scholarly journals Sulfur dioxide prodrugs: triggered release of SO2via a click reaction

2017 ◽  
Vol 53 (8) ◽  
pp. 1370-1373 ◽  
Author(s):  
Wenyi Wang ◽  
Xingyue Ji ◽  
Zhenming Du ◽  
Binghe Wang
Keyword(s):  
Sulfur Dioxide ◽  
Click Reaction ◽  
Release Rates ◽  
Triggered Release ◽  
Tunable Release

SO2 prodrugs activated by a bioorthogonal click reaction with tunable release rates.

Esterase-sensitive sulfur dioxide prodrugs inspired by modified Julia olefination

2017 ◽  
Vol 53 (73) ◽  
pp. 10124-10127 ◽  
Author(s):  
Wenyi Wang ◽  
Binghe Wang
Keyword(s):  
Sulfur Dioxide ◽  
Release Rates ◽  
Tunable Release ◽  
Julia Olefination

Esterase-triggered SO2prodrugs with tunable release rates.

GSH-triggered release of sulfur dioxide gas to regulate redox balance for enhanced photodynamic therapy

2020 ◽  
Vol 56 (42) ◽  
pp. 5645-5648 ◽  
Author(s):  
Yu Zhang ◽  
Wei Shen ◽  
Peng Zhang ◽  
Li Chen ◽  
Chunsheng Xiao
Keyword(s):  
Photodynamic Therapy ◽  
Sulfur Dioxide ◽  
Tumor Cells ◽  
Redox Balance ◽  
Triggered Release ◽  
Promising Strategy

Herein, a promising strategy is explored to regulate redox balance in tumor cells by simultaneously consuming GSH and releasing SO2 gas for enhanced photodynamic therapy.

scholarly journals Enzyme-Responsive Nanoparticles and Coatings Made from Alginate/Peptide Ciprofloxacin Conjugates as Drug Release System

Antibiotics ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 653
Author(s):  
Yannick Bourgat ◽  
Carina Mikolai ◽  
Meike Stiesch ◽  
Philipp Klahn ◽  
Henning Menzel
Keyword(s):  
Drug Release ◽  
Antibacterial Agents ◽  
Click Reaction ◽  
Dipolar Cycloaddition ◽  
Postoperative Phase ◽  
Triggered Release ◽  
Amine Nitrogen ◽  
Aqueous Environments ◽  
Linker Group ◽  
Model Drug

Infection-controlled release of antibacterial agents is of great importance, particularly for the control of peri-implant infections in the postoperative phase. Polymers containing antibiotics bound via enzymatically cleavable linkers could provide access to drug release systems that could accomplish this. Dispersions of nanogels were prepared by ionotropic gelation of alginate with poly-L-lysine, which was conjugated with ciprofloxacin as model drug via a copper-free 1,3-dipolar cycloaddition (click reaction). The nanogels are stable in dispersion and form films which are stable in aqueous environments. However, both the nanogels and the layers are degraded in the presence of an enzyme and the ciprofloxacin is released. The efficacy of the released drug against Staphylococcus aureus is negatively affected by the residues of the linker. Both the acyl modification of the amine nitrogen in ciprofloxacin and the sterically very demanding linker group with three annellated rings could be responsible for this. However the basic feasibility of the principle for enzyme-triggered release of drugs was successfully demonstrated.

scholarly journals Near-Infrared Light-Responsive Shell-Crosslinked Micelles of Poly(d,l-lactide)-b-poly((furfuryl methacrylate)-co-(N-acryloylmorpholine)) Prepared by Diels–Alder Reaction for the Triggered Release of Doxorubicin

Materials ◽  
2021 ◽  
Vol 14 (24) ◽  
pp. 7913
Author(s):  
Sonyabapu Yadav ◽  
Kalyan Ramesh ◽  
Parveen Kumar ◽  
Sung-Han Jo ◽  
Seong II Yoo ◽  
...  
Keyword(s):  
Drug Release ◽  
Near Infrared ◽  
Click Reaction ◽  
In Vitro Cytotoxicity ◽  
Diels Alder ◽  
Infrared Light ◽  
Burst Release ◽  
Crosslinking Reaction ◽  
Triggered Release

