Near-Infrared Dye-Conjugated Amphiphilic Hyaluronic Acid Derivatives as a Dual Contrast Agent for In Vivo Optical and Photoacoustic Tumor Imaging

2014 ◽  
Vol 16 (1) ◽  
pp. 219-227 ◽  
Author(s):  
Koji Miki ◽  
Tatsuhiro Inoue ◽  
Yasuhito Kobayashi ◽  
Katsuya Nakano ◽  
Hideki Matsuoka ◽  
...  
Keyword(s):  
Hyaluronic Acid ◽  
Contrast Agent ◽  
Near Infrared ◽  
Tumor Imaging ◽  
Near Infrared Dye

scholarly journals Near-infrared dye-loaded magnetic nanoparticles as photoacoustic contrast agent for enhanced tumor imaging

2016 ◽  
Vol 13 (3) ◽  
pp. 349-359 ◽  
Author(s):  
Chuang Gao ◽  
Chuang Gao ◽  
Zi-Jian Deng ◽  
Dong Peng ◽  
Yu-Shen Jin ◽  
...  
Keyword(s):  
Magnetic Nanoparticles ◽  
Contrast Agent ◽  
Near Infrared ◽  
Tumor Imaging ◽  
Near Infrared Dye

A fluorinated aza-BODIPY derivative for NIR fluorescence/PA/19F MR tri-modality in vivo imaging

2019 ◽  
Vol 55 (42) ◽  
pp. 5851-5854 ◽  
Author(s):  
Lianhua Liu ◽  
Yaping Yuan ◽  
Yuqi Yang ◽  
Michael T. McMahon ◽  
Shizhen Chen ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Small Molecule ◽  
In Vivo Imaging ◽  
Near Infrared ◽  
Tumor Imaging ◽  
Near Infrared Fluorescence ◽  
Highly Efficient ◽  
Nir Fluorescence

A fluorinated aza-BODIPY derivative BDPF was developed as a small molecule contrast agent, which displayed highly efficient near infrared fluorescence/photoacoustic/19F MR tri-modality tumor imaging.

Naphthalene-fused BODIPY near-infrared dye as a stable contrast agent for in vivo photoacoustic imaging

2016 ◽  
Vol 52 (77) ◽  
pp. 11504-11507 ◽  
Author(s):  
Yong Ni ◽  
Ravi K. Kannadorai ◽  
Juanjuan Peng ◽  
Sidney W.-K. Yu ◽  
Young-Tae Chang ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Near Infrared ◽  
Photoacoustic Imaging ◽  
Near Infrared Dye

Naphthalene-fused BODIPY near infrared dye (Na-BD) was synthesized and used as a stable contrast agent for in vivo photoacoustic imaging.

Dual-Stimulus Responsive Near-Infrared Reversible Ratiometric Fluorescent and Photoacoustic Probe for In Vivo Tumor Imaging

2021 ◽  
Author(s):  
Xiao Liu ◽  
Xiangyang Gong ◽  
Jie Yuan ◽  
Xiaopeng Fan ◽  
Xingxing Zhang ◽  
...  
Keyword(s):  
Near Infrared ◽  
Tumor Imaging ◽  
Stimulus Responsive

scholarly journals Spectroscopically Well-Characterized RGD Optical Probe as a Prerequisite for Lifetime-Gated Tumor Imaging

2011 ◽  
Vol 10 (6) ◽  
pp. 7290.2011.00018 ◽  
Author(s):  
Julia Eva Mathejczyk ◽  
Jutta Pauli ◽  
Christian Dullin ◽  
Joanna Napp ◽  
Lutz-F. Tietze ◽  
...  
Keyword(s):  
Fluorescence Lifetime ◽  
Nude Mice ◽  
Near Infrared ◽  
Tumor Imaging ◽  
Specific Binding ◽  
Optical Probe ◽  
Detection Sensitivity ◽  
Rgd Peptides ◽  
Emissive Probes

