Surface modification of poly(dimethylsiloxane) with a covalent antithrombin–heparin complex for the prevention of thrombosis: use of polydopamine as bonding agent

2015 ◽  
Vol 3 (29) ◽  
pp. 6032-6036 ◽  
Author(s):  
Jennifer M. Leung ◽  
Leslie R. Berry ◽  
Helen M. Atkinson ◽  
Rena M. Cornelius ◽  
Darren Sandejas ◽  
...  
Keyword(s):  
Surface Modification ◽  
Bonding Agent ◽  
Pdms Surface ◽  
Prevention Of Thrombosis ◽  
Blood Oxygenator

PDMS surface for blood oxygenator modified with antithrombin–heparin complexviapolydopamine.

PDMS Surface Modification Using Biomachining Method for Biomedical Application

2016 ◽  
Vol 26 ◽  
pp. 66-72 ◽  
Author(s):  
Yudan Whulanza ◽  
Hanif Nadhif ◽  
Jos Istiyanto ◽  
Sugeng Supriadi ◽  
Boy Bachtiar
Keyword(s):  
Surface Roughness ◽  
Surface Modification ◽  
Cell Attachment ◽  
Biomedical Application ◽  
Hydrophobic Surface ◽  
Polydimethyl Siloxane ◽  
Lab On Chip ◽  
Pdms Surface ◽  
A Cell ◽  
On Chip

Engineering a cell-friendly material in a form of lab-on-chip is the main goal of this study. The chip was made of polydimethyl siloxane (PDMS) with a surface modification to realize a groovy structure on its surface. This groovy surface was naturally and randomly designed via biomachining process. This measure was aimed to improve the cell attachment on the PDMS surface that always known as hydrophobic surface. The biomachined surface of mold and also products were characterized as surface roughness and wettability. The result shows that the biomachining process were able to be characterized in three classes of roughness on the surface of PDMS.

Recent developments in PDMS surface modification for microfluidic devices

2010 ◽  
Vol 31 (1) ◽  
pp. 2-16 ◽  
Author(s):  
Jinwen Zhou ◽  
Amanda Vera Ellis ◽  
Nicolas Hans Voelcker
Keyword(s):  
Surface Modification ◽  
Microfluidic Devices ◽  
Pdms Surface ◽  
Recent Developments

scholarly journals Sulfobetaine Polymers toward Application of Polydimethylsiloxane (PDMS) Surface Modification

2019 ◽  
Vol 31 (1) ◽  
pp. 33
Author(s):  
Mutsuo Tanaka ◽  
Yoshikatsu Ogawa ◽  
Yoshiki Hirata ◽  
Takahiro Sawaguchi ◽  
Shigeru Kurosawa
Keyword(s):  
Surface Modification ◽  
Pdms Surface

Research on the PDMS Surface Modification Technique

2013 ◽  
Vol 562-565 ◽  
pp. 131-135
Author(s):  
Li Tian ◽  
Lei Wu ◽  
Wei Wang ◽  
Xiao Wei Liu
Keyword(s):  
Contact Angle ◽  
Surface Modification ◽  
Polymer Materials ◽  
Oxygen Plasma Treatment ◽  
Pdms Surface ◽  
Coating Technique ◽  
Long Time ◽  
Aging Property ◽  
Modification Technique ◽  
Hydrophilic Character

UV radiation, oxygen plasma treatment and dynamical coating technique were the three main modification techniques to be widely applied in the surface modification of polymer materials. This paper presented the experiment results of PDMS surface modification with these three techniques. The contact angle was measured to test the modification effect, also the further verification testing of aging property after a long time storage were carried out. Of all the testing results, the dynamical coating technique, 10 layers 0.02% PDDA and PSS (V/V) alternatively adhesion on the PDMS surface, made the contact angle lowed to the 21°, and even after 15 days, it still kept as the 61°and exhibited the better hydrophilic character.

scholarly journals Surface Coating with Hyaluronic Acid-Gelatin-Crosslinked Hydrogel on Gelatin-Conjugated Poly(dimethylsiloxane) for Implantable Medical Device-Induced Fibrosis

Pharmaceutics ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 269
Author(s):  
Haejin Joo ◽  
Jonghyun Park ◽  
Chanutchamon Sutthiwanjampa ◽  
Hankoo Kim ◽  
Taehui Bae ◽  
...  
Keyword(s):  
Surface Modification ◽  
Hyaluronic Acid ◽  
Photoelectron Spectroscopy ◽  
Surface Hydrophobicity ◽  
Attenuated Total Reflection ◽  
Successful Implementation ◽  
Implantable Medical Device ◽  
Water Contact ◽  
Pdms Surface