In the present study, we developed near-infrared (NIR)-responsive shell-crosslinked (SCL) micelles using the Diels–Alder (DA) click reaction between an amphiphilic copolymer poly(d,l-lactide)20-b-poly((furfuryl methacrylate)10-co-(N-acryloylmorpholine)78) (PLA20-b-P(FMA10-co-NAM78)) and a diselenide-containing crosslinker, bis(maleimidoethyl) 3,3′-diselanediyldipropionoate (BMEDSeDP). The PLA20-b-P(FMA10-co-NAM78) copolymer was synthesized by RAFT polymerization of FMA and NAM using a PLA20-macro-chain transfer agent (PLA20-CTA). The DA reaction between BMEDSeDP and the furfuryl moieties in the copolymeric micelles in water resulted in the formation of SCL micelles. The SCL micelles were analyzed by 1H-NMR, FE-SEM, and DLS. An anticancer drug, doxorubicin (DOX), and an NIR sensitizer, indocyanine green (ICG), were effectively incorporated into the SCL micelles during the crosslinking reaction. The DOX/ICG-loaded SCL micelles showed pH- and NIR-responsive drug release, where burst release was observed under NIR laser irradiation. The in vitro cytotoxicity analysis demonstrated that the SCL was not cytotoxic against normal HFF-1 cells, while DOX/ICG-loaded SCL micelles exhibited significant antitumor activity toward HeLa cells. Thus, the SCL micelles of PLA20-b-P(FMA10-co-NAM78) can be used as a potential delivery vehicle for the controlled drug release in cancer therapy.

Coaxial nanotubes of stimuli responsive polymers with tunable release kinetics

Soft Matter ◽  
2015 ◽  
Vol 11 (41) ◽  
pp. 8069-8075 ◽  
Author(s):  
Efe Armagan ◽  
Gozde Ozaydin Ince
Keyword(s):  
Release Kinetics ◽  
Polymer Chemistry ◽  
Stimuli Responsive ◽  
Release Rates ◽  
Polymer Layers ◽  
Stimuli Responsive Polymers ◽  
Responsive Polymers ◽  
Responsive Polymer ◽  
Tunable Release ◽  
Stimuli Responsive Polymer

Coaxial nanotubes with different stimuli responsive polymer layers demonstrate triggered response with release rates that can be controlled by tuning the polymer chemistry.

Redox tunable delivery systems: sweet block copolymer micelles via thiol–(bromo)maleimide conjugation

2016 ◽  
Vol 52 (82) ◽  
pp. 12202-12205 ◽  
Author(s):  
Antoine Petrelli ◽  
Redouane Borsali ◽  
Sébastien Fort ◽  
Sami Halila
Keyword(s):  
Block Copolymer ◽  
Click Reaction ◽  
Nile Red ◽  
Delivery Systems ◽  
Tunable Release ◽  
Block Copolymer Micelles ◽  
Copolymer Micelles

A tunable release of encapsulated Nile Red from xyloglucan-oligosaccharides-block-polycaprolactone obtained by thiol–(bromo)maleimide click reaction was successfully achieved by mixing their Gluathione-responsiveness.

Inside Cover: Esterase-Sensitive Prodrugs with Tunable Release Rates and Direct Generation of Hydrogen Sulfide (Angew. Chem. Int. Ed. 14/2016)

2016 ◽  
Vol 55 (14) ◽  
pp. 4370-4370 ◽  
Author(s):  
Yueqin Zheng ◽  
Bingchen Yu ◽  
Kaili Ji ◽  
Zhixiang Pan ◽  
Vayou Chittavong ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Release Rates ◽  
Tunable Release ◽  
Direct Generation

scholarly journals Esterase-Sensitive Prodrugs with Tunable Release Rates and Direct Generation of Hydrogen Sulfide

2016 ◽  
Vol 55 (14) ◽  
pp. 4514-4518 ◽  
Author(s):  
Yueqin Zheng ◽  
Bingchen Yu ◽  
Kaili Ji ◽  
Zhixiang Pan ◽  
Vayou Chittavong ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Release Rates ◽  
Tunable Release ◽  
Direct Generation

scholarly journals Correction: GSH-triggered release of sulfur dioxide gas to regulate redox balance for enhanced photodynamic therapy

2020 ◽  
Vol 56 (45) ◽  
pp. 6155-6155
Author(s):  
Yu Zhang ◽  
Wei Shen ◽  
Peng Zhang ◽  
Li Chen ◽  
Chunsheng Xiao
Keyword(s):  
Photodynamic Therapy ◽  
Sulfur Dioxide ◽  
Redox Balance ◽  
Triggered Release

Correction for ‘GSH-triggered release of sulfur dioxide gas to regulate redox balance for enhanced photodynamic therapy’ by Yu Zhang et al., Chem. Commun., 2020, DOI: 10.1039/d0cc00470g.

Click and Release: SO2 Prodrugs with Tunable Release Rates

2017 ◽  
Vol 19 (4) ◽  
pp. 818-821 ◽  
Author(s):  
Xingyue Ji ◽  
Eman M. El-labbad ◽  
Kaili Ji ◽  
Deena S. Lasheen ◽  
Rabah A. T. Serya ◽  
...  
Keyword(s):  
Release Rates ◽  
Tunable Release
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