scholarly journals H2S gasotransmitter-responsive polymer vesicles

2016 ◽  
Vol 7 (3) ◽  
pp. 2100-2105 ◽  
Author(s):  
Qiang Yan ◽  
Wei Sang
Keyword(s):  
Drug Delivery ◽  
Hydrogen Sulfide ◽  
Cell Signaling ◽  
Diblock Copolymer ◽  
Targeted Drug Delivery ◽  
Self Assembly ◽  
Signaling Molecule ◽  
Polymer Vesicles ◽  
Responsive Polymer ◽  
Targeted Drug

A type of new polymeric vesicle self-assembly byo-azidomethylbenzoate-containing diblock copolymer can respond to the cell signaling molecule hydrogen sulfide (H2S). The intracellular H2S gasotransmitter can trigger biomimetic polymersome disruption for targeted drug delivery.

Facile, Template-Free Synthesis of Stimuli-Responsive Polymer Nanocapsules for Targeted Drug Delivery

2010 ◽  
Vol 122 (26) ◽  
pp. 4507-4510 ◽  
Author(s):  
Eunju Kim ◽  
Dongwoo Kim ◽  
Hyuntae Jung ◽  
Jiyeong Lee ◽  
Somak Paul ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Stimuli Responsive ◽  
Responsive Polymer ◽  
Template Free ◽  
Targeted Drug ◽  
Stimuli Responsive Polymer

Facile, Template-Free Synthesis of Stimuli-Responsive Polymer Nanocapsules for Targeted Drug Delivery

2010 ◽  
Vol 49 (26) ◽  
pp. 4405-4408 ◽  
Author(s):  
Eunju Kim ◽  
Dongwoo Kim ◽  
Hyuntae Jung ◽  
Jiyeong Lee ◽  
Somak Paul ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Stimuli Responsive ◽  
Responsive Polymer ◽  
Template Free ◽  
Targeted Drug ◽  
Stimuli Responsive Polymer

Anti-Glioma Effect with Targeting Therapy Using Folate Modified Nano-Micelles Delivery Curcumin

2020 ◽  
Vol 16 (1) ◽  
pp. 1-13 ◽  
Author(s):  
Yihong He ◽  
Cong Wu ◽  
Jiayu Duan ◽  
Junming Miao ◽  
Hongyu Ren ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Self Assembly ◽  
Targeting Therapy ◽  
Tumor Bearing ◽  
Clinical Benefits ◽  
Targeted Drug ◽  
Novel Drug ◽  
Targeted Drug Delivery Systems

Targeted drug delivery systems have currently demonstrated considerable potential clinical benefits in cancer treatment. Curcumin has become a candidate anti-tumor drug for the therapy of glioblastoma multiforme (GBM) by increasing cell apoptosis and suppressing cell proliferation. In current research, we explored a novel targeted drug delivery system with a self-assembly measure by curcumin, MPEG-PLA and Fa-PEG-PLA. Compared with free curcumin and Cur/MPEG-PLA, Cur/Fa-PEG-PLA can remarkably suppress the growth of GL261 cells and promote apoptotic rate. Moreover, after the procession of tumor-bearing mice with curcumin/Fa-PEG-PLA complex, tumor growth in subcutaneous and intracranial tumor models were repressed via suppressing angiogenesis and facilitating apoptosis in vivo. The Curcumin/Fa-PEG-PLA nanoparticle may be a novel drug for the therapy of GBM.

Hydrogen Sulfide Triggered Charge-Reversal Micelles for Cancer-Targeted Drug Delivery and Imaging

2016 ◽  
Vol 8 (25) ◽  
pp. 16227-16239 ◽  
Author(s):  
Haitao Zhang ◽  
Xiuqi Kong ◽  
Yonghe Tang ◽  
Weiying Lin
Keyword(s):  
Drug Delivery ◽  
Hydrogen Sulfide ◽  
Targeted Drug Delivery ◽  
Charge Reversal ◽  
Targeted Drug
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