Inside Cover: Esterase-Sensitive Prodrugs with Tunable Release Rates and Direct Generation of Hydrogen Sulfide (Angew. Chem. Int. Ed. 14/2016)

2016 ◽  
Vol 55 (14) ◽  
pp. 4370-4370 ◽  
Author(s):  
Yueqin Zheng ◽  
Bingchen Yu ◽  
Kaili Ji ◽  
Zhixiang Pan ◽  
Vayou Chittavong ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Release Rates ◽  
Tunable Release ◽  
Direct Generation

scholarly journals Esterase-Sensitive Prodrugs with Tunable Release Rates and Direct Generation of Hydrogen Sulfide

2016 ◽  
Vol 55 (14) ◽  
pp. 4514-4518 ◽  
Author(s):  
Yueqin Zheng ◽  
Bingchen Yu ◽  
Kaili Ji ◽  
Zhixiang Pan ◽  
Vayou Chittavong ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Release Rates ◽  
Tunable Release ◽  
Direct Generation

Esterase-Sensitive Prodrugs with Tunable Release Rates and Direct Generation of Hydrogen Sulfide

2016 ◽  
Vol 128 (14) ◽  
pp. 4590-4594 ◽  
Author(s):  
Yueqin Zheng ◽  
Bingchen Yu ◽  
Kaili Ji ◽  
Zhixiang Pan ◽  
Vayou Chittavong ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Release Rates ◽  
Tunable Release ◽  
Direct Generation

scholarly journals Innentitelbild: Esterase-Sensitive Prodrugs with Tunable Release Rates and Direct Generation of Hydrogen Sulfide (Angew. Chem. 14/2016)

2016 ◽  
Vol 128 (14) ◽  
pp. 4444-4444
Author(s):  
Yueqin Zheng ◽  
Bingchen Yu ◽  
Kaili Ji ◽  
Zhixiang Pan ◽  
Vayou Chittavong ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Release Rates ◽  
Tunable Release ◽  
Direct Generation

Esterase-sensitive sulfur dioxide prodrugs inspired by modified Julia olefination

2017 ◽  
Vol 53 (73) ◽  
pp. 10124-10127 ◽  
Author(s):  
Wenyi Wang ◽  
Binghe Wang
Keyword(s):  
Sulfur Dioxide ◽  
Release Rates ◽  
Tunable Release ◽  
Julia Olefination

Esterase-triggered SO2prodrugs with tunable release rates.

Coaxial nanotubes of stimuli responsive polymers with tunable release kinetics

Soft Matter ◽  
2015 ◽  
Vol 11 (41) ◽  
pp. 8069-8075 ◽  
Author(s):  
Efe Armagan ◽  
Gozde Ozaydin Ince
Keyword(s):  
Release Kinetics ◽  
Polymer Chemistry ◽  
Stimuli Responsive ◽  
Release Rates ◽  
Polymer Layers ◽  
Stimuli Responsive Polymers ◽  
Responsive Polymers ◽  
Responsive Polymer ◽  
Tunable Release ◽  
Stimuli Responsive Polymer

Coaxial nanotubes with different stimuli responsive polymer layers demonstrate triggered response with release rates that can be controlled by tuning the polymer chemistry.

scholarly journals Sulfur dioxide prodrugs: triggered release of SO2via a click reaction

2017 ◽  
Vol 53 (8) ◽  
pp. 1370-1373 ◽  
Author(s):  
Wenyi Wang ◽  
Xingyue Ji ◽  
Zhenming Du ◽  
Binghe Wang
Keyword(s):  
Sulfur Dioxide ◽  
Click Reaction ◽  
Release Rates ◽  
Triggered Release ◽  
Tunable Release

SO2 prodrugs activated by a bioorthogonal click reaction with tunable release rates.

