Hydrogen Sulfide Triggered Charge-Reversal Micelles for Cancer-Targeted Drug Delivery and Imaging

2016 ◽  
Vol 8 (25) ◽  
pp. 16227-16239 ◽  
Author(s):  
Haitao Zhang ◽  
Xiuqi Kong ◽  
Yonghe Tang ◽  
Weiying Lin
Keyword(s):  
Drug Delivery ◽  
Hydrogen Sulfide ◽  
Targeted Drug Delivery ◽  
Charge Reversal ◽  
Targeted Drug

Linear polyethyleneimine-based charge-reversal nanoparticles for nuclear-targeted drug delivery

2011 ◽  
Vol 21 (47) ◽  
pp. 19114 ◽  
Author(s):  
Zhuxian Zhou ◽  
Youqing Shen ◽  
Jianbin Tang ◽  
Erlei Jin ◽  
Xinpeng Ma ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Charge Reversal ◽  
Targeted Drug

scholarly journals H2S gasotransmitter-responsive polymer vesicles

2016 ◽  
Vol 7 (3) ◽  
pp. 2100-2105 ◽  
Author(s):  
Qiang Yan ◽  
Wei Sang
Keyword(s):  
Drug Delivery ◽  
Hydrogen Sulfide ◽  
Cell Signaling ◽  
Diblock Copolymer ◽  
Targeted Drug Delivery ◽  
Self Assembly ◽  
Signaling Molecule ◽  
Polymer Vesicles ◽  
Responsive Polymer ◽  
Targeted Drug

A type of new polymeric vesicle self-assembly byo-azidomethylbenzoate-containing diblock copolymer can respond to the cell signaling molecule hydrogen sulfide (H2S). The intracellular H2S gasotransmitter can trigger biomimetic polymersome disruption for targeted drug delivery.

scholarly journals Charge-reversal nanoparticles: novel targeted drug delivery carriers

2016 ◽  
Vol 6 (4) ◽  
pp. 261-267 ◽  
Author(s):  
Xinli Chen ◽  
Lisha Liu ◽  
Chen Jiang
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Charge Reversal ◽  
Targeted Drug

scholarly journals Dual-pH Sensitive Charge-reversal Nanocomplex for Tumor-targeted Drug Delivery with Enhanced Anticancer Activity

Theranostics ◽  
2017 ◽  
Vol 7 (7) ◽  
pp. 1806-1819 ◽  
Author(s):  
Qing Zhou ◽  
Yilin Hou ◽  
Li Zhang ◽  
Jianlin Wang ◽  
Youbei Qiao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Activity ◽  
Targeted Drug Delivery ◽  
Ph Sensitive ◽  
Charge Reversal ◽  
Targeted Drug

scholarly journals Integrated prodrug micelles with two-photon bioimaging and pH-triggered drug delivery for cancer theranostics

2019 ◽  
Vol 7 (2) ◽  
pp. 171-180
Author(s):  
Hong Xu ◽  
Boxuan Ma ◽  
Jizhou Jiang ◽  
Sutong Xiao ◽  
Rongrong Peng ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Side Effect ◽  
Antitumor Efficacy ◽  
Tissue Imaging ◽  
Charge Reversal ◽  
Two Photon ◽  
Targeted Drug ◽  
Cancer Theranostics

Abstract Nanodrug carriers with fluorescence radiation are widely used in cancer diagnosis and therapy due to their real-time imaging, less side effect, better drug utilization as well as the good bioimaging ability. However, traditional nanocarriers still suffer from unexpectable drug leakage, unsatisfactory tumor-targeted drug delivery and shallow imaging depth, which limit their further application in cancer theranostics. In this study, an integrated nanoplatform is constructed by polymeric prodrug micelles with two-photon and aggregation-induced emission bioimaging, charge reversal and drug delivery triggered by acidic pH. The prodrug micelles can be self-assembled by the TP-PEI (DA/DOX)-PEG prodrug polymer, which consists of the two-photon fluorophore (TP), dimethylmaleic anhydride (DA) grafted polyethyleneimine (PEI) and polyethylene glycol (PEG). The PEG segment, DOX and DA are bridged to polymer by acid cleavable bonds, which provides the micelles a ‘stealth’ property and a satisfactory stability during blood circulation, while the outside PEG segment is abandoned along with the DA protection in the tumor acidic microenvironment, thus leading to charge reversal-mediated accelerated endocytosis and tumor-targeted drug delivery. The great antitumor efficacy and reduced side effect of these pH-sensitive prodrug micelles are confirmed by antitumor assays in vitro and in vivo. Meanwhile, these micelles exhibited great deep-tissue two-photon bioimaging ability up to 150 μm in depth. The great antitumor efficacy, reduced side effect and deep two-photon tissue imaging make the TP-PEI (DA/DOX)-PEG prodrug micelles would be an efficient strategy for theranostic nanoplatform in cancer treatment.

Synthesis and in vitro evaluation of charge reversal photoresponsive quinoline tethered mesoporous silica for targeted drug delivery

2014 ◽  
Vol 2 (45) ◽  
pp. 7971-7977 ◽  
Author(s):  
S. Karthik ◽  
Avijit Jana ◽  
Biswajit Saha ◽  
B. Krishna Kalyani ◽  
Sudip Kumar Ghosh ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Anticancer Drug ◽  
Targeted Drug Delivery ◽  
Targeted Delivery ◽  
Charge Reversal ◽  
In Vitro Evaluation ◽  
Targeted Drug

We developed excellent charge reversal photoresponsive nanoparticles for targeted delivery of the anticancer drug chlorambucil.

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