibited the second challenge of CT-26 and 4T1 cell growth in the lung.ConclusionsThese data demonstrate the potential use of F-TRH for immuno-photothermal therapy against cancer and its recurrence and metastasis.

scholarly journals Multifunctional theranostic gold nanoparticles for targeted CT imaging and photothermal therapy

2014 ◽  
Vol 9 (1) ◽  
pp. 53-61 ◽  
Author(s):  
Taeyjuana Curry ◽  
Raoul Kopelman ◽  
Malka Shilo ◽  
Rachela Popovtzer
Keyword(s):  
Gold Nanoparticles ◽  
Photothermal Therapy ◽  
Ct Imaging

Gd3+-Doped MoSe2 nanosheets used as a theranostic agent for bimodal imaging and highly efficient photothermal cancer therapy

2018 ◽  
Vol 6 (2) ◽  
pp. 372-387 ◽  
Author(s):  
Jiali Pan ◽  
Xufeng Zhu ◽  
Xu Chen ◽  
Yingyu Zhao ◽  
Jie Liu
Keyword(s):  
Cancer Therapy ◽  
Laser Irradiation ◽  
High Stability ◽  
Photothermal Effect ◽  
Highly Efficient ◽  
Theranostic Agent ◽  
Bimodal Imaging ◽  
Low Toxicity ◽  
Nir Laser

MoSe2(Gd3+)-PEG nanosheets with high stability and low toxicity used to achieve a MR/PA bimodal imaging monitoring super photothermal effect under NIR laser irradiation.

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