scholarly journals Macrolactam analogues of macrolide natural products

2016 ◽  
Vol 14 (48) ◽  
pp. 11301-11316 ◽  
Author(s):  
Helmut M. Hügel ◽  
Andrew T. Smith ◽  
Mark A. Rizzacasa
Keyword(s):  
Natural Products ◽  
Biological Activity ◽  
Chemical Modification ◽  
Metabolic Stability

The chemical modification of macrolide natural products into aza- or lactam analogues is a strategy employed to improve their metabolic stability and biological activity.

Natural Products of the Fungal Genus Humicola: Diversity, Biological Activity, and Industrial Importance

2021 ◽  
Author(s):  
Sabrin R. M. Ibrahim ◽  
Shaimaa G. A. Mohamed ◽  
Ahmed E. Altyar ◽  
Gamal A. Mohamed
Keyword(s):  
Natural Products ◽  
Biological Activity ◽  
Fungal Genus

scholarly journals Antinociceptive, Anti-Inflammatory, and Antipyretic Activity of Mangrove Plants: A Mini Review

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
J. A. Shilpi ◽  
M. E. Islam ◽  
M. Billah ◽  
K. M. D. Islam ◽  
F. Sabrin ◽  
...  
Keyword(s):  
Natural Products ◽  
Biological Activity ◽  
Plant Species ◽  
Active Compound ◽  
Medicinal Uses ◽  
Antipyretic Activity ◽  
Mangrove Plants ◽  
The World ◽  
Anti Inflammatory ◽  
The Web

Mangrove plants are specialised plants that grow in the tidal coasts of tropic and subtropic regions of the world. Their unique ecology and traditional medicinal uses of mangrove plants have attracted the attention of researchers over the years, and as a result, reports on biological activity of mangrove plants have increased significantly in recent years. This review has been set out to compile and appraise the results on antinociceptive, anti-inflammatory, and antipyretic activity of mangrove plants. While the Web of Knowledge, Google Scholar, and PubMed were the starting points to gather information, other pieces of relevant published literature were also adequately explored for this purpose. A total of 29 reports on 17 plant species have been found to report such activities. While 19 reports were on the biological activity of the crude extracts, 10 reports identified the active compound(s) of various chemical classes of natural products including terpenes, steroids, and flavonoids. This review finds that antinociceptive, anti-inflammatory, and antipyretic activity appears to be widespread in mangrove plants.

scholarly journals Directed aromatic functionalization in natural-product synthesis: Fredericamycin A, nothapodytine B, and topopyrones B and D

2011 ◽  
Vol 7 ◽  
pp. 1475-1485 ◽  
Author(s):  
Charles Dylan Turner ◽  
Marco A Ciufolini
Keyword(s):  
Natural Products ◽  
Biological Activity ◽  
Natural Product ◽  
Natural Product Synthesis ◽  
Fredericamycin A

This is a review of our efforts toward the synthesis of a group of natural products that display noteworthy biological activity: Fredericamycin A, nothapodytine B, and topopyrones B and D. In each case, directed aromatic functionalization methodology greatly facilitated the assembly of the key molecular subunits.

The effect on fungal growth of some 2,5-dihydroxy-1,4-benzoquinones

1977 ◽  
Vol 23 (7) ◽  
pp. 845-851 ◽  
Author(s):  
D. Brewer ◽  
W. S. G. Maass ◽  
A. Taylor
Keyword(s):  
Biological Activity ◽  
Chemical Modification ◽  
Spore Germination ◽  
Vegetative Growth ◽  
Fungal Growth ◽  
Hydroxyl Groups ◽  
Growth Inhibitory ◽  
Inhibit Spore Germination

It has been shown that 2,5-dihydroxy-1,4-benzoquinones decrease vegetative growth and inhibit spore germination of 12 species of fungi belonging to six diverse genera. The nature of the substituents at the 3 and 6 positions of the quinone ring also affected their growth-inhibitory properties; generally those substituents of lower polarity inhibited growth at lower concentrations. As in the case of cochliodinol, chemical modification of the quinone group, or the hydroxyl groups of the quinone ring, in compounds of the polyporic acid series, also led to loss of biological activity.

Chemical and Functional Diversity of Natural Products from Plant Associated Endophytic Fungi

2009 ◽  
Vol 4 (11) ◽  
pp. 1934578X0900401 ◽  
Author(s):  
Vijay C. Verma ◽  
Ravindra N. Kharwar ◽  
Gary A. Strobel
Keyword(s):  
Natural Products ◽  
Biological Activity ◽  
Functional Diversity ◽  
Bioactive Compounds ◽  
Endophytic Fungi ◽  
Host Plants ◽  
Fungal Endophytes ◽  
Sources Identification ◽  
Naturally Occurring

This review describes examples of naturally occurring bioactive compounds obtained from fungal endophytes from various host plants. The main topics addressed are sources, identification, biological activity, biosynthesis, and ecological and chemosystematic significance of those bioactive compounds whose sources were well defined.

Inhibitors of cytosolic phospholipase A2α with carbamate structure: synthesis, biological activity, metabolic stability, and bioavailability

2014 ◽  
Vol 23 (12) ◽  
pp. 5250-5262 ◽  
Author(s):  
Julian Schwarzkopf ◽  
Tom Sundermann ◽  
Martina Arnsmann ◽  
Walburga Hanekamp ◽  
Jörg Fabian ◽  
...  
Keyword(s):  
Biological Activity ◽  
Metabolic Stability ◽  
Cytosolic Phospholipase ◽  
Structure Synthesis ◽  
Cytosolic Phospholipase A2α
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