scholarly journals Functionalized diamond nanoparticles as a drug delivery system: Loading and release study

2019 ◽  
Vol 3 (1) ◽  
Author(s):  
Parvaneh Rouhani ◽  
Nirmal Govindaraju ◽  
Janaki K. Iyer ◽  
Rashmi Kaul ◽  
Anil Kaul ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Diamond Nanoparticles ◽  
Release Study

scholarly journals Loading Amlodipine on Diamond Nanoparticles: A Novel Drug Delivery System

2020 ◽  
Vol Volume 12 ◽  
pp. 47-53
Author(s):  
Shawqi H Alawdi ◽  
Housam Eidi ◽  
Marwa M Safar ◽  
Mosaad A Abdel-Wahhab
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Diamond Nanoparticles ◽  
System P ◽  
Novel Drug Delivery System ◽  
Novel Drug

Nanocapsulation of Nitazoxanide in Solid Lipid Nanoparticles as a New Drug Delivery System and in vitro Release Study

2016 ◽  
Vol 16 (4) ◽  
pp. 120-127 ◽  
Author(s):  
Roghayeh Abbasalipo ◽  
Mohammad Fallah ◽  
Fruzan Sedighi ◽  
Amir Hossein Maghsood ◽  
Saman Javid
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Solid Lipid Nanoparticles ◽  
In Vitro Release ◽  
Lipid Nanoparticles ◽  
Solid Lipid ◽  
Release Study ◽  
Vitro Release

scholarly journals Formulation and evaluation of transdermal drug delivery system of verapamil hydrochloride

2018 ◽  
Vol 8 (6-s) ◽  
pp. 70-77
Author(s):  
S C Marapur ◽  
D S Wali ◽  
B S Hunasagi ◽  
M Chetankumar ◽  
R G Patil
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Transdermal Drug Delivery ◽  
Skin Irritation ◽  
Solvent Evaporation ◽  
Transdermal Drug Delivery System ◽  
Verapamil Hydrochloride ◽  
Weight Variation ◽  
Release Study

The aim of this research was to develop and evaluate a matrix type of transdermal drug delivery system containing Verapamil Hydrochloride. The series of formulations containing Verapamil Hydrochloride were formulated by using different polymers like HPMC (hydrophilic), CAP (hydrophobic) and EC (hydrophobic) in different ratios by solvent evaporation technique. Propylene glycol and Dibutyl phthalate were used as plasticizers. The 20% and 40% of DMSO is used as the penetration enhancer. Formulated transdermal patches were physically evaluated for thickness, weight variation, drug content, flatness, tensile strength, folding endurance, and water vapour transmission rate. The in-vitro drug release study was carried out by using Franz diffusion cell. The data obtained from release study shows increased percentage of drug permeated in 20% of DMSO containing formulation than 40% of DMSO containing formulation. Drug permeation is enhanced in the formulation containing high concentration of HPMC (VH1). The VH2 and VH6 helped in maintaining the rate of release at a constant level (20% DMSO). But in case of 40% DMSO is used as the concentration of CAP increases the rate of permeation increases. Skin irritation study does not show any irritation on the skin of rabbit. There is no possible interaction between drug and polymers in FITR as well as DSC. XRD of selected formulation shows that drug present in the formulation is in crystalline form. Keywords: Verapamil HCl, HPMC, EC, CAP, DMSO, TDDS, Solvent evaporation

scholarly journals FORMULATION AND EVALUATION OF IMPLANTABLE DRUG DELIVERY SYSTEM OF TEMOZOLOMIDE BY USING HYDROPHILIC POLYMER

2017 ◽  
Vol 10 (11) ◽  
pp. 239
Author(s):  
Sindhu Vemula ◽  
Bhavya S ◽  
Suresh Kumar P ◽  
Jeyabaskaran M ◽  
Praveenkumar T ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
In Vitro Release ◽  
Hydrophilic Polymer ◽  
Short Term ◽  
Drug Content ◽  
Release Study ◽  
Vitro Release

  Objective: The present research study was carried out to formulate and evaluate the implants of temozolomide using hydrophilic polymer.Methods: Temozolomide implants were formulated using extrusion method with different grades of carbopol. The powdered blend was evaluated for micromeritic properties such as angle of repose, bulk density, tapped density, Carr’s index, and Hausner’s ratio. The formulated implants were analyzed for drug content uniformity, thickness, weight variation, and short-term stability study. In vitro release study of implants was performed using 0.1N hydrochloric acid, and it is maintained at 37°C±0.5°C.Results: In vitro release study demonstrated that the release rate of temozolomide from the implant matrix was a function of concentration of the polymer. As the concentration of polymer was increased, drug release from the matrix was extended. The release of drug from all implant formulations was found to be uniform and was extended over a period of 12 hrs. The implant formulations were found sterile, uniform in weight and size. The drug content was found to be in the range of 97.2-101.33%.Conclusion: Drug interaction studies revealed that there were no chemical interactions between temozolomide and polymers used in the study. Short-term stability studies of implants revealed that implants were stable, and there were no significant changes in the physical appearance and drug content of the implant formulations. The results of the study demonstrated that implantable drug delivery system of temozolomide can be formulated using hydrophilic polymer.

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