scholarly journals Calcium phosphate ceramic systems in growth factor and drug delivery for bone tissue engineering: A review

2012 ◽  
Vol 8 (4) ◽  
pp. 1401-1421 ◽  
Author(s):  
Susmita Bose ◽  
Solaiman Tarafder
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Growth Factor ◽  
Calcium Phosphate ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Calcium Phosphate Ceramic

Fully Interconnected Globular Porous Biphasic Calcium Phosphate Ceramic Scaffold Facilitates Osteogenic Repair

2007 ◽  
Vol 361-363 ◽  
pp. 119-122 ◽  
Author(s):  
J.H. Lim ◽  
J.H. Park ◽  
Eui Kyun Park ◽  
Hae Jung Kim ◽  
Il Kyu Park ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Calcium Phosphate ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Bone Substitute ◽  
Biphasic Calcium Phosphate ◽  
Bone Defects ◽  
Calcium Phosphate Ceramic ◽  
Ceramic Scaffold ◽  
Porous Biphasic Calcium Phosphate

An appropriate scaffold, which provides structural support for transplanted cells and acts as a vehicle for the delivery of biologically active molecules, is critical for tissue engineering. We developed a fully interconnected globular porous biphasic calcium phosphate ceramic scaffold by adopting a foaming method, and evaluated its efficiency as a bone substitute and a scaffold for bone tissue engineering by in vitro and in vivo biocompatible analysis and its osteogenic healing capacity in rat tibial bone defects. They have spherical pores averaging 400um in diameter and interconnecting interpores averaging 70um in diameter with average 85% porosity. They elicited no cytotoxicity and noxious effect on cellular proliferation and osteoblastic differentiation during the cell-scaffold construct formation. Also the bone defects grafted with fully interconnected globular porous biphasic calcium phosphate ceramic blocks revealed excellent bone healing within 3 weeks. These findings suggest that the fully interconnected porous biphasic calcium phosphate scaffold formed by the foaming method can be a promising bone substitute and a scaffold for bone tissue engineering.

The Application of Energetic SHS Reactions in the Synthesis of Multi-functional Bone Tissue Engineering and Drug Delivery Systems

2005 ◽  
Vol 896 ◽  
Author(s):  
Reed Ayers ◽  
Doug Burkes ◽  
Guglielmo Gottoli ◽  
H.C. Yi ◽  
Jaque Guigné ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Calcium Phosphate ◽  
Bone Tissue Engineering ◽  
Combustion Synthesis ◽  
Bone Tissue ◽  
Drug Delivery Systems ◽  
Exothermic Reaction ◽  
Functional Materials ◽  
Delivery Systems

AbstractThe term combustion synthesis, or self-propagating high temperature synthesis (SHS), refers to an exothermic chemical reaction process that utilizes the heat generated by the exothermic reaction to ignite and sustain a propagating combustion wave through the reactants to produce the desired product(s). The products of combustion synthesis normally are extremely porous: typically 50 percent of theoretical densityAdvantages of combustion synthesis over traditional processing routes, e.g., sintering, in the production of advanced materials such as ceramics, intermetallic compounds and composites include process economics, simplicity of operation, and low energy requirements. However, the high exothermicity and rapid combustion propagation rates necessitate a high degree of control of these reactions.One research area being conducted in the Institute for Space Resources (ISR) at the Colorado School of Mines (CSM) is the application of combustion synthesis (SHS) to synthesize advanced, engineered porous multiphase/heterogeneous calcium phosphate (HCaP), NiTi, NiTi-TiC, TiB-Ti, TiC-Ti for bone tissue engineering and drug delivery systems. Such material systems require a complex combination of properties that can be truly classified as multi-functional materials. The range of properties includes: an overall porosity of 40-60% with a pore size of 200-500 μm; mechanical properties (compression strength and Young’s modulus) that match those of natural bone to avoid ‘stress shielding’; and a surface chemistry that is capable of facilitating bone growth and mineralization.The paper will discuss the synthesis of porous multiphase/heterogeneous calcium phosphate (HCaP), NiTi, NiTi-TiC, TiB-Ti, TiC-Ti for bone tissue engineering and drug delivery systems.

scholarly journals Mesoporous bioactive glasses: structure characteristics, drug/growth factor delivery and bone regeneration application

2012 ◽  
Vol 2 (3) ◽  
pp. 292-306 ◽  
Author(s):  
Chengtie Wu ◽  
Jiang Chang
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Growth Factor ◽  
Bone Tissue Engineering ◽  
Bone Regeneration ◽  
Bone Tissue ◽  
Growth Factor Delivery ◽  
Bioactive Glasses ◽  
The Past

The impact of bone diseases and trauma in the whole world has increased significantly in the past decades. Bioactive glasses are regarded as an important bone regeneration material owing to their generally excellent osteoconductivity and osteostimulativity. A new class of bioactive glass, referred to as mesoporous bioglass (MBG), was developed 7 years ago, which possess a highly ordered mesoporous channel structure and a highly specific surface area. The study of MBG for drug/growth factor delivery and bone tissue engineering has grown significantly in the past several years. In this article, we review the recent advances of MBG materials, including the preparation of different forms of MBG, composition–structure relationship, efficient drug/growth factor delivery and bone tissue engineering application. By summarizing our recent research, the interaction of MBG scaffolds with bone-forming cells, the effect of drug/growth factor delivery on proliferation and differentiation of tissue cells and the in vivo osteogenesis of MBG scaffolds are highlighted. The advantages and limitations of MBG for drug delivery and bone tissue engineering have been compared with microsize bioactive glasses and nanosize bioactive glasses. The future perspective of MBG is discussed for bone regeneration application by combining drug delivery with bone tissue engineering and investigating the in vivo osteogenesis mechanism in large animal models.

Trends in Development of Bioresorbable Calcium Phosphate Ceramic Materials for Bone Tissue Engineering

2018 ◽  
Vol 11 (4) ◽  
pp. 419-422 ◽  
Author(s):  
M. A. Goldberg ◽  
V. V. Smirnov ◽  
A. Yu. Teterina ◽  
S. M. Barinov ◽  
V. S. Komlev
Keyword(s):  
Tissue Engineering ◽  
Calcium Phosphate ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Ceramic Materials ◽  
Calcium Phosphate Ceramic

scholarly journals 3D Printing of Calcium Phosphate Ceramics for Bone Tissue Engineering and Drug Delivery

2016 ◽  
Vol 45 (1) ◽  
pp. 23-44 ◽  
Author(s):  
Ryan Trombetta ◽  
Jason A. Inzana ◽  
Edward M. Schwarz ◽  
Stephen L. Kates ◽  
Hani A. Awad
Keyword(s):  
Drug Delivery ◽  
Tissue Engineering ◽  
Calcium Phosphate ◽  
3D Printing ◽  
Bone Tissue Engineering ◽  
Bone Tissue ◽  
Calcium Phosphate Ceramics
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