Combinatorial Synthesis of Pyrrolo[3,2-f]quinoline and Pyrrolo[3,2-a]acridine Derivatives via a Three-Component Reaction under Catalyst-Free Conditions

2013 ◽  
Vol 15 (9) ◽  
pp. 498-502 ◽  
Author(s):  
Yu-Jing Zhou ◽  
Dong-Sheng Chen ◽  
Yu-Ling Li ◽  
Yun Liu ◽  
Xiang-Shan Wang
Keyword(s):  
Combinatorial Synthesis ◽  
Acridine Derivatives ◽  
Catalyst Free ◽  
Three Component Reaction

Combinatorial synthesis of spiro[indoline-3,2′-pyrrole] derivatives via a three-component reaction under catalyst-free conditions

RSC Advances ◽  
2016 ◽  
Vol 6 (13) ◽  
pp. 10412-10418 ◽  
Author(s):  
Guanghao Shi ◽  
Xinwei He ◽  
Yongjia Shang ◽  
Meihua Xie
Keyword(s):  
Amino Acid ◽  
Combinatorial Synthesis ◽  
Pyrrole Derivatives ◽  
Catalyst Free ◽  
Three Component Reaction ◽  
Acid Esters

Reported here is a convenient catalyst-free method for preparing a series of spiro[indoline-3,2′-pyrroles] from a three-component reaction of isatins, α-amino acid and phenylpropiolic acid esters in refluxing isopropanol with high regioselectivity and yields.

Novel One-pot Synthesis of Pyranocarbazole Derivatives via an Isocyanide-based Three-component Reaction

2020 ◽  
Vol 17 ◽  
Author(s):  
Visarapu Malathi ◽  
Pedavenkatagari Narayana Reddy ◽  
Pannala Padmaja
Keyword(s):  
Efficient Method ◽  
Atom Economy ◽  
Reaction Conditions ◽  
One Pot ◽  
Catalyst Free ◽  
One Pot Synthesis ◽  
Three Component Reaction ◽  
High Yields

Abstract:: An efficient method has been developed for the synthesis of new pyrano[3,2-c] and pyrano[3,2-a]carbazole de-rivatives via a three component reaction of 4-hydroxycarbazole or 2-hydroxycarbazole, isocyanides, and dialkylacetylenedi-carboxylates. Noteworthy features of this protocol include mild reaction conditions, catalyst-free, high atom-economy and high yields.

Synthesis of isoxazolidines via catalyst-free one-pot three-component cycloaddition of sulfoxonium ylides, nitrosoarenes and alkenes

2021 ◽  
Author(s):  
Xing Li ◽  
Pingan Zhai ◽  
Yongsheng Fang ◽  
Wenhui Li ◽  
Honghong Chang ◽  
...  
Keyword(s):  
One Pot ◽  
Catalyst Free ◽  
Practical Strategy ◽  
Three Component Reaction

A general and practical strategy for the construction of various keto-substituted isoxazolidines via one-pot three-component reaction of easily accessible, safer and more stable sulfoxonium ylides, nitrosoarenes and olefins is described.

Isocyanide-based three component reaction for synthesis of highly cyano substituted furan derivatives

RSC Advances ◽  
2016 ◽  
Vol 6 (32) ◽  
pp. 26783-26790 ◽  
Author(s):  
Hamid Reza Safaei ◽  
Farbod Dehbozorgi
Keyword(s):  
Solvent Free ◽  
One Pot ◽  
Furan Derivatives ◽  
Catalyst Free ◽  
One Pot Synthesis ◽  
Three Component Reaction

A rapid and efficient solvent-free one-pot synthesis of novel alkyl amino aryl furan tricarbonitrile derivatives is described under catalyst-free conditions.

N-Methyl nitrones as substrates for access to N-aryl isoxazolidines via catalyst-free one-pot three-component reaction with nitrosoarenes and olefins

2021 ◽  
Author(s):  
Pingan Zhai ◽  
Wenhui Li ◽  
Jianying Lin ◽  
Shuangping Huang ◽  
Wenchao Gao ◽  
...  
Keyword(s):  
One Pot ◽  
Catalyst Free ◽  
Three Component Reaction

N-Methyl nitrones bearing wider scope are used as starting materials to construct various N-aryl isoxazolidines instead of N-methyl isoxazolidines or N−H 1,3-oxazinanes via catalyst-free one-pot three-component reaction with nitrosoarenes and...

scholarly journals A novel three-component reaction between isocyanides, alcohols or thiols and elemental sulfur: a mild, catalyst-free approach towards O-thiocarbamates and dithiocarbamates

2019 ◽  
Vol 15 ◽  
pp. 1523-1533 ◽  
Author(s):  
András György Németh ◽  
György Miklós Keserű ◽  
Péter Ábrányi-Balogh
Keyword(s):  
Elemental Sulfur ◽  
Building Blocks ◽  
Reaction Conditions ◽  
One Pot ◽  
Catalyst Free ◽  
Synthetic Procedure ◽  
Three Component Reaction ◽  
Wide Range ◽  
Organic Chemist ◽  
The One

A new multicomponent reaction has been developed between isocyanides, sulfur and alcohols or thiols under mild reaction conditions to afford O-thiocarbamates and dithiocarbamates in moderate to good yields. The one-pot reaction cascade involves the formation of an isothiocyanate intermediate, thus a catalyst-free synthesis of isothiocyanates, as valuable building blocks from isocyanides and sulfur is proposed, as well. The synthetic procedure suits the demand of a modern organic chemist, as it tolerates a wide range of functional groups, it is atom economic and easily scalable.

One-Pot Three-Component Synthesis of Bispyrazole-thiazole-pyran-2-one Heterocyclic Hybrids

Synlett ◽  
2018 ◽  
Vol 29 (13) ◽  
pp. 1776-1780 ◽  
Author(s):  
Yahia Rachedi ◽  
Oualid Talhi ◽  
Artur Silva ◽  
Aicha Saidoun ◽  
Leila Boukenna ◽  
...  
Keyword(s):  
Structural Diversity ◽  
2D Nmr ◽  
Spectroscopic Studies ◽  
One Pot ◽  
Catalyst Free ◽  
Three Component Reaction

A new series of some interesting bispyrazole-thiazole-pyran-2-one heterocyclic hybrids has been efficiently synthesized via a one-pot catalyst-free three-component reaction of α-bromoacetylated pyran-2-one derivatives, thiosemicarbazide, and polysubstituted-1-(1H-pyrazol-4-yl)butane-1,3-diones. This multicomponent procedure has been advantageously applied to prepare a structural diversity of hetero­cyclic hybrids characterized by extensive 1D and 2D NMR spectroscopic studies.

Sign in / Sign up

Export Citation Format

Share Document