Labeling of RGD peptides with near-infrared fluorophores yields optical probes for noninvasive imaging of tumors overexpressing αvβ3 integrins. An important prerequisite for optimum detection sensitivity in vivo is strongly absorbing and highly emissive probes with a known fluorescence lifetime. The RGD-Cy5.5 optical probe was derived by coupling Cy5.5 to a cyclic arginine–glycine–aspartic acid–d-phenylalanine–lysine (RGDfK) peptide via an aminohexanoic acid spacer. Spectroscopic properties of the probe were studied in different matrices in comparison to Cy5.5. For in vivo imaging, human glioblastoma cells were subcutaneously implanted into nude mice, and in vivo fluorescence intensity and lifetime were measured. The fluorescence quantum yield and lifetime of Cy5.5 were found to be barely affected on RGD conjugation but dramatically changed in the presence of proteins. By time domain fluorescence imaging, we demonstrated specific binding of RGD-Cy5.5 to glioblastoma xenografts in nude mice. Discrimination of unspecific fluorescence by lifetime-gated analysis further enhanced the detection sensitivity of RGD-Cy5.5-derived signals. We characterized RGD-Cy5.5 as a strongly emissive and stable probe adequate for selective targeting of αvβ3 integrins. The specificity and thus the overall detection sensitivity in vivo were optimized with lifetime gating, based on the previous determination of the probes fluorescence lifetime under application-relevant conditions.

Noninvasive and Highly Multiplexed Five-Color Tumor Imaging of Multicore Near-Infrared Resonant Surface-Enhanced Raman Nanoparticles In Vivo

ACS Nano ◽  
2021 ◽  
Author(s):  
Jung Ho Yu ◽  
Idan Steinberg ◽  
Ryan M. Davis ◽  
Andrey V. Malkovskiy ◽  
Aimen Zlitni ◽  
...  
Keyword(s):  
Near Infrared ◽  
Tumor Imaging ◽  
Surface Enhanced ◽  
Surface Enhanced Raman

scholarly journals Cypate and Cypate-Glucosamine as Near-Infrared Fluorescent Probes for In Vivo Tumor Imaging

2019 ◽  
Vol 95 (5) ◽  
pp. 475-489
Author(s):  
Mona Doshi ◽  
Daniel A. Nierenberg ◽  
Orielyz Flores-Fernandez ◽  
Pragney Deme ◽  
Edilu Becerra ◽  
...  
Keyword(s):  
Fluorescent Probes ◽  
Near Infrared ◽  
Tumor Imaging

Targeted molecular imaging of prostate cancer using tumor endothelium homing Arg-Arg-Leu peptides

2006 ◽  
Vol 24 (18_suppl) ◽  
pp. 14582-14582 ◽  
Author(s):  
D. O. Henry ◽  
S. C. Chen ◽  
M. K. Wong
Keyword(s):  
Prostate Cancer ◽  
Near Infrared ◽  
Tumor Imaging ◽  
Specific Binding ◽  
Time Lapse ◽  
Human Prostate ◽  
Animal Imaging ◽  
Tumor Endothelium ◽  
Unique Cell

14582 Background: Tumor endothelial cells express a specific and unique cell surface signature. We have previously reported on the discovery of tumor endothelial cell (TDEC) binding peptides that possess the amino acid sequence Arg-Arg-Leu (RRL). We now show specific binding of this synthetic peptide to both surgically resected and experimental human prostate adenocarcinoma tumors thereby allowing for tumor imaging. Methods and Results: Cryosections from human lung, colon, renal, breast and prostate cancers were immunohistochemically processed to reveal the relationship of RRL-peptide staining in relation to Factor VIII labeled tumor vasculature. The RRL-peptide tightly co-localizes onto tumor endothelium within human prostate adenocarcinomas, and did not stain the tumor cells proper. Alexa 680, 800 are two near-infrared dyes that can be conjugated to RRL peptide and which emit at a wavelength unquenched by biologic tissue, thus permitting whole animal imaging. Intravenous administration of RRL-peptide-Alexa chimera to human PC3 prostate tumor bearing mice or TRAMP (transgenic prostate cancer) mice results in the fluorescent visualization of tumors within the intact animal through the prolonged intra-tumor retention of the RRL-dye complex as compared to controls. Direct time-lapse intravital microscopy of such tumors show real-time tumor vascular binding of the RRL peptide. Whole animal imaging revealed the tumor and did not show an appreciable image signal at any other site or organ. Conclusion: The RRL peptide homes to prostate vasculature and is useful for the specific detection of experimental prostate tumors in vivo. Further development of the RRL-peptide into a drug delivery and imaging agent is underway. No significant financial relationships to disclose.

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