scholarly journals In vivo photoacoustic imaging of chemotherapy-induced apoptosis in squamous cell carcinoma using a near-infrared caspase-9 probe

2011 ◽  
Vol 16 (11) ◽  
pp. 116026 ◽  
Author(s):  
Qiuhong Yang ◽  
Huizhong Cui ◽  
Shuang Cai ◽  
Xinmai Yang ◽  
M. Laird Forrest
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Caspase 9 ◽  
Induced Apoptosis

Luteolin Induces Apoptosis in Oral Squamous Cancer Cells

2008 ◽  
Vol 87 (4) ◽  
pp. 401-406 ◽  
Author(s):  
S.-F. Yang ◽  
W.-E. Yang ◽  
H.-R. Chang ◽  
S.-C. Chu ◽  
Y.-S. Hsieh
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Flavonoid Compound ◽  
Caspase 9 ◽  
Continuous Administration ◽  
Apoptotic Protein ◽  
Squamous Cancer ◽  
Induced Apoptosis

Oral squamous cell carcinoma is the most common malignancy of the oral cavity, and treatment approaches are inadequate. Luteolin, a natural flavonoid compound, has been shown to have anti-tumorigenic properties on various types of tumors. Therefore, we hypothesized that luteolin has anti-tumorigenic properties for oral squamous cell carcinoma, and may provide effective chemotherapy. Results revealed that luteolin reduced the viability of SCC-4 cells and induced apoptosis by decreasing the expression of cyclin-dependent kinase (CDKs), cyclins, and phosphor- retinoblastoma (p-Rb) anti-apoptotic protein, but increased the expression of pro-apoptotic proteins and activated caspase 9 and 3, with a concomitant increase in the levels of cleaved poly-ADP-ribose polymerase (PARP). Combination treatment of luteolin with paclitaxel enhanced the cytotoxic effect of paclitaxel in SCC-4 cells, and continuous administration of luteolin suppressed the growth of xenograft tumors in nude mice. These results suggest that luteolin could be an effective chemotherapeutic agent for the treatment of oral squamous cell carcinoma.

STAT1 Activation-Induced Apoptosis of Esophageal Squamous Cell Carcinoma Cells In Vivo

2006 ◽  
Vol 14 (4) ◽  
pp. 1405-1415 ◽  
Author(s):  
Junichi Kaganoi ◽  
Go Watanabe ◽  
Michio Okabe ◽  
Shiro Nagatani ◽  
Atsushi Kawabe ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Carcinoma Cells ◽  
Induced Apoptosis

Anti-PD-L1-modified and ATRA-loaded nanoparticles for immuno-treatment of oral dysplasia and oral squamous cell carcinoma

Nanomedicine ◽  
2020 ◽  
Vol 15 (10) ◽  
pp. 951-968 ◽  
Author(s):  
Xiao-Jie Chen ◽  
Xue-Qiong Zhang ◽  
Ming-Xiu Tang ◽  
Qi Liu ◽  
Gang Zhou
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Squamous Carcinoma ◽  
Oral Dysplasia ◽  
Squamous Carcinoma Cells ◽  
Induced Apoptosis

Aim: To develop nanomedicines for immuno-therapy of oral dysplasia and oral squamous cell carcinoma. Materials & methods: All-trans retinoic acid (ATRA)-poly(lactide-co-glycolide acid) (PLGA)-poly(ethylene glycol) (PEG)-programmed death-ligand 1 (PD-L1) nanomedicines were fabricated by loading ATRA into PLGA-PEG nanocarriers and modification using an anti-PD-L1 antibody. Results: ATRA-PLGA-PEG-PD-L1 nanoparticles showed fast cellular uptake, significantly inhibited proliferation and induced apoptosis in DOK and CAL27 cells. Moreover, in C3H tumor-bearing mice, ATRA-PLGA-PEG-PD-L1 nanoparticles more specifically targeted tumor cells, enhanced anticancer activity and reduced side effects when compared with free ATRA. Furthermore, CD8+ T cells were activated around PD-L1 positive cells in the tumor microenvironment after treatment. Conclusion: ATRA-PLGA-PEG-PD-L1 nanoparticles had low toxicity, high biocompatibility and specifically targeted oral dysplasia and squamous carcinoma cells both in vitro and in vivo.

Photoacoustic imaging of chemotherapy-induced apoptosis in squamous cell carcinoma

2012 ◽  
Author(s):  
Quihong Yang ◽  
Huizhong Cui ◽  
Shuang Cai ◽  
Xinmai Yang ◽  
M. Laird Forrest
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Photoacoustic Imaging ◽  
Induced Apoptosis

Comparison of in vivo and in vitro prostaglandin E production by squamous cell carcinoma of the head and neck

1994 ◽  
Vol 111 (3) ◽  
pp. 189-196 ◽  
Author(s):  
C SNYDERMAN ◽  
I KLAPAN ◽  
M MILANOVICH ◽  
D HEO ◽  
R WAGNER ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Prostaglandin E
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