Synthesis of the aglycon of aspafiliosides E and F based on cascade reactions

2016 ◽  
Vol 52 (9) ◽  
pp. 1942-1944 ◽  
Author(s):  
Jing-Jing Wu ◽  
Yong Shi ◽  
Wei-Sheng Tian
Keyword(s):  
Cascade Reactions ◽  
Efficient Synthesis ◽  
Cascade Processes

Herein, we describe an efficient synthesis of C17α-OH-tigogenin, which is the aglycon of aspafiliosides E and F. The synthesis features three cascade processes, which involve the iodo-lactonization of furostan-26-acid, a cascade hydrolysis/intramolecular SN2 process, and a cascade intramolecular redox-ketalization process.

Efficient Synthesis of Eight-Membered Nitrogen Heterocycles fromO-Propargylic Oximes by Rhodium-Catalyzed Cascade Reactions

2014 ◽  
Vol 20 (33) ◽  
pp. 10214-10219 ◽  
Author(s):  
Itaru Nakamura ◽  
Yoshinori Sato ◽  
Keisuke Takeda ◽  
Masahiro Terada
Keyword(s):  
Nitrogen Heterocycles ◽  
Cascade Reactions ◽  
Efficient Synthesis

scholarly journals Recent Advances in Enzymatic and Chemoenzymatic Cascade Processes

Catalysts ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 1258
Author(s):  
Noelia Losada-Garcia ◽  
Zaida Cabrera ◽  
Paulina Urrutia ◽  
Carla Garcia-Sanz ◽  
Alicia Andreu ◽  
...  
Keyword(s):  
Organic Chemistry ◽  
Solid Phase ◽  
Cascade Reactions ◽  
Review Article ◽  
The Novel ◽  
Enzyme Cascade ◽  
Cascade Processes ◽  
Novel Strategy ◽  
Substantial Interest

Cascade reactions have been described as efficient and universal tools, and are of substantial interest in synthetic organic chemistry. This review article provides an overview of the novel and recent achievements in enzyme cascade processes catalyzed by multi-enzymatic or chemoenzymatic systems. The examples here selected collect the advances related to the application of the sequential use of enzymes in natural or genetically modified combination; second, the important combination of enzymes and metal complex systems, and finally we described the application of biocatalytic biohybrid systems on in situ catalytic solid-phase as a novel strategy. Examples of efficient and interesting enzymatic catalytic cascade processes in organic chemistry, in the production of important industrial products, such as the designing of novel biosensors or bio-chemocatalytic systems for medicinal chemistry application, are discussed

C(sp3)–H dehydrogenation and C(sp2)–H alkoxy carbonylation of inactivated cyclic amines towards functionalized N-heterocycles

2017 ◽  
Vol 53 (28) ◽  
pp. 4002-4005 ◽  
Author(s):  
Yan He ◽  
Fang Wang ◽  
Xinying Zhang ◽  
Xuesen Fan
Keyword(s):  
Cascade Reactions ◽  
Efficient Synthesis ◽  
Cyclic Amines

A novel and efficient synthesis of tetrahydropyridine-, dihydropyrrole-, and tetrahydroazepine-3-carboxylates via cascade reactions of cyclic amines with CO and alcohols is presented. To our knowledge, this should be the first example in which functionalized N-heterocycles were prepared through Pd-catalyzed C(sp3)–H dehydrogenation and C(sp2)–H carbonylation of cyclic amines.

Efficient synthesis of chiral cyclic acetals by metal and Brønsted acid co-catalyzed enantioselective four-component cascade reactions

2014 ◽  
Vol 50 (17) ◽  
pp. 2196-2198 ◽  
Author(s):  
Lin Qiu ◽  
Xin Guo ◽  
Chaoqun Ma ◽  
Huang Qiu ◽  
Shunying Liu ◽  
...  
Keyword(s):  
Michael Addition ◽  
Cascade Reactions ◽  
Bronsted Acid ◽  
Brønsted Acid ◽  
Efficient Synthesis ◽  
Mannich Reactions ◽  
Cyclic Acetals ◽  
Brönsted Acid

Four-component Mannich reactions subsequently followed by an intramolecular oxo-Michael addition were developed to efficiently produce chiral cyclic acetals with high diastereoselectivity and enantioselectivity.

ChemInform Abstract: Highly Diastereoselective Multicomponent Cascade Reactions: Efficient Synthesis of Functionalized 1-Indanols.

ChemInform ◽  
2013 ◽  
Vol 44 (23) ◽  
pp. no-no
Author(s):  
Jun Jiang ◽  
Xiaoyu Guan ◽  
Shunying Liu ◽  
Baiyan Ren ◽  
Xiaochu Ma ◽  
...  
Keyword(s):  
Cascade Reactions ◽  
Efficient Synthesis

Synthesis of di(hetero)aryl sulfides by defluorinative sulfenylation of polyfluoroalkyl ketones with sodium sulfinates or arylsulfonyl chlorides

2020 ◽  
Vol 56 (61) ◽  
pp. 8699-8702
Author(s):  
Xue-Qiang Chu ◽  
Ting Xie ◽  
Ya-Wen Wang ◽  
Xiang-Rui Li ◽  
Weidong Rao ◽  
...  
Keyword(s):  
Transition Metal ◽  
Cascade Reactions ◽  
Efficient Synthesis ◽  
Metal Free ◽  
Aryl Sulfides ◽  
Aryl Sulfide

Cascade reactions of α-perfluoroalkyl ketones with sodium sulfinates or arylsulfonyl chlorides that allowed the efficient synthesis of fluoroalkylated di(hetero)aryl sulfide derivatives under transition metal-free conditions were developed.

ChemInform Abstract: Efficient Synthesis of Chiral Cyclic Acetals by Metal and Broensted Acid Co-Catalyzed Enantioselective Four-Component Cascade Reactions.

ChemInform ◽  
2014 ◽  
Vol 45 (20) ◽  
pp. no-no
Author(s):  
Lin Qiu ◽  
Xin Guo ◽  
Chaoqun Ma ◽  
Huang Qiu ◽  
Shunying Liu ◽  
...  
Keyword(s):  
Cascade Reactions ◽  
Efficient Synthesis ◽  
Cyclic Acetals
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