Transforming Growth Factor-β1 Release from a Porous Electrostatic Spray Deposition–Derived Calcium Phosphate Coating

2006 ◽  
Vol 12 (9) ◽  
pp. 2449-2456 ◽  
Author(s):  
Marijke C. Siebers ◽  
X. Frank Walboomers ◽  
Sander C.G. Leewenburgh ◽  
Joop C.G. Wolke ◽  
Otto C. Boerman ◽  
...  
Keyword(s):  
Growth Factor ◽  
Calcium Phosphate ◽  
Transforming Growth Factor ◽  
Spray Deposition ◽  
Transforming Growth Factor Β1 ◽  
Calcium Phosphate Coating ◽  
Phosphate Coating ◽  
Electrostatic Spray Deposition ◽  
Electrostatic Spray

Transforming Growth Factor-?1 Release from a Porous Electrostatic Spray Deposition?Derived Calcium Phosphate Coating

2006 ◽  
Vol 0 (0) ◽  
pp. 060913044658029
Author(s):  
Marijke C. Siebers ◽  
X. Frank Walboomers ◽  
Sander C.G. Leewenburgh ◽  
Joop C.G. Wolke ◽  
Otto C. Boerman ◽  
...  
Keyword(s):  
Growth Factor ◽  
Calcium Phosphate ◽  
Transforming Growth Factor ◽  
Spray Deposition ◽  
Calcium Phosphate Coating ◽  
Phosphate Coating ◽  
Electrostatic Spray Deposition ◽  
Electrostatic Spray

Correlating Electrospray Characteristics with Surface Morphology of Calcium Phosphate Coatings Deposited Using Electrostatic Spray Deposition (ESD)

2006 ◽  
Vol 309-311 ◽  
pp. 611-614
Author(s):  
Sander C.G. Leeuwenburgh ◽  
M.C. Heine ◽  
Joop G.C. Wolke ◽  
Sotiris E. Pratsinis ◽  
J. Schoonman ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Spray Deposition ◽  
Morphological Characteristics ◽  
Precursor Solution ◽  
Processing Parameters ◽  
Nozzle Geometry ◽  
Electrostatic Spray Deposition ◽  
Droplet Sizes ◽  
Calcium Phosphate Coatings ◽  
Electrostatic Spray

In situ measurements of electrospray droplet sizes and velocities were performed by Phase Doppler Anemometry during Electrostatic Spray Deposition (ESD) of calcium phosphate (CaP) coatings. Numerous processing parameters were varied (nozzle-to-substrate distance, deposition temperature, nozzle geometry, and composition of the precursor solution), whereafter the morphological characteristics of these ESD-derived CaP coatings were correlated with measured droplet characteristics. Equal droplet sizes and velocities were measured for nozzle-to-substrate distances up to 40 mm and deposition temperatures up to 400 °C, indicating that electrospray droplets did not shrink at all during droplet flight using an involatile solvent butyl carbitol with a high boiling point (Tb = 231 °C). Nevertheless, coatings with considerably different surface morphologies were obtained under these conditions, varying from microporous structures with coalesced pore walls to morphologies revealing isolated rings on top of dense or grainy underlayers. The chemical composition of the precursor solutions and the mixing characteristics of the calcium and phosphate precursor components strongly influenced the initial droplet sizes, precipitation kinetics of the CaP solute, and subsequent coating morphology. Unique, reticular coating morphologies were deposited at a deposition rate of 3.2 µm/hour, which have a graded structure consisting of a dense underlayer, a submicron-porous intermediate layer, and a roughened toplayer revealing droplet-derived features such as isolated rings or coalesced, hollow surface pits.

Chemical and Morphological Properties of Calcium Phosphate Coatings Deposited Using the Electrostatic Spray Deposition (ESD) Technique

2005 ◽  
Vol 284-286 ◽  
pp. 199-202 ◽  
Author(s):  
Sander C.G. Leeuwenburgh ◽  
Joop G.C. Wolke ◽  
J. Schoonman ◽  
John A. Jansen
Keyword(s):  
Calcium Phosphate ◽  
Spray Deposition ◽  
Chemical Properties ◽  
Oxide Coating ◽  
Morphological Properties ◽  
Carbonate Apatite ◽  
Electrostatic Spray Deposition ◽  
Deposition Parameters ◽  
Wide Range ◽  
Electrostatic Spray

The recently developed Electrostatic Spray Deposition (ESD) technique was used in order to deposit calcium phosphate (CaP) coatings onto various substrates, since this technique enables deposition of inorganic thin films with a variety of morphological and chemical properties. In the present study, the relationship between various deposition parameters and the physicochemical properties of deposited coatings was investigated in order to be able to deposit CaP coatings with defined chemical and morphological properties using ESD. The results showed that the chemical characteristics of the coatings were determined by both the composition of the precursor solutions (solution acidity, absolute and relative precursor concentrations) and apparatus-related parameters, such as the liquid flow rate and the nozzle-tosubstrate distance. By varying these parameters, several crystal phases and phase mixtures were obtained (carbonate apatite, carbonated hydroxyapatite, a/b-tricalciumphosphate, monetite, b/g-pyrophosphate, metaphosphate, calcite/calcium oxide). Coating morphology was also shown to be strongly dependent on several deposition parameters. A wide range of coating morphologies was obtained, varying from relatively dense to highly porous, reticular coating surface architectures.

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