Bioconjugation – using selective chemistry to enhance the properties of proteins and peptides as therapeutics and carriers

2016 ◽  
Vol 14 (34) ◽  
pp. 8002-8013 ◽  
Author(s):  
Smita B. Gunnoo ◽  
Annemieke Madder
Keyword(s):  
Chemical Modification ◽  
Protein Therapeutics ◽  
Wide Range ◽  
Therapeutic Properties ◽  
Selective Chemical ◽  
Site Selective ◽  
Proteins And Peptides

Both peptide and protein therapeutics are becoming increasingly important for treating a wide range of diseases. Functionalisation of theseviasite-selective chemical modification leads to enhancement of their therapeutic properties.

nSite-Selective, Chemical Modification of Protein at Aromatic Side Chain and Their Emergent Applications

2021 ◽  
Vol 28 ◽  
Author(s):  
Arnab Chowdhury ◽  
Saurav Chatterjee ◽  
Akumlong Pongen ◽  
Dhanjit Sarania ◽  
Nitesh Mani Tripathi ◽  
...  
Keyword(s):  
Chemical Modification ◽  
Chemical Reactivity ◽  
Future Perspective ◽  
Side Chain ◽  
Aromatic Side Chain ◽  
Therapeutic Applications ◽  
Selective Chemical ◽  
Photocatalytic Reactions ◽  
Metal Catalyzed ◽  
Site Selective

: Site-selective chemical modification of protein side chain has probed enormous opportunities in the fundamental understanding of cellular biology and therapeutic applications. Primarily, in the field of biopharmaceutical where formulation of bioconjugates is found to be potential medicine than an individual constituent. In this regard, Lysine and Cysteine are the most widely used endogenous amino acid for these purposes. Recently, the aromatic side chain residues (Trp, Tyr, and His) that are low abundant in protein have gained more attention in therapeutic applications due to their advantages of chemical reactivity and specificity. This review discusses the site-selective bioconjugation methods for aromatic side chains (Trp, Tyr and His) and highlights the developed strategies in the last three years, along with their applications. Also, the review highlights the prevalent methods published earlier. We have examined that metal-catalyzed and photocatalytic reactions are gaining more attention for bioconjugation, though their practical operation is under development. The review has been summarized with the future perspective of protein and peptide conjugations contemplating therapeutic applications and challenges.

Site-selective Chemical Modification of Chymotrypsin Using a Peptidyl Diphenyl 1-Amino-2-phenylethylphosphonate Derivative

2013 ◽  
Vol 42 (8) ◽  
pp. 860-862 ◽  
Author(s):  
Shin Ono ◽  
Junya Murai ◽  
Takahiko Nakai ◽  
Hirofumi Kuroda ◽  
Yoshikazu Horino ◽  
...  
Keyword(s):  
Chemical Modification ◽  
Selective Chemical ◽  
Site Selective

Recognition Directed Site-Selective Chemical Modification of Molecularly Imprinted Polymers

2001 ◽  
Vol 34 (24) ◽  
pp. 8446-8452 ◽  
Author(s):  
Robert J. Umpleby ◽  
Gregory T. Rushton ◽  
Ripal N. Shah ◽  
Andrew M. Rampey ◽  
Jessica C. Bradshaw ◽  
...  
Keyword(s):  
Chemical Modification ◽  
Molecularly Imprinted Polymers ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Selective Chemical ◽  
Site Selective

Chinese Medicine Protein and Peptide in Gene and Cell Therapy

2019 ◽  
Vol 20 (3) ◽  
pp. 251-264 ◽  
Author(s):  
Yinlu Feng ◽  
Zifei Yin ◽  
Daniel Zhang ◽  
Arun Srivastava ◽  
Chen Ling
Keyword(s):  
Chinese Medicine ◽  
Cell Therapy ◽  
Future Research ◽  
The Past ◽  
Promising Strategy ◽  
Wide Range ◽  
New Directions ◽  
Gene And Cell Therapy ◽  
Proteins And Peptides

The success of gene and cell therapy in clinic during the past two decades as well as our expanding ability to manipulate these biomaterials are leading to new therapeutic options for a wide range of inherited and acquired diseases. Combining conventional therapies with this emerging field is a promising strategy to treat those previously-thought untreatable diseases. Traditional Chinese medicine (TCM) has evolved for thousands of years in China and still plays an important role in human health. As part of the active ingredients of TCM, proteins and peptides have attracted long-term enthusiasm of researchers. More recently, they have been utilized in gene and cell therapy, resulting in promising novel strategies to treat both cancer and non-cancer diseases. This manuscript presents a critical review on this field, accompanied with perspectives on the challenges and new directions for future research in this emerging frontier.

scholarly journals Rational Generation of Lasso Peptides Based on Biosynthetic Gene Mutations and Site-Selective Chemical Modifications

2021 ◽  
Author(s):  
Tan Liu ◽  
Xiaojie Ma ◽  
Jiahui Yu ◽  
Wensheng Yang ◽  
guiyang wang ◽  
...  
Keyword(s):  
Natural Products ◽  
Gene Mutations ◽  
Proteolytic Degradation ◽  
Biosynthetic Gene ◽  
Chemical Modifications ◽  
Lasso Peptides ◽  
Selective Chemical ◽  
Site Selective

Lasso peptides are a unique family of natural products whose structures feature a specific threaded fold, which confers these peptides the resistance to thermal and proteolytic degradation. This stability gives...

scholarly journals Enamine/Transition Metal Combined Catalysis: Catalytic Transformations Involving Organometallic Electrophilic Intermediates

2019 ◽  
Vol 377 (6) ◽  
Author(s):  
Samson Afewerki ◽  
Armando Córdova
Keyword(s):  
Transition Metal ◽  
Metal Complex ◽  
Carbonyl Compounds ◽  
Transition Metal Catalysis ◽  
Chemical Transformations ◽  
Considerable Effort ◽  
Metal Catalysis ◽  
First Report ◽  
Wide Range ◽  
Selective Chemical

AbstractThe concept of merging enamine activation catalysis with transition metal catalysis is an important strategy, which allows for selective chemical transformations not accessible without this combination. The amine catalyst activates the carbonyl compounds through the formation of a reactive nucleophilic enamine intermediate and, in parallel, the transition metal activates a wide range of functionalities such as allylic substrates through the formation of reactive electrophilic π-allyl-metal complex. Since the first report of this strategy in 2006, considerable effort has been devoted to the successful advancement of this technology. In this chapter, these findings are highlighted and discussed.

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