Temperature-responsive in situ nanoparticle hydrogels based on hydrophilic pendant cyclic ether modified PEG-PCL-PEG

2016 ◽  
Vol 4 (10) ◽  
pp. 1493-1502 ◽  
Author(s):  
Zujian Feng ◽  
Junqiang Zhao ◽  
Yin Li ◽  
Shuxin Xu ◽  
Junhui Zhou ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Drug Release ◽  
Ethylene Glycol ◽  
Cyclic Ether ◽  
Poly Ethylene Glycol ◽  
Sustained Drug Release ◽  
Injectable Hydrogels ◽  
Temperature Responsive ◽  
Poly Ethylene

Thermo-sensitive injectable hydrogels based on poly(ε-caprolactone)/poly(ethylene glycol) (PCL/PEG) block copolymers have attracted considerable attention for sustained drug release and tissue engineering applications.

scholarly journals Polypeptides Micelles Composed of Methoxy-Poly(Ethylene Glycol)-Poly(l-Glutamic Acid)-Poly(l-Phenylalanine) Triblock Polymer for Sustained Drug Delivery

Pharmaceutics ◽  
2018 ◽  
Vol 10 (4) ◽  
pp. 230 ◽  
Author(s):  
Xingzheng Liu ◽  
Rongrong Fan ◽  
Boting Lu ◽  
Yuan Le
Keyword(s):  
Drug Release ◽  
Ethylene Glycol ◽  
Glutamic Acid ◽  
Drug Carrier ◽  
Drug Loading ◽  
Poly Ethylene Glycol ◽  
Sustained Drug Release ◽  
Poly Ethylene ◽  
Triblock Polymers

Methoxy-poly(ethylene glycol)-poly(l-glutamic acid)-poly(l-phenylalanine) triblock polymers with different architecture were synthesized as drug carrier to obtain sustained and controlled release by tuning the composition. These triblock polymers were prepared by ring opening polymerization and poly(ethylene glycol) was used as an initiator. Polymerization was confirmed by 1H NMR, FT-IR and gel penetration chromatography. The polymers can self-assemble to form micelles in aqueous medium and their critical micelle concentrations values were examined. The micelles were spherical shape with size of 50–100 nm and especially can arranged in a regular manner. Sorafenib was selected as the model drug and the drug loading performance was dependent on the composition of the block copolymer. In vitro drug release indicated that the polymers can realize controlled and sustained drug release. Furthermore, in vitro cytotoxicity assay showed that the polymers were biocompatible and the drug-loaded micelles can increase toxicity towards tumor cells. Confocal fluorescence microscopy assays illustrated that the micelles can be uptaken quickly and release drug persistently to inhibit tumor cell growth.

Injectable hydrogels based on poly(ethylene glycol) and derivatives as functional biomaterials

RSC Advances ◽  
2015 ◽  
Vol 5 (45) ◽  
pp. 35469-35486 ◽  
Author(s):  
Emilia Bakaic ◽  
Niels M. B. Smeets ◽  
Todd Hoare
Keyword(s):  
Ethylene Glycol ◽  
Recent Progress ◽  
Design Criteria ◽  
Poly Ethylene Glycol ◽  
Injectable Hydrogels ◽  
Glycol Methacrylate ◽  
Oligoethylene Glycol ◽  
Poly Ethylene ◽  
Functional Biomaterials

The design criteria for injectable, in situ-gelling hydrogels are reviewed in conjunction with highlights on recent progress in the preparation of injectable PEG and PEG-analogue poly(oligoethylene glycol methacrylate) (POEGMA) hydrogels.

scholarly journals In situ-forming robust chitosan-poly(ethylene glycol) hydrogels prepared by copper-free azide–alkyne click reaction for tissue engineering

2014 ◽  
Vol 2 (2) ◽  
pp. 167-175 ◽  
Author(s):  
Vinh X. Truong ◽  
Matthew P. Ablett ◽  
Hamish T. J. Gilbert ◽  
James Bowen ◽  
Stephen M. Richardson ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Ethylene Glycol ◽  
Click Reaction ◽  
Poly Ethylene Glycol ◽  
In Situ Forming ◽  
Poly Ethylene

scholarly journals Three-Dimensional Microassembly of Cell-Laden Microplates by in situ Gluing with Photocurable Hydrogels

