Mineral binding peptides with enhanced binding stability in serum

2017 ◽  
Vol 5 (4) ◽  
pp. 663-668
Author(s):  
Jae Sung Lee ◽  
Xiaohua Yu ◽  
Amy J. Wagoner Johnson ◽  
William L. Murphy
Keyword(s):  
Growth Factor ◽  
Calcium Phosphate ◽  
Binding Peptides ◽  
Mineral Binding

Modular growth factor peptides that bind to calcium phosphate minerals via an osteocalcin-inspired sequence show significantly enhanced binding stability in serum.

Fibroblast growth factor 23 and calcium phosphate homeostasis after pediatric renal transplantation

2012 ◽  
Vol 16 (5) ◽  
pp. 443-450 ◽  
Author(s):  
Michael van Husen ◽  
Anja Lehnhardt ◽  
Ann-Katrin Fischer ◽  
Florian Brinkert ◽  
Sebastian Loos ◽  
...  
Keyword(s):  
Renal Transplantation ◽  
Growth Factor ◽  
Calcium Phosphate ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor 23 ◽  
Fibroblast Growth ◽  
Pediatric Renal Transplantation ◽  
Phosphate Homeostasis

Bone Regenerative Properties of Injectable Calcium Phosphate/PLGA Cement in an Alveolar Bone Defect

2012 ◽  
Vol 529-530 ◽  
pp. 300-303 ◽  
Author(s):  
R.P. Félix Lanao ◽  
J.W.M. Hoekstra ◽  
Joop G.C. Wolke ◽  
Sander C.G. Leeuwenburgh ◽  
A.S. Plachokova ◽  
...  
Keyword(s):  
Growth Factors ◽  
Growth Factor ◽  
Calcium Phosphate ◽  
Bone Formation ◽  
Bone Substitute ◽  
Alveolar Bone ◽  
Bone Defects ◽  
Plga Microspheres ◽  
Bone Substitute Material ◽  
Substitute Material

Periodontitis is one of the most common inflammatory diseases, which can lead to early tooth loss. The conventional treatment of periodontitis is to arrest the disease progression. Most reconstructive procedures involve application of bone substitutes, barrier membranes or a combination of both into the bony defects. Calcium phosphate cements (CPCs) are the predominant type of bone substitute material used for reasons of injectability and hence perfect filling potential for bone defects. Recently, injectable apatitic CPCs demonstrated to be more rapidly degradable when combined with poly (lactic-co-glycolic) acid (PLGA) microspheres. Further, PLGA microspheres can be used as a delivery vehicle for growth factors. In this study, the performance of injectable CPCs as a bone substitute material for alveolar bone defects created in Beagle dogs was evaluated. Four CPC-formulations were generated by incorporating hollow or dense PLGA microspheres, either or not loaded with the growth factors (platelet derived growth factor (PDGF) and insulin-like growth factor (IGF). Implantation period was 8 weeks. Bone formation was based on histological and histomorphometrical evaluation. The results demonstrated that filling alveolar bone defects with CPC-dense PLGA revealed significant more bone formation compared to CPC-hollow PLGA either or not loaded with IGF and PDGF. In summary, we conclude that injectable CPC-dense PLGA composites proved to be the most suitable material for a potential use as off the shelf material due to its good biocompatibility, enhanced degradability and subsequent bone formation.

Transforming Growth Factor-?1 Release from a Porous Electrostatic Spray Deposition?Derived Calcium Phosphate Coating

2006 ◽  
Vol 0 (0) ◽  
pp. 060913044658029
Author(s):  
Marijke C. Siebers ◽  
X. Frank Walboomers ◽  
Sander C.G. Leewenburgh ◽  
Joop C.G. Wolke ◽  
Otto C. Boerman ◽  
...  
Keyword(s):  
Growth Factor ◽  
Calcium Phosphate ◽  
Transforming Growth Factor ◽  
Spray Deposition ◽  
Calcium Phosphate Coating ◽  
Phosphate Coating ◽  
Electrostatic Spray Deposition ◽  
Electrostatic Spray

scholarly journals Peptide–Mineral Complexes: Understanding Their Chemical Interactions, Bioavailability, and Potential Application in Mitigating Micronutrient Deficiency

Foods ◽  
2020 ◽  
Vol 9 (10) ◽  
pp. 1402
Author(s):  
Xiaohong Sun ◽  
Roghayeh Amini Sarteshnizi ◽  
Ruth T. Boachie ◽  
Ogadimma D. Okagu ◽  
Raliat O. Abioye ◽  
...  
Keyword(s):  
Micronutrient Deficiency ◽  
Health Concern ◽  
Future Research ◽  
Food Protein ◽  
Chemical Interactions ◽  
Food Ingredients ◽  
Binding Peptides ◽  
Mineral Binding ◽  
Micronutrient Fortification ◽  
Relationship Of

Iron, zinc, and calcium are essential micronutrients that play vital biological roles to maintain human health. Thus, their deficiencies are a public health concern worldwide. Mitigation of these deficiencies involves micronutrient fortification of staple foods, a strategy that can alter the physical and sensory properties of foods. Peptide–mineral complexes have been identified as promising alternatives for mineral-fortified functional foods or mineral supplements. This review outlines some of the methods used in the determination of the mineral chelating activities of food protein-derived peptides and the approaches for the preparation, purification and identification of mineral-binding peptides. The structure–activity relationship of mineral-binding peptides and the potential use of peptide–mineral complexes as functional food ingredients to mitigate micronutrient deficiency are discussed in relation to their chemical interactions, solubility, gastrointestinal digestion, absorption, and bioavailability. Finally, insights on the current challenges and future research directions in this area are provided.

Regulation of in vitro Calcium Phosphate Mineralization by Combinatorially Selected Hydroxyapatite-Binding Peptides

2008 ◽  
Vol 9 (3) ◽  
pp. 966-973 ◽  
Author(s):  
Mustafa Gungormus ◽  
Hanson Fong ◽  
Il Won Kim ◽  
John Spencer Evans ◽  
Candan Tamerler ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Phosphate Mineralization ◽  
Binding Peptides

Transforming Growth Factor-β1 Release from a Porous Electrostatic Spray Deposition–Derived Calcium Phosphate Coating

2006 ◽  
Vol 12 (9) ◽  
pp. 2449-2456 ◽  
Author(s):  
Marijke C. Siebers ◽  
X. Frank Walboomers ◽  
Sander C.G. Leewenburgh ◽  
Joop C.G. Wolke ◽  
Otto C. Boerman ◽  
...  
Keyword(s):  
Growth Factor ◽  
Calcium Phosphate ◽  
Transforming Growth Factor ◽  
Spray Deposition ◽  
Transforming Growth Factor Β1 ◽  
Calcium Phosphate Coating ◽  
Phosphate Coating ◽  
Electrostatic Spray Deposition ◽  
Electrostatic Spray

Design and Fabrication of Complex Scaffolds for Bone Defect Healing: Combined 3D Plotting of a Calcium Phosphate Cement and a Growth Factor-Loaded Hydrogel

2016 ◽  
Vol 45 (1) ◽  
pp. 224-236 ◽  
Author(s):  
Tilman Ahlfeld ◽  
Ashwini Rahul Akkineni ◽  
Yvonne Förster ◽  
Tino Köhler ◽  
Sven Knaack ◽  
...  
Keyword(s):  
Growth Factor ◽  
Calcium Phosphate ◽  
Bone Defect ◽  
Calcium Phosphate Cement ◽  
Defect Healing ◽  
Bone Defect Healing
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