scholarly journals Diamond nanostructures for drug delivery, bioimaging, and biosensing

2017 ◽  
Vol 46 (3) ◽  
pp. 734-760 ◽  
Author(s):  
Xianfeng Chen ◽  
Wenjun Zhang
Keyword(s):  
Drug Delivery ◽  
Diamond Nanoparticles ◽  
Vertically Aligned

This review summarizes the superior properties of diamond nanoparticles and vertically aligned diamond nanoneedles and their applications in biosensing, bioimaging and drug delivery.

Diamond nanoparticles for image-guided drug delivery application

2017 ◽  
Vol 256 ◽  
pp. S93-S94
Author(s):  
Yu Chung Lin ◽  
Zhe Rui Lin ◽  
Chia Chi Chang ◽  
Elena Perevedentseva ◽  
Chia Liang Cheng
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Application ◽  
Diamond Nanoparticles ◽  
Image Guided ◽  
Image Guided Drug Delivery

scholarly journals Feasibility Study of Carbon Nanotube Microneedles for Rapid Transdermal Drug Delivery

2013 ◽  
Vol 1569 ◽  
pp. 239-244 ◽  
Author(s):  
Bradley J. Lyon ◽  
Adrianus I. Aria ◽  
Morteza Gharib
Keyword(s):  
Drug Delivery ◽  
Transdermal Drug Delivery ◽  
High Strength ◽  
New Approach ◽  
Aligned Carbon Nanotubes ◽  
Vertically Aligned ◽  
Flow Through ◽  
Trade Study ◽  
Hollow Microneedles

ABSTRACTWe introduce a new approach for fabricating hollow microneedles using vertically-aligned carbon nanotubes (VA-CNTs) for rapid transdermal drug delivery. Here, we discuss the fabrication of the microneedles emphasizing the overall simplicity and flexibility of the method to allow for potential industrial application. By capitalizing on the nanoporosity of the CNT bundles, uncured polymer can be wicked into the needles ultimately creating a high strength composite of aligned nanotubes and polymer. Flow through the microneedles as well as in vitro penetration of the microneedles into swine skin is demonstrated. Furthermore, we present a trade study comparing the difficulty and complexity of the fabrication process of our CNT-polymer microneedles with other standard microneedle fabrication approaches.

scholarly journals Synthesis of CVD Diamond nanoparticles and  Cytotoxicity evaluation in murine metastatic melanoma cells

2020 ◽  
Author(s):  
Cristiane Costa Wachesk ◽  
Carolina Guimarães Hurtado ◽  
Rebeca Falcão ◽  
Dayane Batista Tada ◽  
Getulio Vasconcelos ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Metastatic Melanoma ◽  
Natural Diamond ◽  
Cvd Diamond ◽  
Hydrodynamic Diameter ◽  
High Concentration ◽  
Diamond Nanoparticles ◽  
Delivery Platform ◽  
Potential Use

Abstract Diamond nanoparticles (DNPs) have showed in vitro and in vivo biomedical applicability due to their low toxicity and biocompatibility. Recent studies have focused on the potential use of (DNPs) as suitable vehicles for improving drug delivery in cancer treatment. The advantages of DNPs lies in their high stability and small size compared to other carbon-based nanomaterials. In this work, CVD-diamond nanoparticles (CVD-DNPs) were synthesized and evaluated regarding their application as a new drug delivery platform for metastatic melanoma therapy. A new synthesis technique developed DNPs from CVD diamond thin film. This type of diamond has the same physical and chemical properties as a natural diamond: extreme hardness, excellent thermal conductivity, low coefficient of friction, biocompatibility, chemically inert for temperatures below 800 0 C, among others. The main objective of this study was to produce CVD-DNPs by laser ablation and to evaluate their cytotoxicity. A pulsed, ytterbium-doped fiber (Yb) was used to form DNPs in the pure aqueous medium (Milli-Q). The final suspension was obtained at high concentration of the CVD-DNPs and it was used to evaluate the cytotxicity in murine metastatic melanoma B16-F10 cells by using colorimetric assays. The characterization by FT-IR, X-Ray, DLS, RAMAN, SEM, and TEM demonstrated the successful synthesis of CVD-DNPs with a hydrodynamic diameter of 57 and 54 nm. In vitr o studies performed for 24h and 48h resulted in viability of 70-80% of cells incubated with CVD-DNPs at 250 μg/mL, which demonstrated a insignificant cytotoxic effect. Thus, these results suggest a potential use of CVD-DNPs as a drug delivery platform for antitumoral therapy.

Control of electrostatic self-assembly seeding of diamond nanoparticles on carbon nanowalls

2021 ◽  
Vol 33 (10) ◽  
pp. 105605
Author(s):  
Lei Huang ◽  
Xiangqing Wu ◽  
Ryota Hijiya ◽  
Kungen Teii
Keyword(s):  
Self Assembly ◽  
Microwave Plasma ◽  
Chemical Vapor ◽  
Plasma Chemical Vapor Deposition ◽  
Diamond Nanoparticles ◽  
Mean Size ◽  
Zero Degree ◽  
Vertically Aligned ◽  
Carbon Nanowalls ◽  
Diamond Nanoparticle

