scholarly journals On scattered waves and lipid domains: detecting membrane rafts with X-rays and neutrons

Soft Matter ◽  
2015 ◽  
Vol 11 (47) ◽  
pp. 9055-9072 ◽  
Author(s):  
Drew Marquardt ◽  
Frederick A. Heberle ◽  
Jonathan D. Nickels ◽  
Georg Pabst ◽  
John Katsaras
Keyword(s):  
Cell Membranes ◽  
Model Membrane ◽  
Biological Role ◽  
Membrane Rafts ◽  
Lipid Domains ◽  
X Rays ◽  
Membrane Systems ◽  
Mesoscopic Structure

In order to understand the biological role of lipids in cell membranes, it is necessary to determine the mesoscopic structure of well-defined model membrane systems.

scholarly journals Sphingolipid organization in biomembranes: what physical studies of model membranes reveal

1998 ◽  
Vol 111 (1) ◽  
pp. 1-9 ◽  
Author(s):  
R.E. Brown
Keyword(s):  
Signal Transduction ◽  
Model Membrane ◽  
Model Membranes ◽  
Lipid Domains ◽  
Membrane Systems ◽  
Biological Studies ◽  
Physical Interactions

Recent cell biological studies suggest that sphingolipids and cholesterol may cluster in biomembranes to form raft-like microdomains. Such lipid domains are postulated to function as platforms involved in the lateral sorting of certain proteins during their trafficking within cells as well as during signal transduction events. Here, the physical interactions that occur between cholesterol and sphingolipids in model membrane systems are discussed within the context of microdomain formation. A model is presented in which the role of cholesterol is refined compared to earlier models.

scholarly journals Bioinspired membrane-based systems for a physical approach of cell organization and dynamics: usefulness and limitations

2015 ◽  
Vol 5 (4) ◽  
pp. 20150038 ◽  
Author(s):  
Thibaut J. Lagny ◽  
Patricia Bassereau
Keyword(s):  
Cell Membranes ◽  
Cell Communication ◽  
Basic Research ◽  
Model Membrane ◽  
Membrane Systems ◽  
Vital Functions ◽  
Cell Components ◽  
Potential Applications ◽  
Long Time

Being at the periphery of each cell compartment and enclosing the entire cell while interacting with a large part of cell components, cell membranes participate in most of the cell's vital functions. Biologists have worked for a long time on deciphering how membranes are organized, how they contribute to trafficking, motility, cytokinesis, cell–cell communication, information transport, etc., using top-down approaches and always more advanced techniques. In contrast, physicists have developed bottom-up approaches and minimal model membrane systems of growing complexity in order to build up general models that explain how cell membranes work and how they interact with proteins, e.g. the cytoskeleton. We review the different model membrane systems that are currently available, and how they can help deciphering cell functioning, but also list their limitations. Model membrane systems are also used in synthetic biology and can have potential applications beyond basic research. We discuss the possible synergy between the development of complex in vitro membrane systems in a biological context and for technological applications. Questions that could also be discussed are: what can we still do with synthetic systems, where do we stop building up and which are the alternative solutions?

scholarly journals Correction: Effect of dibucaine hydrochloride on raft-like lipid domains in model membrane systems

MedChemComm ◽  
2016 ◽  
Vol 7 (4) ◽  
pp. 733-733
Author(s):  
Kazunari Yoshida ◽  
Akito Takashima ◽  
Izumi Nishio
Keyword(s):  
Model Membrane ◽  
Lipid Domains ◽  
Membrane Systems ◽  
Correction Effect

scholarly journals Effect of dibucaine hydrochloride on raft-like lipid domains in model membrane systems

MedChemComm ◽  
2015 ◽  
Vol 6 (8) ◽  
pp. 1444-1451 ◽  
Author(s):  
Kazunari Yoshida ◽  
Akito Takashima ◽  
Izumi Nishio
Keyword(s):  
Local Anaesthetic ◽  
Model Membrane ◽  
Lipid Domains ◽  
Membrane Systems ◽  
Physicochemical Mechanism

To clarify the biophysical and/or physicochemical mechanism of anaesthesia, we investigated the influence of dibucaine hydrochloride (DC·HCl), a local anaesthetic, on raft-like domains in ternary liposomes composed of dioleoylphosphatidylcholine (DOPC), dipalmitoylphosphatidylcholine (DPPC) and cholesterol (Chol).

Sign in / Sign up

Export Citation Format

Share Document