scholarly journals Enhanced antibacterial efficacy of nitric oxide releasing thermoplastic polyurethanes with antifouling hydrophilic topcoats

2017 ◽  
Vol 5 (7) ◽  
pp. 1246-1255 ◽  
Author(s):  
Priyadarshini Singha ◽  
Jitendra Pant ◽  
Marcus J. Goudie ◽  
Christina D. Workman ◽  
Hitesh Handa
Keyword(s):  
Nitric Oxide ◽  
Medical Devices ◽  
Antimicrobial Efficacy ◽  
Healthcare Associated Infections ◽  
Antibacterial Efficacy ◽  
Thermoplastic Polyurethanes ◽  
Nitric Oxide Releasing ◽  
Healthcare Associated

Hydrophilic antifouling topcoat combined with nitric oxide releasing polymer to enhance antimicrobial efficacy and combat healthcare-associated infections caused by medical devices.

scholarly journals Impact of Healthcare-Associated Infections Connected to Medical Devices—An Update

2021 ◽  
Vol 9 (11) ◽  
pp. 2332
Author(s):  
Nitin Chandra Teja Dadi ◽  
Barbora Radochová ◽  
Jarmila Vargová ◽  
Helena Bujdáková
Keyword(s):  
Medical Devices ◽  
Surgical Site Infections ◽  
Central Line ◽  
Ventilator Associated Pneumonia ◽  
Healthcare Associated Infections ◽  
Care Bundles ◽  
Planktonic Form ◽  
Novel Approaches ◽  
Healthcare Associated ◽  
The Impact

Healthcare-associated infections (HAIs) are caused by nosocomial pathogens. HAIs have an immense impact not only on developing countries but also on highly developed parts of world. They are predominantly device-associated infections that are caused by the planktonic form of microorganisms as well as those organized in biofilms. This review elucidates the impact of HAIs, focusing on device-associated infections such as central line-associated bloodstream infection including catheter infection, catheter-associated urinary tract infection, ventilator-associated pneumonia, and surgical site infections. The most relevant microorganisms are mentioned in terms of their frequency of infection on medical devices. Standard care bundles, conventional therapy, and novel approaches against device-associated infections are briefly mentioned as well. This review concisely summarizes relevant and up-to-date information on HAIs and HAI-associated microorganisms and also provides a description of several useful approaches for tackling HAIs.

A Synergistic New Approach Toward Enhanced Antibacterial Efficacy via Antimicrobial Peptide Immobilization on a Nitric Oxide-Releasing Surface

2021 ◽  
Vol 13 (37) ◽  
pp. 43892-43903
Author(s):  
Arnab Mondal ◽  
Priyadarshini Singha ◽  
Megan Douglass ◽  
Lori Estes ◽  
Mark Garren ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Antimicrobial Peptide ◽  
Antibacterial Efficacy ◽  
New Approach ◽  
Nitric Oxide Releasing

Antibacterial properties of nitric oxide-releasing porous silicon nanoparticles

2016 ◽  
Vol 4 (11) ◽  
pp. 2051-2058 ◽  
Author(s):  
M. Hasanzadeh Kafshgari ◽  
B. Delalat ◽  
F. J. Harding ◽  
A. Cavallaro ◽  
E. Mäkilä ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Porous Silicon ◽  
Silicon Nanoparticles ◽  
Antibacterial Properties ◽  
Antibacterial Efficacy ◽  
Porous Silicon Nanoparticles ◽  
Nitric Oxide Releasing

In this study, the antibacterial efficacy of NO-releasing porous silicon nanoparticles (pSiNPs) is reported. NO-releasing pSiNPs were producedviathe conjugation ofS-nitrosothiol (SNO) andS-nitrosoglutathione (GSNO) donors to the nanoparticle surfaces.

scholarly journals CouldHistoplasma capsulatumBe Related to Healthcare-Associated Infections?

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Laura Elena Carreto-Binaghi ◽  
Lisandra Serra Damasceno ◽  
Nayla de Souza Pitangui ◽  
Ana Marisa Fusco-Almeida ◽  
Maria José Soares Mendes-Giannini ◽  
...  
Keyword(s):  
Medical Devices ◽  
Histoplasma Capsulatum ◽  
Paracoccidioides Brasiliensis ◽  
Etiologic Agent ◽  
Hospital Environment ◽  
Healthcare Associated Infections ◽  
Filamentous Form ◽  
Etiologic Agents ◽  
Cross Transmission ◽  
Healthcare Associated

