Injectable hydrogels based on poly(ethylene glycol) and derivatives as functional biomaterials

RSC Advances ◽  
2015 ◽  
Vol 5 (45) ◽  
pp. 35469-35486 ◽  
Author(s):  
Emilia Bakaic ◽  
Niels M. B. Smeets ◽  
Todd Hoare
Keyword(s):  
Ethylene Glycol ◽  
Recent Progress ◽  
Design Criteria ◽  
Poly Ethylene Glycol ◽  
Injectable Hydrogels ◽  
Glycol Methacrylate ◽  
Oligoethylene Glycol ◽  
Poly Ethylene ◽  
Functional Biomaterials

The design criteria for injectable, in situ-gelling hydrogels are reviewed in conjunction with highlights on recent progress in the preparation of injectable PEG and PEG-analogue poly(oligoethylene glycol methacrylate) (POEGMA) hydrogels.

Injectable and tunable poly(ethylene glycol) analogue hydrogels based on poly(oligoethylene glycol methacrylate)

2014 ◽  
Vol 50 (25) ◽  
pp. 3306 ◽  
Author(s):  
Niels M. B. Smeets ◽  
Emilia Bakaic ◽  
Mathew Patenaude ◽  
Todd Hoare
Keyword(s):  
Ethylene Glycol ◽  
Poly Ethylene Glycol ◽  
Glycol Methacrylate ◽  
Oligoethylene Glycol ◽  
Poly Ethylene

Temperature-responsive in situ nanoparticle hydrogels based on hydrophilic pendant cyclic ether modified PEG-PCL-PEG

2016 ◽  
Vol 4 (10) ◽  
pp. 1493-1502 ◽  
Author(s):  
Zujian Feng ◽  
Junqiang Zhao ◽  
Yin Li ◽  
Shuxin Xu ◽  
Junhui Zhou ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Drug Release ◽  
Ethylene Glycol ◽  
Cyclic Ether ◽  
Poly Ethylene Glycol ◽  
Sustained Drug Release ◽  
Injectable Hydrogels ◽  
Temperature Responsive ◽  
Poly Ethylene

Thermo-sensitive injectable hydrogels based on poly(ε-caprolactone)/poly(ethylene glycol) (PCL/PEG) block copolymers have attracted considerable attention for sustained drug release and tissue engineering applications.

scholarly journals Poly(ethylene glycol) brush-b-poly(N-vinylpyrrolidone)-based double hydrophilic block copolymer particles crosslinked via crystalline α-cyclodextrin domains

RSC Advances ◽  
2019 ◽  
Vol 9 (9) ◽  
pp. 4993-5001 ◽  
Author(s):  
Noah Al Nakeeb ◽  
Zdravko Kochovski ◽  
Tingting Li ◽  
Youjia Zhang ◽  
Yan Lu ◽  
...  
Keyword(s):  
Block Copolymer ◽  
Ethylene Glycol ◽  
Self Assembly ◽  
Poly Ethylene Glycol ◽  
Glycol Methacrylate ◽  
Oligoethylene Glycol ◽  
Poly Ethylene ◽  
Copolymer Poly

Self-assembly of the double hydrophilic block copolymer poly(N-vinylpyrrolidone)-b-poly(oligoethylene glycol methacrylate) and supramolecular crosslinking via α-cyclodextrin in water is presented.

scholarly journals Poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) Copolymers for the Formulation of In Situ Forming Depot Long-Acting Injectables

Pharmaceutics ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 605
Author(s):  
Marie-Emérentienne Cagnon ◽  
Silvio Curia ◽  
Juliette Serindoux ◽  
Jean-Manuel Cros ◽  
Feifei Ng ◽  
...  
Keyword(s):  
Ethylene Glycol ◽  
Surface Erosion ◽  
Sustained Delivery ◽  
Trimethylene Carbonate ◽  
Poly Ethylene Glycol ◽  
In Situ Forming ◽  
Poly Ethylene ◽  
Long Acting

This article describes the utilization of (methoxy)poly(ethylene glycol)-b-poly(1,3-trimethylene carbonate) ((m)PEG–PTMC) diblock and triblock copolymers for the formulation of in situ forming depot long-acting injectables by solvent exchange. The results shown in this manuscript demonstrate that it is possible to achieve long-term drug deliveries from suspension formulations prepared with these copolymers, with release durations up to several months in vitro. The utilization of copolymers with different PEG and PTMC molecular weights affords to modulate the release profile and duration. A pharmacokinetic study in rats with meloxicam confirmed the feasibility of achieving at least 28 days of sustained delivery by using this technology while showing good local tolerability in the subcutaneous environment. The characterization of the depots at the end of the in vivo study suggests that the rapid phase exchange upon administration and the surface erosion of the resulting depots are driving the delivery kinetics from suspension formulations. Due to the widely accepted utilization of meloxicam as an analgesic drug for animal care, the results shown in this article are of special interest for the development of veterinary products aiming at a very long-term sustained delivery of this therapeutic molecule.

Nanocomposite polymer electrolytes based on poly(poly(ethylene glycol)methacrylate), MMT or ZSM-5 formulated with LiTFSI and PYR11TFSI for Li-ion batteries

RSC Advances ◽  
2016 ◽  
Vol 6 (9) ◽  
pp. 7249-7259 ◽  
Author(s):  
J. Cardoso ◽  
A. Mayrén ◽  
I. C. Romero-Ibarra ◽  
D. P. Nava ◽  
J. Vazquez-Arenas
Keyword(s):  
Ethylene Glycol ◽  
Polymer Electrolytes ◽  
Li Ion Batteries ◽  
Poly Ethylene Glycol ◽  
Glycol Methacrylate ◽  
Nanocomposite Polymer ◽  
Li Ion ◽  
Nanocomposite Electrolytes ◽  
Poly Ethylene ◽  
Nanocomposite Polymer Electrolytes

Novel poly(poly(ethylenglycol)methacrylate) nanocomposite electrolytes based on montmorillonite and zeolite; and functionalized with LiTFSI and PYR11TFSI are synthetized for Li-ion batteries.

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