Combinatorial synthesis of spiro[indoline-3,2′-pyrrole] derivatives via a three-component reaction under catalyst-free conditions

RSC Advances ◽  
2016 ◽  
Vol 6 (13) ◽  
pp. 10412-10418 ◽  
Author(s):  
Guanghao Shi ◽  
Xinwei He ◽  
Yongjia Shang ◽  
Meihua Xie
Keyword(s):  
Amino Acid ◽  
Combinatorial Synthesis ◽  
Pyrrole Derivatives ◽  
Catalyst Free ◽  
Three Component Reaction ◽  
Acid Esters

Reported here is a convenient catalyst-free method for preparing a series of spiro[indoline-3,2′-pyrroles] from a three-component reaction of isatins, α-amino acid and phenylpropiolic acid esters in refluxing isopropanol with high regioselectivity and yields.

Group-Assisted-Purification Chemistry Strategy for the Efficient Assembly of Cyclic Fused Pyridinones

Synthesis ◽  
2021 ◽  
Author(s):  
Di Ke ◽  
You Wu ◽  
Lei Zhang ◽  
Jiaan Shao ◽  
Yongping Yu ◽  
...  
Keyword(s):  
Amino Acid ◽  
Amino Alcohols ◽  
Aliphatic Amines ◽  
Amino Acid Esters ◽  
Reaction Condition ◽  
Excellent Yield ◽  
Three Component Reaction ◽  
Work Up ◽  
Acid Esters

A group-assisted-purification (GAP) chemistry strategy based Ugi four-center three-component reaction (Ugi-4C-3CR) was explored. The reaction proceeded well to deliver the cyclic fused pyridinones selectively. Moreover, the reaction condition was mild and avoided additional chromatography or recrystallization work-up. Also, wide variations in substrates, such as anilines and aliphatic amines as well as amino alcohols and amino acid esters were all tolerated and achieved in good to excellent yields. Importantly, ladder-type cyclic fused pyridinones can be further constructed with excellent yield of 91%.

Novel One-pot Synthesis of Pyranocarbazole Derivatives via an Isocyanide-based Three-component Reaction

2020 ◽  
Vol 17 ◽  
Author(s):  
Visarapu Malathi ◽  
Pedavenkatagari Narayana Reddy ◽  
Pannala Padmaja
Keyword(s):  
Efficient Method ◽  
Atom Economy ◽  
Reaction Conditions ◽  
One Pot ◽  
Catalyst Free ◽  
One Pot Synthesis ◽  
Three Component Reaction ◽  
High Yields

Abstract:: An efficient method has been developed for the synthesis of new pyrano[3,2-c] and pyrano[3,2-a]carbazole de-rivatives via a three component reaction of 4-hydroxycarbazole or 2-hydroxycarbazole, isocyanides, and dialkylacetylenedi-carboxylates. Noteworthy features of this protocol include mild reaction conditions, catalyst-free, high atom-economy and high yields.

Asymmetric Preparation of anti-β-Hydroxyα-amino Acid Esters

Synfacts ◽  
2006 ◽  
Vol 2006 (12) ◽  
pp. 1253-1253
Author(s):  
Y. Hamada ◽  
K. Makino ◽  
M. Iwasaki
Keyword(s):  
Amino Acid ◽  
Amino Acid Esters ◽  
Acid Esters

Antiviral activity of glycyrrhizic acid conjugates with amino acid esters against Zika virus

2021 ◽  
Vol 294 ◽  
pp. 198290
Author(s):  
Lidia A. Baltina ◽  
Mann-Jen Hour ◽  
Ya-Chi Liu ◽  
Young-Sheng Chang ◽  
Su-Hua Huang ◽  
...  
Keyword(s):  
Amino Acid ◽  
Antiviral Activity ◽  
Zika Virus ◽  
Glycyrrhizic Acid ◽  
Amino Acid Esters ◽  
Acid Esters
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