Naphthalene-fused BODIPY near-infrared dye as a stable contrast agent for in vivo photoacoustic imaging

2016 ◽  
Vol 52 (77) ◽  
pp. 11504-11507 ◽  
Author(s):  
Yong Ni ◽  
Ravi K. Kannadorai ◽  
Juanjuan Peng ◽  
Sidney W.-K. Yu ◽  
Young-Tae Chang ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Near Infrared Dye

Naphthalene-fused BODIPY near infrared dye (Na-BD) was synthesized and used as a stable contrast agent for in vivo photoacoustic imaging.

scholarly journals Photoacoustic molecular imaging using combined acupuncture and gold nanorods as a composite contrast agent

2019 ◽  
Vol 12 (03) ◽  
pp. 1941004
Author(s):  
Dan Wu ◽  
Xinxin Zhang ◽  
Jian Rong ◽  
Huabei Jiang
Keyword(s):  
Contrast Agent ◽  
Contrast Enhancement ◽  
Mouse Brain ◽  
Gold Nanorods ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Local Concentration ◽  
Quantitative Results ◽  
Zusanli Acupoint

In this study, we developed a novel photoacoustic imaging technique based on poly (ethyleneglycol)-coated (PEGylated) gold nanorods (PEG-GNRs) (as the contrast agent) combined with traditional Chinese medicine (TCM) acupuncture (as the auxiliary method) for quantitatively monitoring contrast enhancement in the vasculature of a mouse brain in vivo. This study takes advantage of the strong near-infrared absorption (peak at [Formula: see text][Formula: see text]nm) of GNRs and the ability to adjust the hemodynamics of acupuncture. Experimental results show that photoacoustic tomography (PAT) successfully reveals the optical absorption variation of the vasculature of the mouse brain in response to intravenous administration of GNRs and acupuncture at the Zusanli acupoint (ST36) both individually and combined. The quantitative measurement of contrast enhancement indicates that the composite contrast agents (integration of acupuncture and GNRs) would greatly enhance the photoacoustic imaging contrast. The quantitative results also have the potential to estimate the local concentration of GNRs and even the real-time effects of acupuncture.

Near-Infrared Dye-Conjugated Amphiphilic Hyaluronic Acid Derivatives as a Dual Contrast Agent for In Vivo Optical and Photoacoustic Tumor Imaging

2014 ◽  
Vol 16 (1) ◽  
pp. 219-227 ◽  
Author(s):  
Koji Miki ◽  
Tatsuhiro Inoue ◽  
Yasuhito Kobayashi ◽  
Katsuya Nakano ◽  
Hideki Matsuoka ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Contrast Agent ◽  
Near Infrared ◽  
Tumor Imaging ◽  
Near Infrared Dye

scholarly journals Polypyrrole–methylene blue nanoparticles as a single multifunctional nanoplatform for near-infrared photo-induced therapy and photoacoustic imaging

RSC Advances ◽  
2017 ◽  
Vol 7 (56) ◽  
pp. 35027-35037 ◽  
Author(s):  
Thi Tuong Vy Phan ◽  
Subramaniyan Bharathiraja ◽  
Van Tu Nguyen ◽  
Madhappan Santha Moorthy ◽  
Panchanathan Manivasagan ◽  
...  
Keyword(s):  
Methylene Blue ◽  
Contrast Agent ◽  
Near Infrared ◽  
Photoacoustic Imaging

A novel contrast agent with broad NIR absorbing properties for combined photo-induced therapy and photoacoustic imaging.

scholarly journals Efficient Photoacoustic Imaging With Biomimetic Mesoporous Silica-Based Nanoparticles

2021 ◽  
Vol 9 ◽  
Author(s):  
Chuangjia Huang ◽  
Xiaoling Guan ◽  
Hui Lin ◽  
Lu Liang ◽  
Yingling Miao ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Near Infrared ◽  
Ex Vivo ◽  
Photoacoustic Imaging ◽  
Mesoporous Silica Nanoparticles ◽  
Good Biocompatibility ◽  
Targeting Ability ◽  
Body Clearance