Healthcare-associated infections (HAI) are described in diverse settings. The main etiologic agents of HAI are bacteria (85%) and fungi (13%). Some factors increase the risk for HAI, particularly the use of medical devices; patients with severe cuts, wounds, and burns; stays in the intensive care unit, surgery, and hospital reconstruction works. Several fungal HAI are caused byCandidaspp., usually from an endogenous source; however, cross-transmission via the hands of healthcare workers or contaminated devices can occur. Although other medically important fungi, such asBlastomyces dermatitidis,Paracoccidioides brasiliensis, andHistoplasma capsulatum, have never been considered nosocomial pathogens, there are some factors that point out the pros and cons for this possibility. Among these fungi,H. capsulatuminfection has been linked to different medical devices and surgery implants. The filamentous form ofH. capsulatummay be present in hospital settings, as this fungus adapts to different types of climates and has great dispersion ability. Although conventional pathogen identification techniques have never identifiedH. capsulatumin the hospital environment, molecular biology procedures could be useful in this setting. More research onH. capsulatumas a HAI etiologic agent is needed, since it causes a severe and often fatal disease in immunocompromised patients.

Preventing Healthcare-Associated Infections by Monitoring the Cleanliness of Medical Devices and Other Critical Points in a Sterilization Service

2016 ◽  
Vol 50 (s3) ◽  
pp. 45-52 ◽  
Author(s):  
Isabel Veiga-Malta
Keyword(s):  
Medical Devices ◽  
Positive Impact ◽  
Good Practice ◽  
Surgical Instruments ◽  
Healthcare Associated Infections ◽  
Positive Contribution ◽  
Atp Bioluminescence ◽  
Sterilization Service ◽  
Healthcare Associated

Abstract It is well known that the common goal of all central sterile supply departments (CSSDs) is to prevent healthcare-associated infections. Such infections entail high costs to society, not only economic but also social. Therefore, delivering safe medical devices and guaranteeing a positive contribution to the control of healthcare-associated infections form the main responsibilities of a CSSD. The monitoring of the effectiveness of medical device cleaning processes is highly recommended. However, ensuring a flawless environment for the preparation, assembly, and packaging of medical devices and clean handling of sterilized items is crucial to achieving the goal of safe medical devices. This study analyzed not only the cleanliness of surgical instruments but also two critical aspects of the surrounding environment: the cleanliness of work surfaces and the cleanliness of workers' hands. To evaluate the cleanliness of surgical instruments, two methods were used: the adenosine triphosphate (ATP) detection method and a residual protein test. It was not the intention of this work to make an exhaustive comparison of these methods. The ATP bioluminescence method was also used for monitoring the cleanliness of work surfaces and workers' hands. The aims of this study were to establish the most suitable method of evaluating the cleanliness of reusable medical devices in the CSSD and to assess the quality of the environment. Assessing the surgical instruments, work surfaces, and staff hands for cleanliness allowed the identification of possible contamination sources and to correct them by improving cleaning/disinfection protocols. Furthermore, the use of ATP monitoring tests of workers' hands highlighted the importance of staff compliance with good practice guidelines. Thus, these results have a positive impact on the CSSD quality system and, consequently, on patient safety.

scholarly journals Healthcare-associated infections, medical devices and biofilms: risk, tolerance and control

2015 ◽  
Vol 64 (4) ◽  
pp. 323-334 ◽  
Author(s):  
Steven L. Percival ◽  
Louise Suleman ◽  
Claudia Vuotto ◽  
Gianfranco Donelli
Keyword(s):  
Medical Devices ◽  
Risk Tolerance ◽  
Healthcare Associated Infections ◽  
Healthcare Associated ◽  
And Control

Multiresistente Erreger (MRE) in der Rehabilitation: Prävalenz und Risikofaktoren für MRGN und VRE

2020 ◽  
Vol 59 (06) ◽  
pp. 366-375
Author(s):  
Katrin Steul ◽  
Cleo Schmehl ◽  
Marlene Berres ◽  
Sabine Hofmann ◽  
Andrea Klaus-Altschuck ◽  
...  
Keyword(s):  
Medical Devices ◽  
Multiresistente Erreger ◽  
Healthcare Associated Infections ◽  
Term Care ◽  
Iso 15189 ◽  
Care Facilities ◽  
Neurologische Frührehabilitation ◽  
Vitek 2 ◽  
Healthcare Associated