Click and Release: SO2 Prodrugs with Tunable Release Rates

2017 ◽  
Vol 19 (4) ◽  
pp. 818-821 ◽  
Author(s):  
Xingyue Ji ◽  
Eman M. El-labbad ◽  
Kaili Ji ◽  
Deena S. Lasheen ◽  
Rabah A. T. Serya ◽  
...  
Keyword(s):  
Release Rates ◽  
Tunable Release

Endogenous hydrogen sulfide sulfhydrates IKKβ at cysteine 179 to control pulmonary artery endothelial cell inflammation

2019 ◽  
Vol 133 (20) ◽  
pp. 2045-2059 ◽  
Author(s):  
Da Zhang ◽  
Xiuli Wang ◽  
Siyao Chen ◽  
Selena Chen ◽  
Wen Yu ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Endothelial Cell ◽  
Pulmonary Artery ◽  
Cell Model ◽  
Site Directed Mutagenesis ◽  
Critical Event ◽  
Hypertensive Rats ◽  
Pulmonary Artery Endothelial Cell

Abstract Background: Pulmonary artery endothelial cell (PAEC) inflammation is a critical event in the development of pulmonary arterial hypertension (PAH). However, the pathogenesis of PAEC inflammation remains unclear. Methods: Purified recombinant human inhibitor of κB kinase subunit β (IKKβ) protein, human PAECs and monocrotaline-induced pulmonary hypertensive rats were employed in the study. Site-directed mutagenesis, gene knockdown or overexpression were conducted to manipulate the expression or activity of a target protein. Results: We showed that hydrogen sulfide (H2S) inhibited IKKβ activation in the cell model of human PAEC inflammation induced by monocrotaline pyrrole-stimulation or knockdown of cystathionine γ-lyase (CSE), an H2S generating enzyme. Mechanistically, H2S was proved to inhibit IKKβ activity directly via sulfhydrating IKKβ at cysteinyl residue 179 (C179) in purified recombinant IKKβ protein in vitro, whereas thiol reductant dithiothreitol (DTT) reversed H2S-induced IKKβ inactivation. Furthermore, to demonstrate the significance of IKKβ sulfhydration by H2S in the development of PAEC inflammation, we mutated C179 to serine (C179S) in IKKβ. In purified IKKβ protein, C179S mutation of IKKβ abolished H2S-induced IKKβ sulfhydration and the subsequent IKKβ inactivation. In human PAECs, C179S mutation of IKKβ blocked H2S-inhibited IKKβ activation and PAEC inflammatory response. In pulmonary hypertensive rats, C179S mutation of IKKβ abolished the inhibitory effect of H2S on IKKβ activation and pulmonary vascular inflammation and remodeling. Conclusion: Collectively, our in vivo and in vitro findings demonstrated, for the first time, that endogenous H2S directly inactivated IKKβ via sulfhydrating IKKβ at Cys179 to inhibit nuclear factor-κB (NF-κB) pathway activation and thereby control PAEC inflammation in PAH.

Limnological characteristics, community metabolism and management strategies of a coastal sinkhole in Cuba (Cenote Jennifer)

2020 ◽  
Vol 56 ◽  
pp. 24
Author(s):  
Roberto González-De Zayas ◽  
Liosban Lantigua Ponce de León ◽  
Liezel Guerra Rodríguez ◽  
Felipe Matos Pupo ◽  
Leslie Hernández-Fernández
Keyword(s):  
Hydrogen Sulfide ◽  
Primary Productivity ◽  
Major Ions ◽  
Saline Water ◽  
Management Strategies ◽  
Tourist Destination ◽  
Community Metabolism ◽  
Morphological Studies ◽  
Made In ◽  
Limnological Parameters

The Cenote Jennifer is an important and unique aquatic sinkhole in Cayo Coco (Jardines del Rey Tourist Destination) that has brackish to saline water. Two samplings were made in 1998 and 2009, and 4 metabolism community experiments in 2009. Some limnological parameters were measured in both samplings (temperature, salinity, pH, dissolved oxygen major ions, hydrogen sulfide, nutrients and others). Community metabolism was measured through incubated oxygen concentration in clear and dark oxygen bottles. Results showed that the sinkhole limnology depends on rainfall and light incidence year, with some stratification episodes, due to halocline or oxycline presence, rather than thermocline. The sinkhole water was oligotrophic (total nitrogen of 41.5 ± 22.2 μmol l−1 and total phosphorus of 0.3 ± 0.2 μmol l−1) and with low productivity (gross primary productivity of 63.0 mg C m−2 d−1). Anoxia and hypoxia were present at the bottom with higher levels of hydrogen sulfide, lower pH and restricted influence of the adjacent sea (2 km away). To protect the Cenote Jennifer, tourist exploitation should be avoided and more resources to ecological and morphological studies should be allocated, and eventually use this aquatic system only for specialized diving. For conservation purposes, illegal garbage disposal in the surrounding forest should end.

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