Hierarchical self-assembly of magnetic nanoclusters for theranostics: Tunable size, enhanced magnetic resonance imagability, and controlled and targeted drug delivery

2016 ◽  
Vol 35 ◽  
pp. 109-117 ◽  
Author(s):  
Dai Hai Nguyen ◽  
Jung Seok Lee ◽  
Jong Hoon Choi ◽  
Kyung Min Park ◽  
Yunki Lee ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Magnetic Resonance ◽  
Targeted Drug Delivery ◽  
Self Assembly ◽  
Magnetic Nanoclusters ◽  
Targeted Drug

Anti-Glioma Effect with Targeting Therapy Using Folate Modified Nano-Micelles Delivery Curcumin

2020 ◽  
Vol 16 (1) ◽  
pp. 1-13 ◽  
Author(s):  
Yihong He ◽  
Cong Wu ◽  
Jiayu Duan ◽  
Junming Miao ◽  
Hongyu Ren ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Targeted Drug Delivery ◽  
Self Assembly ◽  
Targeting Therapy ◽  
Tumor Bearing ◽  
Clinical Benefits ◽  
Targeted Drug ◽  
Novel Drug ◽  
Targeted Drug Delivery Systems

Targeted drug delivery systems have currently demonstrated considerable potential clinical benefits in cancer treatment. Curcumin has become a candidate anti-tumor drug for the therapy of glioblastoma multiforme (GBM) by increasing cell apoptosis and suppressing cell proliferation. In current research, we explored a novel targeted drug delivery system with a self-assembly measure by curcumin, MPEG-PLA and Fa-PEG-PLA. Compared with free curcumin and Cur/MPEG-PLA, Cur/Fa-PEG-PLA can remarkably suppress the growth of GL261 cells and promote apoptotic rate. Moreover, after the procession of tumor-bearing mice with curcumin/Fa-PEG-PLA complex, tumor growth in subcutaneous and intracranial tumor models were repressed via suppressing angiogenesis and facilitating apoptosis in vivo. The Curcumin/Fa-PEG-PLA nanoparticle may be a novel drug for the therapy of GBM.

scholarly journals H2S gasotransmitter-responsive polymer vesicles

2016 ◽  
Vol 7 (3) ◽  
pp. 2100-2105 ◽  
Author(s):  
Qiang Yan ◽  
Wei Sang
Keyword(s):  
Drug Delivery ◽  
Hydrogen Sulfide ◽  
Cell Signaling ◽  
Diblock Copolymer ◽  
Targeted Drug Delivery ◽  
Self Assembly ◽  
Signaling Molecule ◽  
Polymer Vesicles ◽  
Responsive Polymer ◽  
Targeted Drug

A type of new polymeric vesicle self-assembly byo-azidomethylbenzoate-containing diblock copolymer can respond to the cell signaling molecule hydrogen sulfide (H2S). The intracellular H2S gasotransmitter can trigger biomimetic polymersome disruption for targeted drug delivery.

scholarly journals Gd3+ Doped CoFe2O4 Nanoparticles for Targeted Drug Delivery and Magnetic Resonance Imaging

2021 ◽  
Vol 7 (4) ◽  
pp. 47
Author(s):  
Fatima Javed ◽  
Muhammad Asad Abbas ◽  
Muhammad Imran Asad ◽  
Naveed Ahmed ◽  
Nauman Naseer ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Drug Delivery ◽  
Magnetic Resonance ◽  
Targeted Drug Delivery ◽  
Sol Gel ◽  
Resonance Imaging ◽  
Sustained Drug Release ◽  
Auto Combustion ◽  
Eudragit E100 ◽  
Targeted Drug

Nanoparticles of CoGdxFe2 − xO4 (x = 0%, 25%, 50%) synthesized via sol–gel auto combustion technique and encapsulated within a polymer (Eudragit E100) shell containing curcumin by single emulsion solvent evaporation technique were formulated in this study. Testing of synthesized nanoparticles was carried out by using different characterization techniques, to investigate composition, crystallinity, size, morphology, surface charge, functional groups and magnetic properties of the samples. The increased hydrophilicity resulted in sustained drug release of 90.6% and 95% for E1(CoGd0.25Fe1.75O4) and E2(CoGd0.50Fe1.5O4), respectively, over a time span of 24 h. The relaxivities of the best-chosen samples were measured by using a 3T magnetic resonance imaging (MRI) machine, and a high r2/r1 ratio of 43.64 and 23.34 for composition E1(CoGd0.25Fe1.75O4) and E2(CoGd0.50Fe1.5O4) suggests their ability to work as a better T2 contrast agent. Thus, these novel synthesized nanostructures cannot only enable MRI diagnosis but also targeted drug delivery.

scholarly journals Fabrication of a hyaluronic acid conjugated metal organic framework for targeted drug delivery and magnetic resonance imaging

RSC Advances ◽  
2018 ◽  
Vol 8 (12) ◽  
pp. 6581-6589 ◽  
Author(s):  
Fangpeng Shu ◽  
Daojun Lv ◽  
Xian-Lu Song ◽  
Bin Huang ◽  
Chong Wang ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Drug Delivery ◽  
Hyaluronic Acid ◽  
Magnetic Resonance ◽  
Targeted Drug Delivery ◽  
Metal Organic Framework ◽  
Resonance Imaging ◽  
One Pot ◽  
Metal Organic ◽  
Targeted Drug

DOX-doped MOF nanoparticles were prepared via a one-pot reaction and successively anchored with Fe3+ and HA for simultaneous targeted drug delivery and MR imaging.

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