scholarly journals Correction: GSH-triggered release of sulfur dioxide gas to regulate redox balance for enhanced photodynamic therapy

2020 ◽  
Vol 56 (45) ◽  
pp. 6155-6155
Author(s):  
Yu Zhang ◽  
Wei Shen ◽  
Peng Zhang ◽  
Li Chen ◽  
Chunsheng Xiao
Keyword(s):  
Photodynamic Therapy ◽  
Sulfur Dioxide ◽  
Redox Balance ◽  
Triggered Release

Correction for ‘GSH-triggered release of sulfur dioxide gas to regulate redox balance for enhanced photodynamic therapy’ by Yu Zhang et al., Chem. Commun., 2020, DOI: 10.1039/d0cc00470g.

GSH-triggered release of sulfur dioxide gas to regulate redox balance for enhanced photodynamic therapy

2020 ◽  
Vol 56 (42) ◽  
pp. 5645-5648 ◽  
Author(s):  
Yu Zhang ◽  
Wei Shen ◽  
Peng Zhang ◽  
Li Chen ◽  
Chunsheng Xiao
Keyword(s):  
Photodynamic Therapy ◽  
Sulfur Dioxide ◽  
Tumor Cells ◽  
Redox Balance ◽  
Triggered Release ◽  
Promising Strategy

Herein, a promising strategy is explored to regulate redox balance in tumor cells by simultaneously consuming GSH and releasing SO2 gas for enhanced photodynamic therapy.

scholarly journals Proof-of-principle for two-stage photodynamic therapy: hypoxia triggered release of singlet oxygen

2020 ◽  
Vol 56 (94) ◽  
pp. 14793-14796
Author(s):  
Seylan Ayan ◽  
Gurcan Gunaydin ◽  
Nisa Yesilgul-Mehmetcik ◽  
M. Emre Gedik ◽  
Ozlem Seven ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Singlet Oxygen ◽  
Triggered Release ◽  
Two Stage ◽  
Hypoxic Conditions ◽  
Proof Of Principle

Singlet oxygen, which is stored in the form of an endoperoxide, released under hypoxic conditions typically prevalent in most tumors.

scholarly journals Sulfur dioxide prodrugs: triggered release of SO2via a click reaction

2017 ◽  
Vol 53 (8) ◽  
pp. 1370-1373 ◽  
Author(s):  
Wenyi Wang ◽  
Xingyue Ji ◽  
Zhenming Du ◽  
Binghe Wang
Keyword(s):  
Sulfur Dioxide ◽  
Click Reaction ◽  
Release Rates ◽  
Triggered Release ◽  
Tunable Release

SO2 prodrugs activated by a bioorthogonal click reaction with tunable release rates.

Light-triggered release of drug conjugates for an efficient combination of chemotherapy and photodynamic therapy

2018 ◽  
Vol 6 (5) ◽  
pp. 997-1001 ◽  
Author(s):  
Lin Liu ◽  
Ruibo Wang ◽  
Chunran Wang ◽  
Jinze Wang ◽  
Li Chen ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Triggered Release ◽  
Drug Conjugates ◽  
Photodynamic Therapy Of Cancer ◽  
Polymeric Drug

Herein, we present a series of light-triggered porphyrin-based polymeric drug conjugates PSDTD-m for combined chemo-photodynamic therapy of cancer.

Methylene blue as a far-red light-mediated photocleavable multifunctional ligand

2020 ◽  
Vol 56 (11) ◽  
pp. 1673-1676 ◽  
Author(s):  
Huy Minh Dao ◽  
Chang-Hee Whang ◽  
Vijay Kumar Shankar ◽  
Yan-Hong Wang ◽  
Ikhlas A. Khan ◽  
...  
Keyword(s):  
Methylene Blue ◽  
Photodynamic Therapy ◽  
Red Light ◽  
Triggered Release ◽  
Fluorescence Switch ◽  
Conjugated Compounds ◽  
Multifunctional Ligand ◽  
Conjugated Molecule

Methylene blue (MB) was discovered as a multifunctional far-red photocleavable ligand capable of rendering a series of MB conjugated compounds with off-to-on fluorescence switch, photodynamic therapy and triggered release of conjugated molecule.

scholarly journals Engineered macrophages as near-infrared light activated drug vectors for chemo-photodynamic therapy of primary and bone metastatic breast cancer

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Yanjuan Huang ◽  
Zilin Guan ◽  
Xiuling Dai ◽  
Yifeng Shen ◽  
Qin Wei ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Photodynamic Therapy ◽  
Metastatic Breast Cancer ◽  
Near Infrared ◽  
Metastatic Breast ◽  
Infrared Light ◽  
Triggered Release ◽  
Metastatic Tumors ◽  
Primary Tumors ◽  
Formidable Challenge

AbstractPatients with primary and bone metastatic breast cancer have significantly reduced survival and life quality. Due to the poor drug delivery efficiency of anti-metastasis therapy and the limited response rate of immunotherapy for breast cancer, effective treatment remains a formidable challenge. In this work, engineered macrophages (Oxa(IV)@ZnPc@M) carrying nanomedicine containing oxaliplatin prodrug and photosensitizer are designed as near-infrared (NIR) light-activated drug vectors, aiming to achieve enhanced chemo/photo/immunotherapy of primary and bone metastatic tumors. Oxa(IV)@ZnPc@M exhibits an anti-tumor M1 phenotype polarization and can efficiently home to primary and bone metastatic tumors. Additionally, therapeutics inside Oxa(IV)@ZnPc@M undergo NIR triggered release, which can kill primary tumors via combined chemo-photodynamic therapy and induce immunogenic cell death simultaneously. Oxa(IV)@ZnPc@M combined with anti-PD-L1 can eliminate primary and bone metastatic tumors, activate tumor-specific antitumor immune response, and improve overall survival with limited systemic toxicity. Therefore, this all-in-one macrophage provides a treatment platform for effective therapy of primary and bone metastatic tumors.

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