Polydimethylsiloxane (PDMS) is a biocompatible polymer that has been applied in many fields. However, the surface hydrophobicity of PDMS can limit successful implementation, and this must be reduced by surface modification to improve biocompatibility. In this study, we modified the PDMS surface with a hydrogel and investigated the effect of this on hydrophilicity, bacterial adhesion, cell viability, immune response, and biocompatibility of PDMS. Hydrogels were created from hyaluronic acid and gelatin using a Schiff-base reaction. The PDMS surface and hydrogel were characterized using nuclear magnetic resonance, X-ray photoelectron spectroscopy, attenuated total reflection Fourier-transform infrared spectroscopy, and scanning electron microscopy. The hydrophilicity of the surface was confirmed via a decrease in the water contact angle. Bacterial anti-adhesion was demonstrated for Pseudomonas aeruginosa, Ralstonia pickettii, and Staphylococcus epidermidis, and viability and improved distribution of human-derived adipose stem cells were also confirmed. Decreased capsular tissue responses were observed in vivo with looser collagen distribution and reduced cytokine expression on the hydrogel-coated surface. Hydrogel coating on treated PDMS is a promising method to improve the surface hydrophilicity and biocompatibility for surface modification of biomedical applications.

scholarly journals Surface modification of Polydimethylsiloxane by hydrogels for microfluidic applications

2019 ◽  
Vol 5 (1) ◽  
pp. 93-96 ◽  
Author(s):  
Ralf Kemkemer ◽  
Zhang Zenghao ◽  
Yang Linxiao ◽  
Kiriaki Athanasopulu ◽  
Kerstin Frey ◽  
...  
Keyword(s):  
Surface Modification ◽  
Cell Growth ◽  
Essential Role ◽  
Hydrophobic Surface ◽  
Pdms Surface ◽  
In Vitro Investigation ◽  
On Chip ◽  
Organic Solutions ◽  
Tissue Matrix

AbstractIn vitro, hydrogel-based ECMs for functionalizing surfaces of various material have played an essential role in mimicking native tissue matrix. Polydimethylsiloxane (PDMS) is widely used to build microfluidic or organ-on-chip devices compatible with cells due to its easy handling in cast replication. Despite such advantages, the limitation of PDMS is its hydrophobic surface property. To improve wettability of PDMS-based devices, alginate, a naturally derived polysaccharide, was covalently bound to the PDMS surface. This alginate then crosslinked further hydrogel onto the PDMS surface in desired layer thickness. Hydrogel-modified PDMS was used for coating a topography chip system and in vitro investigation of cell growth on the surfaces. Moreover, such hydrophilic hydrogel-coated PDMS is utilized in a microfluidic device to prevent unspecific absorption of organic solutions. Hence, in both exemplary studies, PDMS surface properties were modified leading to improved devices.

An oxidized liquid metal-based microfluidic platform for tunable electronic device applications

Lab on a Chip ◽  
2015 ◽  
Vol 15 (3) ◽  
pp. 766-775 ◽  
Author(s):  
Guangyong Li ◽  
Mitesh Parmar ◽  
Dong-Weon Lee
Keyword(s):  
Surface Modification ◽  
Liquid Metal ◽  
Electronic Device ◽  
Microfluidic Platform ◽  
Pdms Surface ◽  
Device Applications ◽  
Surface Modification Techniques ◽  
Physical And Chemical

Two PDMS surface modification techniques (physical and chemical) are performed to enhance the non-wetting characteristics of Galinstan for electronic applications.

Parylene-PDMS Bilayer Coatings for Microelectronic and MEMS Packaging

2006 ◽  
Vol 968 ◽  
Author(s):  
Hyungsuk Lee ◽  
Junghyun Cho
Keyword(s):  
Surface Modification ◽  
Microelectromechanical Systems ◽  
Optical Microscope ◽  
Packaging Materials ◽  
Parylene C ◽  
Pdms Surface ◽  
Extensive Surface ◽  
And Performance ◽  
Mechanical Performances ◽  
Bilayer Coatings

ABSTRACTCurrent microelectronic devices and microelectromechanical systems (MEMS) require that packaging costs be reduced with more enhanced device performance. In addition, the packaging materials are often exposed to harsh environments, for which their performance is drastically degraded. Importantly, such devices become lighter and smaller, precluding the use of conventional packaging materials and schemes. Given that, surface coatings can provide an alternative solution for some of the aforementioned issues. Polydimethylsiloxane (PDMS) is a good candidate material in many encapsulating applications but its surface must be effectively protected due to its poor surface properties. In this study, the PDMS surface is coated with the parylene C film through a vapor-phase deposition. Proper surface modification of PDMS is then essential to generate desirable interfacial adhesion and performance between the parylene C and the PDMS. Effects of plasma treatment were examined in this study to evaluate their effectiveness on the surface modification of the PDMS. In order to explore mechanical performances of the bilayer coatings, dynamic nanoindentation and feedback-control nanoindentation testings were employed. In addition, extensive surface characterizations are performed with atomic force microscope (AFM) and optical microscope (OM).

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