Zusammenfassung Hintergrund Nach einer ersten großen Untersuchung zu multiresistenten Erregern (MRE) in Rehabilitationseinrichtungen im Jahr 2014 führte das MRE-Netz Rhein-Main im Jahr 2019 erneut eine Untersuchung durch, diesmal wurde vor dem Hintergrund der KRINKO-Empfehlung zu multiresistenten Enterokokken auf das Vorkommen Vancomycin-resistenter Enterokokken (VRE) und multiresistenter gramnegative Erreger (3MRGN und 4MRGN) untersucht. Material und Methoden Insgesamt 16 Kliniken nahmen teil, darunter eine Klinik für neurologische Frührehabilitation (FR). Die Teilnahme der Patienten war freiwillig. Die Rektalabstriche wurden in einem nach DIN ISO 15189-akkreditierten medizinisch-mikrobiologischen Labor mittels etablierten Standard-Methoden (u. a. via mittels MALDI–TOF-MS und VITEK 2-Resistenztestung gem. EUCAST) analysiert. Mit dem standardisierten Fragebogen der europaweiten HALT-Untersuchung (Healthcare associated infections in long-term care facilities) wurden Patientencharakteristika (Alter, Geschlecht, Krankenhaus, OP- und MRE-Anamnese, Medical devices, aktuelle Antibiotikatherapie etc.) erhoben. Ergebnisse 928 Patienten nahmen an der Untersuchung teil, 895 aus allgemeinen Reha-Einrichtungen (AR) und 33 aus einer neurologischen Frührehabilitation (FR). 65% der AR-Patienten (FR 100%) gaben einen Klinikaufenthalt in den letzten 6 Monaten an, 29% (FR 100%) der Patienten wurden direkt aus einer Klinik aufgenommen, 22% (FR 64%) hatten eine Antibiotika-Therapie in den letzten 3 Monaten erhalten. Medical devices waren bei AR-Patienten mit 1% insgesamt selten, in der FR mit 61% Harnwegskathetern und 36% Gefäßkathetern jedoch häufig. 2,2% (FR 33,3%) der AR-Patienten waren mit VRE und 6,7% (FR 18,2%) mit 3MRGN besiedelt. Ein Patient wies einen 4MRGN-Erreger auf (FR 0). Diskussion Im Vergleich zur früheren Untersuchung ergaben sich bei den erhobenen Patientencharakteristika keine wesentlichen Änderungen. Die VRE-Prävalenz war mit 3,3% niedrig, die Prävalenz an 3MRGN war mit 7,1% im Vergleich zu 2014 (3,6%) höher. Risikofaktoren für eine VRE- und eine 3MRGN-Besiedelung (sign. erhöhte Odds-Ratio) waren: Krankenhausbehandlung in der Anamnese sowie ein erhöhter Pflegebedarf aufgrund von Bewegungseinschränkung, Stuhlinkontinenz und Desorientiertheit. Darüber hinaus wurden eine vorausgegangene Antibiotikabehandlung sowie Hautbarriereverletzungen bedingt durch Medical devices oder Wunden als weitere Risikofaktoren für eine VRE-Besiedelung gefunden.

scholarly journals Effectiveness of autoclaving in sterilizing reusable medical devices in healthcare facilities

2019 ◽  
Vol 13 (10) ◽  
pp. 858-864 ◽  
Author(s):  
Gopal Panta ◽  
Ann K Richardson ◽  
Ian C Shaw
Keyword(s):  
Developing Countries ◽  
Medical Devices ◽  
Cost Effective ◽  
Biological Indicators ◽  
Healthcare Associated Infections ◽  
Steam Sterilization ◽  
Healthcare Facilities ◽  
Clinical Procedures ◽  
Cost Effective Method ◽  
Healthcare Associated

Medical devices are sterilized before being used for invasive clinical procedures such as surgery, to prevent pathogen transfer. Failure to sterilize medical devices properly presents a risk of healthcare-associated infections. Studies and reports have indicated that inadequately sterilized medical devices are one of the causes of a higher rate of healthcare-associated infections in developing countries. Steam sterilization (autoclaving) is the most widely used method for sterilization and is considered the most robust and cost-effective method for sterilization of medical devices. The effectiveness of steam sterilization can be measured using biological indicators. A literature search was undertaken to understand the effectiveness of autoclaving in sterilizing reusable medical devices in healthcare facilities across the globe. Studies using biological indicators for measuring the effectiveness of autoclaving were obtained. Failures of steam sterilization practices were identified and discussed as a means of identifying factors that might be associated with the ineffectiveness of steam sterilization practices between different countries. The number of studies measuring the effectiveness of steam sterilization is small, and few evaluate the effectiveness of steam sterilization specifically in developing countries. There are fewer studies on higher level healthcare facilities than dental facilities. More evidence about the effectiveness of autoclaving in healthcare facilities is needed to draw firm conclusions, but the data suggest that there are inadequacies in autoclave procedures and operator education.

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