Injectable pH and redox dual responsive hydrogels based on self-assembled peptides for anti-tumor drug delivery

2020 ◽  
Vol 8 (19) ◽  
pp. 5415-5426
Author(s):  
Ying Zhu ◽  
Liying Wang ◽  
Yiping Li ◽  
Zhewei Huang ◽  
Shiyao Luo ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Antitumor Drugs ◽  
Dual Responsive ◽  
Tumor Drug Delivery ◽  
Self Assembled ◽  
Peptide Hydrogels ◽  
Responsive Hydrogels

Dual responsive and injectable peptide hydrogels that form gels in vitro control the release of antitumor drugs in vivo.

Self-assembled drug delivery systems. Part 6: In vitro/in vivo studies of anticancer N-octadecanoyl gemcitabine nanoassemblies

2012 ◽  
Vol 430 (1-2) ◽  
pp. 276-281 ◽  
Author(s):  
Yiguang Jin ◽  
Yanju Lian ◽  
Lina Du ◽  
Shuangmiao Wang ◽  
Chang Su ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
In Vivo Studies ◽  
Self Assembled

Anti-tumor drug delivery system based on cyclodextrin-containing pH-responsive star polymer: In vitro and in vivo evaluation

2014 ◽  
Vol 474 (1-2) ◽  
pp. 232-240 ◽  
Author(s):  
Qingqing Xiong ◽  
Mingming Zhang ◽  
Zhibao Zhang ◽  
Wei Shen ◽  
Lingrong Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Star Polymer ◽  
Ph Responsive ◽  
In Vivo Evaluation ◽  
Tumor Drug Delivery

Biodegradable self-assembled PEG-PCL-PEG micelles for hydrophobic drug delivery, part 2: in vitro and in vivo toxicity evaluation

2010 ◽  
Vol 13 (2) ◽  
pp. 721-731 ◽  
Author(s):  
ChangYang Gong ◽  
YuJun Wang ◽  
XiuHong Wang ◽  
XiaWei Wei ◽  
QinJie Wu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Hydrophobic Drug ◽  
Toxicity Evaluation ◽  
In Vivo Toxicity ◽  
Self Assembled

The facile synthesis of hollow Au nanoflowers for synergistic chemo-photothermal cancer therapy

2015 ◽  
Vol 51 (76) ◽  
pp. 14338-14341 ◽  
Author(s):  
Shengnan Li ◽  
Lingyu Zhang ◽  
Tingting Wang ◽  
Lu Li ◽  
Chungang Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Drug Loading ◽  
Loading Capacity ◽  
Synthetic Route ◽  
Facile Synthesis ◽  
Delivery Performance ◽  
Dual Responsive

A novel, mild and facile synthetic route was first developed to fabricate hollow Au nanoflowers (designated as H-AuNFs) with drug loading capacity, superior photothermal conversion property and pH/NIR dual-responsive drug delivery performance for chemo-photothermal synergistic cancer therapy in vitro and in vivo.

Recent In Vitro and In Silico Advances in the Understanding of Intranasal Drug Delivery

2020 ◽  
Vol 26 ◽  
Author(s):  
John Chen ◽  
Andrew Martin ◽  
Warren H. Finlay
Keyword(s):  
Drug Delivery ◽  
In Silico ◽  
Local Drug Delivery ◽  
In Vivo Studies ◽  
Intranasal Drug Delivery ◽  
Nasal Sprays ◽  
In Silico Studies ◽  
Drug Delivery Devices

Background: Many drugs are delivered intranasally for local or systemic effect, typically in the form of droplets or aerosols. Because of the high cost of in vivo studies, drug developers and researchers often turn to in vitro or in silico testing when first evaluating the behavior and properties of intranasal drug delivery devices and formulations. Recent advances in manufacturing and computer technologies have allowed for increasingly realistic and sophisticated in vitro and in silico reconstructions of the human nasal airways. Objective: To perform a summary of advances in understanding of intranasal drug delivery based on recent in vitro and in silico studies. Conclusion: The turbinates are a common target for local drug delivery applications, and while nasal sprays are able to reach this region, there is currently no broad consensus across the in vitro and in silico literature concerning optimal parameters for device design, formulation properties and patient technique which would maximize turbinate deposition. Nebulizers are able to more easily target the turbinates, but come with the disadvantage of significant lung deposition. Targeting of the olfactory region of the nasal cavity has been explored for potential treatment of central nervous system conditions. Conventional intranasal devices, such as nasal sprays and nebulizers, deliver very little dose to the olfactory region. Recent progress in our understanding of intranasal delivery will be useful in the development of the next generation of intranasal drug delivery devices.

In vitro Lipolysis as a Tool for the Establishment of IVIVC for Lipid-Based Drug Delivery Systems

2019 ◽  
Vol 16 (8) ◽  
pp. 688-697
Author(s):  
Ravinder Verma ◽  
Deepak Kaushik
Keyword(s):  
Drug Delivery ◽  
Ph Value ◽  
Electron Paramagnetic Resonance Spectroscopy ◽  
Rapid Screening ◽  
Resonance Spectroscopy ◽  
Fed State ◽  
In Vitro Lipolysis ◽  
Ph Stat

: In vitro lipolysis has emerged as a powerful tool in the development of in vitro in vivo correlation for Lipid-based Drug Delivery System (LbDDS). In vitro lipolysis possesses the ability to mimic the assimilation of LbDDS in the human biological system. The digestion medium for in vitro lipolysis commonly contains an aqueous buffer media, bile salts, phospholipids and sodium chloride. The concentrations of these compounds are defined by the physiological conditions prevailing in the fasted or fed state. The pH of the medium is monitored by a pH-sensitive electrode connected to a computercontrolled pH-stat device capable of maintaining a predefined pH value via titration with sodium hydroxide. Copenhagen, Monash and Jerusalem are used as different models for in vitro lipolysis studies. The most common approach used in evaluating the kinetics of lipolysis of emulsion-based encapsulation systems is the pH-stat titration technique. This is widely used in both the nutritional and the pharmacological research fields as a rapid screening tool. Analytical tools for the assessment of in vitro lipolysis include HPLC, GC, HPTLC, SEM, Cryo TEM, Electron paramagnetic resonance spectroscopy, Raman spectroscopy and Nanoparticle Tracking Analysis (NTA) for the characterization of the lipids and colloidal phases after digestion of lipids. Various researches have been carried out for the establishment of IVIVC by using in vitro lipolysis models. The current publication also presents an updated review of various researches in the field of in vitro lipolysis.

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