Site-selective chemical modification of chymotrypsin using peptidyl derivatives bearing optically active diphenyl 1-amino-2-phenylethylphosphonate: Stereochemical effect of the diphenyl phosphonate moiety

Biopolymers ◽  
2016 ◽  
Vol 106 (4) ◽  
pp. 521-530 ◽  
Author(s):  
Shin Ono ◽  
Takahiko Nakai ◽  
Hirofumi Kuroda ◽  
Ryuta Miyatake ◽  
Yoshikazu Horino ◽  
...  
Keyword(s):  
Chemical Modification ◽  
Optically Active ◽  
Selective Chemical ◽  
Site Selective

nSite-Selective, Chemical Modification of Protein at Aromatic Side Chain and Their Emergent Applications

2021 ◽  
Vol 28 ◽  
Author(s):  
Arnab Chowdhury ◽  
Saurav Chatterjee ◽  
Akumlong Pongen ◽  
Dhanjit Sarania ◽  
Nitesh Mani Tripathi ◽  
...  
Keyword(s):  
Chemical Modification ◽  
Chemical Reactivity ◽  
Future Perspective ◽  
Side Chain ◽  
Aromatic Side Chain ◽  
Therapeutic Applications ◽  
Selective Chemical ◽  
Photocatalytic Reactions ◽  
Metal Catalyzed ◽  
Site Selective

: Site-selective chemical modification of protein side chain has probed enormous opportunities in the fundamental understanding of cellular biology and therapeutic applications. Primarily, in the field of biopharmaceutical where formulation of bioconjugates is found to be potential medicine than an individual constituent. In this regard, Lysine and Cysteine are the most widely used endogenous amino acid for these purposes. Recently, the aromatic side chain residues (Trp, Tyr, and His) that are low abundant in protein have gained more attention in therapeutic applications due to their advantages of chemical reactivity and specificity. This review discusses the site-selective bioconjugation methods for aromatic side chains (Trp, Tyr and His) and highlights the developed strategies in the last three years, along with their applications. Also, the review highlights the prevalent methods published earlier. We have examined that metal-catalyzed and photocatalytic reactions are gaining more attention for bioconjugation, though their practical operation is under development. The review has been summarized with the future perspective of protein and peptide conjugations contemplating therapeutic applications and challenges.

Site-selective Chemical Modification of Chymotrypsin Using a Peptidyl Diphenyl 1-Amino-2-phenylethylphosphonate Derivative

2013 ◽  
Vol 42 (8) ◽  
pp. 860-862 ◽  
Author(s):  
Shin Ono ◽  
Junya Murai ◽  
Takahiko Nakai ◽  
Hirofumi Kuroda ◽  
Yoshikazu Horino ◽  
...  
Keyword(s):  
Chemical Modification ◽  
Selective Chemical ◽  
Site Selective

Bioconjugation – using selective chemistry to enhance the properties of proteins and peptides as therapeutics and carriers

2016 ◽  
Vol 14 (34) ◽  
pp. 8002-8013 ◽  
Author(s):  
Smita B. Gunnoo ◽  
Annemieke Madder
Keyword(s):  
Chemical Modification ◽  
Protein Therapeutics ◽  
Wide Range ◽  
Therapeutic Properties ◽  
Selective Chemical ◽  
Site Selective ◽  
Proteins And Peptides

Both peptide and protein therapeutics are becoming increasingly important for treating a wide range of diseases. Functionalisation of theseviasite-selective chemical modification leads to enhancement of their therapeutic properties.

Recognition Directed Site-Selective Chemical Modification of Molecularly Imprinted Polymers

2001 ◽  
Vol 34 (24) ◽  
pp. 8446-8452 ◽  
Author(s):  
Robert J. Umpleby ◽  
Gregory T. Rushton ◽  
Ripal N. Shah ◽  
Andrew M. Rampey ◽  
Jessica C. Bradshaw ◽  
...  
Keyword(s):  
Chemical Modification ◽  
Molecularly Imprinted Polymers ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Selective Chemical ◽  
Site Selective

scholarly journals Rational Generation of Lasso Peptides Based on Biosynthetic Gene Mutations and Site-Selective Chemical Modifications

2021 ◽  
Author(s):  
Tan Liu ◽  
Xiaojie Ma ◽  
Jiahui Yu ◽  
Wensheng Yang ◽  
guiyang wang ◽  
...  
Keyword(s):  
Natural Products ◽  
Gene Mutations ◽  
Proteolytic Degradation ◽  
Biosynthetic Gene ◽  
Chemical Modifications ◽  
Lasso Peptides ◽  
Selective Chemical ◽  
Site Selective

Lasso peptides are a unique family of natural products whose structures feature a specific threaded fold, which confers these peptides the resistance to thermal and proteolytic degradation. This stability gives...

Site-Selective Protein Chemical Modification of Exposed Tyrosine Residues Using Tyrosine Click Reaction

2020 ◽  
Vol 31 (5) ◽  
pp. 1417-1424 ◽  
Author(s):  
Shinichi Sato ◽  
Masaki Matsumura ◽  
Tetsuya Kadonosono ◽  
Satoshi Abe ◽  
Takafumi Ueno ◽  
...  
Keyword(s):  
Chemical Modification ◽  
Click Reaction ◽  
Tyrosine Residues ◽  
Site Selective
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