A novel urine analysis technique combining affinity chromatography with Au nanoparticle based surface enhanced Raman spectroscopy for potential applications in non‐invasive cancer screening

2018 ◽  
Vol 12 (4) ◽  
pp. e201800327 ◽  
Author(s):  
Xueliang Lin ◽  
Lingna Wang ◽  
Huijing Lin ◽  
Duo Lin ◽  
Jinyong Lin ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Cancer Screening ◽  
Urine Analysis ◽  
Surface Enhanced Raman Spectroscopy ◽  
Au Nanoparticle ◽  
Non Invasive ◽  
Analysis Technique ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Potential Applications

scholarly journals In SituDetection of Trace Furfural in Aqueous Solution Based on Au Nanoparticle/Au Film Surface-Enhanced Raman Spectroscopy

2016 ◽  
Vol 2016 ◽  
pp. 1-8
Author(s):  
Wei Qi ◽  
Weigen Chen ◽  
Fu Wan ◽  
Jingxin Zou ◽  
Zhaoliang Gu
Keyword(s):  
Raman Spectroscopy ◽  
Electric Field ◽  
Surface Enhanced Raman Spectroscopy ◽  
Interparticle Spacing ◽  
Au Nanoparticle ◽  
Fdtd Simulation ◽  
Au Film ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Simulation Results

Furfural is an important chemical solvent and intermediate. Sensitive detection of this compound has attracted great interest in various fields. Surface-enhanced Raman spectroscopy (SERS) is a highly sensitive method for material detection because of its optical enhancement effect of plasmonic nanostructures. This study presents a simple and versatile method to synthesize a SERS substrate, where polyaminothiophenol (PATP) was used to realize the stable combination of Au nanoparticles (AuNPs) and Au film via self-assembly. The near-field electric field distribution was calculated using the finite difference time domain (FDTD) simulation to determine the parameters responsible for electric field enhancement. The simulation results show that SERS enhanced factors are sensitive to interparticle spacing and materials for solid support but insensitive to particle size. Moreover, the experimental results show that the optimized substrates with the highest Raman activity were formed by six layers of 60 nm AuNPs decorated on a 30 nm thick Au film, thereby validating the simulation results. The SERS factor of the optimal substrates is approximately 5.57 × 103, and thein situdetection limit is 4.8 ppm. The 3D Raman spectra, relative standard deviation values for major peaks, and changes in signal intensity with time show the good reproducibility and stability of the substrates.

Non-invasive diagnosis of Crohn's disease based on SERS combined with PCA-SVM

2021 ◽  
Author(s):  
Bingyan Li ◽  
Yaling Wu ◽  
Zijie Wang ◽  
Mengmeng Xing ◽  
Weimin Xu ◽  
...  
Keyword(s):  
Raman Spectroscopy ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Surface Enhanced Raman Spectroscopy ◽  
Metabolic Change ◽  
Healthy Controls ◽  
Non Invasive ◽  
Surface Enhanced ◽  
Surface Enhanced Raman

The metabolic change of patients (Crohn's disease (CD)/active CD (aCD)/inactive CD (iCD)) and healthy controls (HC) could be identified by measuring urine with surface-enhanced Raman spectroscopy (SERS).

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