2014 ◽  
Vol 8 (1) ◽  
pp. 95-101 ◽  
Author(s):  
Shotaro Yoshida ◽  
◽  
Koji Sato ◽  
Shoji Takeuchi
Keyword(s):  
Tissue Engineering ◽  
Ethylene Glycol ◽  
Interaction Analysis ◽  
Three Dimensional ◽  
Cell Interaction ◽  
Poly Ethylene Glycol ◽  
Peg Hydrogels ◽  
Assembly Method ◽  
Poly Ethylene

This paper describes a method for assembling cellladen microplates into three-dimensional (3D) microstructures by in situ gluing using photocurable hydrogels. We picked up cell-laden microplates with microtweezers, placed the plate perpendicular to one another on a microgroove device, and glued them by local photopolymerization of biocompatible Poly (Ethylene Glycol) (PEG) hydrogels. The advantage of this assembly method is its ability to construct 3D biological microstructures with targeted cells. We demonstrated the assembly of a 3D half-cube microstructure with genetically labeled cell-laden microplates. We believe our method is useful for engineering the positions of cells in 3D configurations for cell-cell interaction analysis and tissue engineering.

Biocompatible degradable injectable hydrogels from methacrylated poly(ethylene glycol)-co-poly(xylitol sebacate) and cyclodextrins for release of hydrophilic and hydrophobic drugs

RSC Advances ◽  
2015 ◽  
Vol 5 (82) ◽  
pp. 66965-66974 ◽  
Author(s):  
Mengyao Zhang ◽  
Yaobin Wu ◽  
Xin Zhao ◽  
Kun Gao ◽  
Peter X. Ma ◽  
...  
Keyword(s):  
Drug Release ◽  
Ethylene Glycol ◽  
Composite Hydrogel ◽  
Hydrophobic Drugs ◽  
Hydrophobic Drug ◽  
Poly Ethylene Glycol ◽  
Injectable Hydrogels ◽  
Poly Ethylene

An injectable photocurable composite hydrogel from methacrylated poly(ethylene glycol)-co-poly(xylitol sebacate) (PEGXS-M) and acrylamidomethyl-β-cyclodextrin (β-CD-NMA) for both hydrophilic and hydrophobic drug release.

scholarly journals Poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) Copolymers for the Formulation of In Situ Forming Depot Long-Acting Injectables

Pharmaceutics ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 605
Author(s):  
Marie-Emérentienne Cagnon ◽  
Silvio Curia ◽  
Juliette Serindoux ◽  
Jean-Manuel Cros ◽  
Feifei Ng ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Surface Erosion ◽  
Sustained Delivery ◽  
Trimethylene Carbonate ◽  
Poly Ethylene Glycol ◽  
In Situ Forming ◽  
Poly Ethylene ◽  
Long Acting

This article describes the utilization of (methoxy)poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) ((m)PEG–PTMC) diblock and triblock copolymers for the formulation of in situ forming depot long-acting injectables by solvent exchange. The results shown in this manuscript demonstrate that it is possible to achieve long-term drug deliveries from suspension formulations prepared with these copolymers, with release durations up to several months in vitro. The utilization of copolymers with different PEG and PTMC molecular weights affords to modulate the release profile and duration. A pharmacokinetic study in rats with meloxicam confirmed the feasibility of achieving at least 28 days of sustained delivery by using this technology while showing good local tolerability in the subcutaneous environment. The characterization of the depots at the end of the in vivo study suggests that the rapid phase exchange upon administration and the surface erosion of the resulting depots are driving the delivery kinetics from suspension formulations. Due to the widely accepted utilization of meloxicam as an analgesic drug for animal care, the results shown in this article are of special interest for the development of veterinary products aiming at a very long-term sustained delivery of this therapeutic molecule.

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