Indocyanine green (ICG), a near-infrared (NIR) fluorescent dye approved by the Food and Drug Administration (FDA), has been extensively used as a photoacoustic (PA) probe for PA imaging. However, its practical application is limited by poor photostability in water, rapid body clearance, and non-specificity. Herein, we fabricated a novel biomimetic nanoprobe by coating ICG-loaded mesoporous silica nanoparticles with the cancer cell membrane (namely, CMI) for PA imaging. This probe exhibited good dispersion, large loading efficiency, good biocompatibility, and homologous targeting ability to Hela cells in vitro. Furthermore, the in vivo and ex vivo PA imaging on Hela tumor-bearing nude mice demonstrated that CMI could accumulate in tumor tissue and display a superior PA imaging efficacy compared with free ICG. All these results demonstrated that CMI might be a promising contrast agent for PA imaging of cervical carcinoma.

Antimonene Nanoflakes as a Photoacoustic Imaging Contrast Agent for Tumor in vivo Imaging

2020 ◽  
Vol 47 (2) ◽  
pp. 0207033
Author(s):  
于静文 Yu Jingwen ◽  
王秀翃 Wang Xiuhong ◽  
冯金超 Feng Jinchao ◽  
张娜 Zhang Na ◽  
王璞 Wang Pu
Keyword(s):  
Contrast Agent ◽  
In Vivo Imaging ◽  
Photoacoustic Imaging ◽  
Imaging Contrast Agent

Surfactant-Stripped Micelles of Near Infrared Dye and Paclitaxel for Photoacoustic Imaging Guided Photothermal-Chemotherapy

Small ◽  
2018 ◽  
Vol 14 (44) ◽  
pp. 1802991 ◽  
Author(s):  
Yicheng Zhang ◽  
Liangzhu Feng ◽  
Jun Wang ◽  
Danlei Tao ◽  
Chao Liang ◽  
...  
Keyword(s):  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Near Infrared Dye

scholarly journals Photoacoustic imaging with an acoustic lens detects prostate cancer cells labeled with PSMA-targeting near-infrared dye-conjugates

2016 ◽  
Vol 21 (6) ◽  
pp. 066019 ◽  
Author(s):  
Vikram Dogra ◽  
Bhargava Chinni ◽  
Shalini Singh ◽  
Hans Schmitthenner ◽  
Navalgund Rao ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Prostate Cancer Cells ◽  
Acoustic Lens ◽  
Near Infrared Dye

scholarly journals Photoacoustic Properties of Polypyrrole Nanoparticles

Nanomaterials ◽  
2021 ◽  
Vol 11 (9) ◽  
pp. 2457
Author(s):  
Peter Keša ◽  
Monika Paúrová ◽  
Michal Babič ◽  
Tomáš Heizer ◽  
Petr Matouš ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Photoacoustic Imaging ◽  
Particle Surface ◽  
Photoacoustic Signal ◽  
Ammonium Persulphate ◽  
Coated Nanoparticles ◽  
Polypyrrole Nanoparticles ◽  
Signal Dependence

Photoacoustic imaging, an emerging modality, provides supplemental information to ultrasound imaging. We investigated the properties of polypyrrole nanoparticles, which considerably enhance contrast in photoacoustic images, in relation to the synthesis procedure and to their size. We prepared polypyrrole nanoparticles by water-based redox precipitation polymerization in the presence of ammonium persulphate (ratio nPy:nOxi 1:0.5, 1:1, 1:2, 1:3, 1:5) or iron(III) chloride (nPy:nOxi 1:2.3) acting as an oxidant. To stabilize growing nanoparticles, non-ionic polyvinylpyrrolidone was used. The nanoparticles were characterized and tested as a photoacoustic contrast agent in vitro on an imaging platform combining ultrasound and photoacoustic imaging. High photoacoustic signals were obtained with lower ratios of the oxidant (nPy:nAPS ≥ 1:2), which corresponded to higher number of conjugated bonds in the polymer. The increasing portion of oxidized structures probably shifted the absorption spectra towards shorter wavelengths. A strong photoacoustic signal dependence on the nanoparticle size was revealed; the signal linearly increased with particle surface. Coated nanoparticles were also tested in vivo on a mouse model. To conclude, polypyrrole nanoparticles represent a promising contrast agent for photoacoustic imaging. Variations in the preparation result in varying photoacoustic properties related to their structure and allow to optimize the nanoparticles for in vivo imaging.

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