Monitoring in vitro neural stem cell differentiation based on surface-enhanced Raman spectroscopy using a gold nanostar array

2015 ◽  
Vol 3 (16) ◽  
pp. 3848-3859 ◽  
Author(s):  
Waleed Ahmed El-Said ◽  
Seung U. Kim ◽  
Jeong-Woo Choi
Keyword(s):  
Stem Cell ◽  
Neural Stem Cell ◽  
Stem Cell Differentiation ◽  
Surface Enhanced Raman Spectroscopy ◽  
Invasive Monitoring ◽  
Non Invasive ◽  
Cell Chip ◽  
Surface Enhanced ◽  
Surface Enhanced Raman

Neuro-cell chip was developed for non-invasive monitoring of neural stem cell stimulation using SERS technique that enabled the real-time monitoring, which is important for tissue development protocols.

scholarly journals Surface-Enhanced Raman Spectroscopy for Cancer Immunotherapy Applications: Opportunities, Challenges, and Current Progress in Nanomaterial Strategies

Nanomaterials ◽  
2020 ◽  
Vol 10 (6) ◽  
pp. 1145 ◽  
Author(s):  
Shuvashis Dey ◽  
Matt Trau ◽  
Kevin M. Koo
Keyword(s):  
Raman Spectroscopy ◽  
Cancer Immunotherapy ◽  
Immune Checkpoint ◽  
Checkpoint Inhibitors ◽  
Surface Enhanced Raman Spectroscopy ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Checkpoint Receptors

Cancer immunotherapy encompasses a variety of approaches which target or use a patient’s immune system components to eliminate cancer. Notably, the current use of immune checkpoint inhibitors to target immune checkpoint receptors such as CTLA-4 or PD-1 has led to remarkable treatment responses in a variety of cancers. To predict cancer patients’ immunotherapy responses effectively and efficiently, multiplexed immunoassays have been shown to be advantageous in sensing multiple immunomarkers of the tumor microenvironment simultaneously for patient stratification. Surface-enhanced Raman spectroscopy (SERS) is well-regarded for its capabilities in multiplexed bioassays and has been increasingly demonstrated in cancer immunotherapy applications in recent years. This review focuses on SERS-active nanomaterials in the modern literature which have shown promise for enabling cancer patient-tailored immunotherapies, including multiplexed in vitro and in vivo immunomarker sensing and imaging, as well as immunotherapy drug screening and delivery.

Non-invasive diagnosis of Crohn's disease based on SERS combined with PCA-SVM

2021 ◽  
Author(s):  
Bingyan Li ◽  
Yaling Wu ◽  
Zijie Wang ◽  
Mengmeng Xing ◽  
Weimin Xu ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Surface Enhanced Raman Spectroscopy ◽  
Metabolic Change ◽  
Healthy Controls ◽  
Non Invasive ◽  
Surface Enhanced ◽  
Surface Enhanced Raman

The metabolic change of patients (Crohn's disease (CD)/active CD (aCD)/inactive CD (iCD)) and healthy controls (HC) could be identified by measuring urine with surface-enhanced Raman spectroscopy (SERS).

scholarly journals Subpicosecond dynamics in DNA from leaves ofin vitro-grown apple plants: A SERS study

2011 ◽  
Vol 26 (1) ◽  
pp. 59-68 ◽  
Author(s):  
Cristina M. Muntean ◽  
Ioan Bratu ◽  
Nicolae Leopold ◽  
Monica A. P. Purcaru
Keyword(s):  
Surface Enhanced Raman Spectroscopy ◽  
Metallic Surface ◽  
Relaxation Processes ◽  
Molecular Subgroups ◽  
Molecular Subgroup ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Leaf Tissues ◽  
Genomic Dnas

In this work the SERS total half bandwidths of five genomic DNAs fromin vitro-grown apple leaf tissues (Malus domesticaBorkh., FamRosaceae, cvs. Florina, Rebra, Goldrush, Romus 3 and Romus 4) have been measured. We have shown that surface-enhanced Raman scattering can be used to study the fast subpicosecond dynamics of DNA in the proximity of a metallic surface. The dependencies of the total half bandwidths and of the global relaxation times, on DNA molecular subgroup structure, on the type of genomic apple plant DNA and on time, are reported. An example of the time-dependence of SERS band parameters of DNA, in the proximity of silver nanoparticles, has been given. It is shown that changes in the subpicosecond surface dynamics of molecular subgroups in genomic DNAs fromin vitro-grown apple leaf tissues can be monitored with surface-enhanced Raman spectroscopy. Particularly, the SERS band parameters for the vibrations near 757 cm–1(dT), 773 cm–1(dC), 929 cm–1(deoxyribose), 1087 cm–1(PO2–symmetric stretch, backbone), 1127 cm–1(dA), 1181 cm–1(ring vibrations of dG, dT, dC), 1311 cm–1(dA), 1362 cm–1(dT, dA), 1510 cm–1(dA), 1573 cm–1(dG, dA) and 1650 cm–1[dT(C═O), δ(H2O)] of genomic DNAs from apple leaves are presented. In our study, the full widths at half-maximum (FWHM) of the bands in genomic DNAs fromin vitro-grown apple leaf tissues are typically in the wavenumber range from 14 to 52 cm–1. Besides, it can be observed that molecular relaxation processes studied in this work, have a global relaxation time smaller than 0.76 ps and larger than 0.20 ps. A comparison between different ranges of FT-Raman and SERS band parameters of DNA extracted from leaf tissues, respectively, is given. We have found that the bands of DNA from Romus 3 and Rebra cultivars are suitable for studying the dynamical behaviour of molecular subgroups, in genomic nucleic acids extracted fromin vitro-grown apple plants.

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