Abstract Seeding of diamond nanoparticles on vertically-aligned multi-layer graphene, the so-called carbon nanowalls (CNWs), is studied by using deionized water, ethylene glycol, ethanol, and formamide as dispersion mediums. Detonation nanodiamond particles show the smallest mean size and size distribution with a high positive zeta potential when dispersed in ethanol. The contact angle of ethanol on CNWs is almost zero degree, confirming highly wetting behaviour. The diamond nanoparticles dispersed in ethanol are distributed the most uniformly with minimal aggregation on CNWs as opposed to those dispersed in other liquids. The resulting diamond nanoparticle-seeded CNWs, followed by short-term growth in microwave plasma chemical vapor deposition, show a marked decrease in field emission turn-on field down to 1.3 V μm−1 together with a large increase in current density, compared to bare CNWs without diamond seeding. The results provide a way to control the density, size, and uniformity (spacing) of diamond nanoparticles on CNWs and should be applied to fabricate hybrid materials and devices using nanodiamond and nanocarbons.

scholarly journals Functionalized diamond nanoparticles as a drug delivery system: Loading and release study

2019 ◽  
Vol 3 (1) ◽  
Author(s):  
Parvaneh Rouhani ◽  
Nirmal Govindaraju ◽  
Janaki K. Iyer ◽  
Rashmi Kaul ◽  
Anil Kaul ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Diamond Nanoparticles ◽  
Release Study

scholarly journals Loading Amlodipine on Diamond Nanoparticles: A Novel Drug Delivery System

2020 ◽  
Vol Volume 12 ◽  
pp. 47-53
Author(s):  
Shawqi H Alawdi ◽  
Housam Eidi ◽  
Marwa M Safar ◽  
Mosaad A Abdel-Wahhab
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Diamond Nanoparticles ◽  
System P ◽  
Novel Drug Delivery System ◽  
Novel Drug

Techniques For The Preparation of Tissue Samples Containing Injectable Polymer Microcapsules

1985 ◽  
Vol 43 ◽  
pp. 710-711
Author(s):  
G.E. Visscher ◽  
R. L. Robison ◽  
G. J. Argentieri
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Gastrocnemius Muscle ◽  
Degradation Process ◽  
Delivery Systems ◽  
Tissue Reaction ◽  
Electron Microscopic ◽  
Tissue Samples ◽  
Injectable Polymer ◽  
Microscopic Techniques

The use of various bioerodable polymers as drug delivery systems has gained considerable interest in recent years. Among some of the shapes used as delivery systems are films, rods and microcapsules. The work presented here will deal with the techniques we have utilized for the analysis of the tissue reaction to and actual biodegradation of injectable microcapsules. This work has utilized light microscopic (LM), transmission (TEM) and scanning (SEM) electron microscopic techniques. The design of our studies has utilized methodology that would; 1. best characterize the actual degradation process without artifacts introduced by fixation procedures and 2. allow for reproducible results.In our studies, the gastrocnemius muscle of the rat was chosen as the injection site. Prior to the injection of microcapsules the skin above the sites was shaved and tattooed for later recognition and recovery. 1.0 cc syringes were loaded with the desired quantity of microcapsules and the vehicle (0.5% hydroxypropylmethycellulose) drawn up. The syringes were agitated to suspend the microcapsules in the injection vehicle.

Nanotheranostic agents for neurodegenerative diseases

2020 ◽  
Vol 4 (6) ◽  
pp. 645-675
Author(s):  
Parasuraman Padmanabhan ◽  
Mathangi Palanivel ◽  
Ajay Kumar ◽  
Domokos Máthé ◽  
George K. Radda ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Neurodegenerative Diseases ◽  
Cell Types ◽  
Specific Cell ◽  
Ageing Population ◽  
Target Tissue ◽  
Therapeutic Approaches ◽  
Surface Receptors ◽  
Theranostic Agents ◽  
Preclinical Animal Models

Neurodegenerative diseases (NDDs), including Alzheimer's disease (AD) and Parkinson's disease (PD), affect the ageing population worldwide and while severely impairing the quality of life of millions, they also cause a massive economic burden to countries with progressively ageing populations. Parallel with the search for biomarkers for early detection and prediction, the pursuit for therapeutic approaches has become growingly intensive in recent years. Various prospective therapeutic approaches have been explored with an emphasis on early prevention and protection, including, but not limited to, gene therapy, stem cell therapy, immunotherapy and radiotherapy. Many pharmacological interventions have proved to be promising novel avenues, but successful applications are often hampered by the poor delivery of the therapeutics across the blood-brain-barrier (BBB). To overcome this challenge, nanoparticle (NP)-mediated drug delivery has been considered as a promising option, as NP-based drug delivery systems can be functionalized to target specific cell surface receptors and to achieve controlled and long-term release of therapeutics to the target tissue. The usefulness of NPs for loading and delivering of drugs has been extensively studied in the context of NDDs, and their biological efficacy has been demonstrated in numerous preclinical animal models. Efforts have also been made towards the development of NPs which can be used for targeting the BBB and various cell types in the brain. The main focus of this review is to briefly discuss the advantages of functionalized NPs as promising theranostic agents for the diagnosis and therapy of NDDs. We also summarize the results of diverse studies that specifically investigated the usage of different NPs for the treatment of NDDs, with a specific emphasis on AD and PD, and the associated pathophysiological changes. Finally, we offer perspectives on the existing challenges of using NPs as theranostic agents and possible futuristic approaches to improve them.

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