C(sp3)–H dehydrogenation and C(sp2)–H alkoxy carbonylation of inactivated cyclic amines towards functionalized N-heterocycles

2017 ◽  
Vol 53 (28) ◽  
pp. 4002-4005 ◽  
Author(s):  
Yan He ◽  
Fang Wang ◽  
Xinying Zhang ◽  
Xuesen Fan
Keyword(s):  
Cascade Reactions ◽  
Efficient Synthesis ◽  
Cyclic Amines

A novel and efficient synthesis of tetrahydropyridine-, dihydropyrrole-, and tetrahydroazepine-3-carboxylates via cascade reactions of cyclic amines with CO and alcohols is presented. To our knowledge, this should be the first example in which functionalized N-heterocycles were prepared through Pd-catalyzed C(sp3)–H dehydrogenation and C(sp2)–H carbonylation of cyclic amines.

Efficient Synthesis of Eight-Membered Nitrogen Heterocycles fromO-Propargylic Oximes by Rhodium-Catalyzed Cascade Reactions

2014 ◽  
Vol 20 (33) ◽  
pp. 10214-10219 ◽  
Author(s):  
Itaru Nakamura ◽  
Yoshinori Sato ◽  
Keisuke Takeda ◽  
Masahiro Terada
Keyword(s):  
Nitrogen Heterocycles ◽  
Cascade Reactions ◽  
Efficient Synthesis

Synthesis of the aglycon of aspafiliosides E and F based on cascade reactions

2016 ◽  
Vol 52 (9) ◽  
pp. 1942-1944 ◽  
Author(s):  
Jing-Jing Wu ◽  
Yong Shi ◽  
Wei-Sheng Tian
Keyword(s):  
Cascade Reactions ◽  
Efficient Synthesis ◽  
Cascade Processes

Herein, we describe an efficient synthesis of C17α-OH-tigogenin, which is the aglycon of aspafiliosides E and F. The synthesis features three cascade processes, which involve the iodo-lactonization of furostan-26-acid, a cascade hydrolysis/intramolecular SN2 process, and a cascade intramolecular redox-ketalization process.

Selective synthesis of β-nitrated N-heterocycles and N-nitroso-2-alkoxyamine aldehydes from inactivated cyclic amines promoted by tBuONO and oxoammonium salt

2019 ◽  
Vol 55 (82) ◽  
pp. 12372-12375 ◽  
Author(s):  
Yan He ◽  
Zhi Zheng ◽  
Yajie Liu ◽  
Jiajie Qiao ◽  
Xinying Zhang ◽  
...  
Keyword(s):  
Cascade Reactions ◽  
Selective Synthesis ◽  
Cyclic Amines ◽  
Oxoammonium Salt

Solvent-dependent-controlled selective synthesis of β-nitrated N-heterocycles and N-nitroso chain 2-alkoxyamine aldehydes has been successfully realized viatBuONO and oxoammonium salt promoted cascade reactions of inactivated cyclic amines.

Efficient synthesis of chiral cyclic acetals by metal and Brønsted acid co-catalyzed enantioselective four-component cascade reactions

2014 ◽  
Vol 50 (17) ◽  
pp. 2196-2198 ◽  
Author(s):  
Lin Qiu ◽  
Xin Guo ◽  
Chaoqun Ma ◽  
Huang Qiu ◽  
Shunying Liu ◽  
...  
Keyword(s):  
Michael Addition ◽  
Cascade Reactions ◽  
Bronsted Acid ◽  
Brønsted Acid ◽  
Efficient Synthesis ◽  
Mannich Reactions ◽  
Cyclic Acetals ◽  
Brönsted Acid

Four-component Mannich reactions subsequently followed by an intramolecular oxo-Michael addition were developed to efficiently produce chiral cyclic acetals with high diastereoselectivity and enantioselectivity.

ChemInform Abstract: Highly Diastereoselective Multicomponent Cascade Reactions: Efficient Synthesis of Functionalized 1-Indanols.

ChemInform ◽  
2013 ◽  
Vol 44 (23) ◽  
pp. no-no
Author(s):  
Jun Jiang ◽  
Xiaoyu Guan ◽  
Shunying Liu ◽  
Baiyan Ren ◽  
Xiaochu Ma ◽  
...  
Keyword(s):  
Cascade Reactions ◽  
Efficient Synthesis

Efficient Synthesis of Medium-Sized Cyclic Amines by Means of 2-Nitrobenzenesulfonamide

Synlett ◽  
2002 ◽  
Vol 2002 (05) ◽  
pp. 0697-0699 ◽  
Author(s):  
Toshiyuki Kan ◽  
Hideki Kobayashi ◽  
Tohru Fukuyama
Keyword(s):  
Efficient Synthesis ◽  
Cyclic Amines
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